Volume 33 Issue 1
Jan.  2012
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WU Xu-Jun, ZONG Wei, SUN Yong-Mei, HU Xin-Tian, MA Yuan-Ye, WANG Jian-Hong. Morphine addiction in non-human primates using rhesus monkeys. Zoological Research, 2012, 33(1): 89-91. doi: 10.3724/SP.J.1141.2012.01089
Citation: WU Xu-Jun, ZONG Wei, SUN Yong-Mei, HU Xin-Tian, MA Yuan-Ye, WANG Jian-Hong. Morphine addiction in non-human primates using rhesus monkeys. Zoological Research, 2012, 33(1): 89-91. doi: 10.3724/SP.J.1141.2012.01089

Morphine addiction in non-human primates using rhesus monkeys

doi: 10.3724/SP.J.1141.2012.01089
  • Received Date: 2011-12-19
  • Rev Recd Date: 2012-01-05
  • Publish Date: 2012-02-22
  • We showed that rhesus monkeys (Macaca mulatta) can develop a morphine dependence. Rhesus monkeys successfully established a conditioned place preference (CPP) induced by morphine treatment and this preference lasted for at least (36.3±1.3) months. This animal model may be useful for research into addiction in humans.
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  • [1] Foltin RW, Evans SM. 2001. Location preference related to smoked heroin self-administration by rhesus monkeys
    [J]. Psychopharmacology:Berl, 155: 419-425.
    [3] Hnasko TS, Sotak BN, Palmiter RD. 2005. Morphine reward in dopamine-deficient mice
    [J]. Nature, 438: 854-857.
    [5] Marquez P, Bebawy D, Lelievre V, Coute AC, Evans CJ, Waschek JA, Lutfy K. 2009. The role of endogenous PACAP in motor stimulation and conditioned place preference induced by morphine in mice
    [6] [J].
    [7] Psychopharmacology: Berl, 204: 457-463.
    [8] Rice OV, Gordon N, Gifford AN. 2002. Conditioned place preference to morphine in cannabinoid CB1 receptor knockout mice
    [J]. Brain Res, 945: 135-138.
    [10] Tan H, Liu N, Wilson FA, Ma Y. 2007. Effects of scopolamine on morphine-induced conditioned place preference in mice
    [J]. Addict Biol, 12: 463-469.
    [12] Vindenes V, Handal M, Ripel A, Boix F, Morland J. 2006. Conditioned place preference induced by morphine and morphine-6-glucuronide in mice
    [J]. Pharmacol Biochem Behav, 85: 292-297.
    [14] Wang JH, Wu XJ, Li CY, Wei JK, Jiang HH, Liu CR, Yu CY, Carlson S, Hu XT, Duan W, Ma YY. 2011. Effect of morphine on conditioned place preference in rhesus monkeys
    [J]. Addict Biol, doi: 0.1111/j.1369-1600.2010.00289.x. (Online version).
    [16] Zhang J, Tan H, Niu HC, Wang JH, Tang XD, Sanford LD, Ma YY. 2008. Pentylenetetrazole-induced status epilepticus following training does not impair expression of morphine-induced conditioned place preference
    [J]. Addict Biol, 14: 174-184.
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Morphine addiction in non-human primates using rhesus monkeys

doi: 10.3724/SP.J.1141.2012.01089

Abstract: We showed that rhesus monkeys (Macaca mulatta) can develop a morphine dependence. Rhesus monkeys successfully established a conditioned place preference (CPP) induced by morphine treatment and this preference lasted for at least (36.3±1.3) months. This animal model may be useful for research into addiction in humans.

WU Xu-Jun, ZONG Wei, SUN Yong-Mei, HU Xin-Tian, MA Yuan-Ye, WANG Jian-Hong. Morphine addiction in non-human primates using rhesus monkeys. Zoological Research, 2012, 33(1): 89-91. doi: 10.3724/SP.J.1141.2012.01089
Citation: WU Xu-Jun, ZONG Wei, SUN Yong-Mei, HU Xin-Tian, MA Yuan-Ye, WANG Jian-Hong. Morphine addiction in non-human primates using rhesus monkeys. Zoological Research, 2012, 33(1): 89-91. doi: 10.3724/SP.J.1141.2012.01089
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