Volume 33 Issue 2
Mar.  2012
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BIAN Hui, FANG Song, MIAO Ying-Da, YU Hua-Lin. Influences of two different training paradigms on spatial learning and memory performance of hippocampal injured rats. Zoological Research, 2012, (2): 237-240. doi: 10.3724/SP.J.1141.2012.02237
Citation: BIAN Hui, FANG Song, MIAO Ying-Da, YU Hua-Lin. Influences of two different training paradigms on spatial learning and memory performance of hippocampal injured rats. Zoological Research, 2012, (2): 237-240. doi: 10.3724/SP.J.1141.2012.02237

Influences of two different training paradigms on spatial learning and memory performance of hippocampal injured rats

doi: 10.3724/SP.J.1141.2012.02237
  • Received Date: 2011-08-09
  • Rev Recd Date: 2011-11-20
  • Publish Date: 2012-04-22
  • In this study, the 5 d and 7 d training paradigms were adopted to investigate the influences of different training procedures on the performance of spatial learning and memory of the hippocampal injured rats. The results showed that during the hidden-platform acquisition training, similar spatial learning dysfunctions were indicated in those two training paradigms. Whereas, when the spatial memories have been evaluated, compared with the 5 d training groups,the rats under 7 d training procedure not only crossed the platform location less, but also preferred to spend less time in the target quadrant.
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  • [1] Crabbe JC, Wahlsten D, Dudek BC. 1999. Genetics of mouse behavior: interactions with laboratory environment[J]. Science, 284(5420): 1670-1672.
    [2] D’Hooge R, De Deyn PP. 2001. Applications of the Morris water maze in the study of learning and memory[J]. Brain Res Rev, 36(1): 60-90.
    [3] Hodges H. 1996. Maze procedures: the radial-arm and water maze compared[J]. Cogn Brain Res, 3(3-4): 167-181.
    [4] Morris R. 1984. Developments of a water-maze procedure for studying spatial learning in the rat[J]. J Neurosci Meth, 11(1): 47-60.
    [5] Morris RGM. 1981. Spatial localization does not require the presence of local cues[J]. Learn Motiv, 12(2): 239-260.
    [6] Morris RGM, Garrud P, Rawlins JNP, O’Keefe J. 1982. Place navigation impaired in rats with hippocampal lesions[J]. Nature, 297(868): 681-683.
    [7] Moser E, Moser MB, Andersen P. 1993. Spatial learning impairment parallels the magnitude of dorsal hippocampal lesions, but is hardly present following ventral lesions[J]. J Neurosci, 13(9): 3916-3925.
    [8] Moser MB, Moser EI, Forrest E, Andersen P, Morris RG. 1995. Spatial learning with a minislab in the dorsal hippocampus[J]. Proc Natl Acad Sci USA, 92(21): 9697-9701.
    [9] Paxinos G, Watson C. 1998. The Rat Brain in Stereotaxic Coordinates[M]. 4th ed. San Diego: Academic Press.
    [10] Rapp PR, Gallagher M. 1996. Preserved neuron number in the hippocampus of aged rats with spatial learning deficits[J]. Proc Natl Acad Sci USA, 93(18): 9926-9930.
    [11] Riedel G, Micheau J, Lam AGM, Roloff EVL, Martin SJ, Bridge H, De Hoz L, Poeschel B, McCulloch J, Morris RGM. 1999. Reversible neural inactivation reveals hippocampal participation in several memory processes[J]. Nat Neurosci, 2(10): 898-905.
    [12] Vorhees CV, Williams MT. 2006. Morris water maze: procedures for assessing spatial and related forms of learning and memory[J]. Nat Protoc, 1(2): 848-858.
    [13] Wood ER, Mumby DG, Pinel JP, Phillips AG. 1993. Impaired object recognition memory in rats following ischemia-induced damage to the hippocampus[J]. Behav Neurosci, 107(1): 51-62.
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Influences of two different training paradigms on spatial learning and memory performance of hippocampal injured rats

doi: 10.3724/SP.J.1141.2012.02237

Abstract: In this study, the 5 d and 7 d training paradigms were adopted to investigate the influences of different training procedures on the performance of spatial learning and memory of the hippocampal injured rats. The results showed that during the hidden-platform acquisition training, similar spatial learning dysfunctions were indicated in those two training paradigms. Whereas, when the spatial memories have been evaluated, compared with the 5 d training groups,the rats under 7 d training procedure not only crossed the platform location less, but also preferred to spend less time in the target quadrant.

BIAN Hui, FANG Song, MIAO Ying-Da, YU Hua-Lin. Influences of two different training paradigms on spatial learning and memory performance of hippocampal injured rats. Zoological Research, 2012, (2): 237-240. doi: 10.3724/SP.J.1141.2012.02237
Citation: BIAN Hui, FANG Song, MIAO Ying-Da, YU Hua-Lin. Influences of two different training paradigms on spatial learning and memory performance of hippocampal injured rats. Zoological Research, 2012, (2): 237-240. doi: 10.3724/SP.J.1141.2012.02237
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