Volume 33 Issue 1
Jan.  2012
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TANG Xiang-Hui, CAO Yue-Ling, YANG Ze-Xing, ZHAO Fu-Xian. Reproductive traits of polycystic ovary syndrome in female rhesus monkeys. Zoological Research, 2012, 33(1): 37-42. doi: 10.3724/SP.J.1141.2012.01037
Citation: TANG Xiang-Hui, CAO Yue-Ling, YANG Ze-Xing, ZHAO Fu-Xian. Reproductive traits of polycystic ovary syndrome in female rhesus monkeys. Zoological Research, 2012, 33(1): 37-42. doi: 10.3724/SP.J.1141.2012.01037

Reproductive traits of polycystic ovary syndrome in female rhesus monkeys

doi: 10.3724/SP.J.1141.2012.01037
Funds:  This work was supported by Yunnan Key Laboratory of Animal Reproductive Biology(2010-03)
  • Received Date: 2011-10-24
  • Rev Recd Date: 2011-12-10
  • Publish Date: 2012-02-22
  • The objective of this study was to set up a rhesus monkey model of polycystic ovary syndrome (PCOS), which is globally prevalent among reproductive-aged human women, and to understand the reproductive traits of PCOS female monkeys. Six adult female rhesus monkeys aged 6?10 a, were divided into a PCOS group and a control group. The PCOS group were given two cycles of subcutaneous injections of propionic acid testosterone (PAT), 3.5 mg/kg body weight, on day 1, day 3, and day 5 of the menstrual cycle, respectively, and then given muscle injections of human chorionic gonadotropin (HCG), 350 IU/kg body wtight, on day 7, day 9, and day 11, respectively. Results showed that high levels of serum LH and T [(5.35±0.17) IU/L and (7.58±0.14) ng/mL, respectively], and a high ratio value of LH/FSH (5.35/1.30=4.12) were observed in the PCOS group. No significant differences were found in serum FSH, E2, and P in the PCOS group compared with those of the control. Polycystic ovaries in the PCOS monkeys were recorded by live ultrasound. The blastocysts rates of the PCOS vs. the control were 23.53% vs. 66.67%, and there was a significant difference between the two groups. This study shows that PAT coupled with HCG can induce PCOS in rhesus monkeys in the short term. The reproductive features of PCOS monkeys were similar to those of PCOS patients.
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  • [1] Abbott DH, Dumesic DA, Eisner JR, Colman RJ, Kemnitz JW. 1998. Insights into the development of PCOS from studies of prenatally androgenized female rhesus monkeys
    [J]. Trends Endocrinol Metab, 9(2): 62-67.
    [3] Abbott DH, Foong SC, Barnett DK, Dumesic DA. 2004. Nonhuman primates contribute unique understanding to anovulatory infertility in women
    [J]. ILAR J, 45(2): 116-131.
    [5] Abbott DH, Barnett DK, Bruns CM, Schramm RD, Dumesic DA. 2005. Androgen excess fetal programming of female reproduction: a developmental aetiology for polycystic ovary syndrome
    [J]. Hum Reprod Update, 11(4): 357-374.
    [7] Abbott DH, Dumesic DA, Levine JE, Dunaif A, Padmanabhan V. 2006. Animal models and fetal programming of PCOS
    [M] // Azziz R, Nestler JE, Dewailly D. Contemporary Endocrinology: Androgen Excess Disorders in Women: Polycystic Ovary Syndrome and Other Disorders. 2nd ed. Totowa, NJ: Humana Press Inc., 259-272.
    [9] Arifin E, Shively CA, Register TC, Cline JM. 2008. Polycystic ovary syndrome with endometrial hyperplasia in a cynomolgus monkey (Macaca fascicularis)
    [J]. Vet Pathol, 45(4): 512-515.
    [11] Blekhman R, Man O, Herrmann L, Boyko AR, Indap A, Kosiol C, Bustamante CD, Teshima KM, Przeworski M. 2008. Natural selection on genes that underlie human disease susceptibility
    [J]. Curr Biol, 18(12): 883-889.
    [13] Cano F, García-Velasco JA, Millet A, Remohí J, Simón C, Pellicer A. 1997. Oocyte quality in polycystic ovaries revisited: identification of a particular subgroup of women
    [J]. J Assist Reprod Genet, 14(5): 254-260.
    [15] Chen ZJ, Zhao JL, Zhou FR, Li Y, Zhao LX, Ma ZX. 2005. The primary investigation of prevalence of the polycystic ovary syndrome in general Han ethnic women in Jinan city
    [J]. Prog Obstet Gyneol, 14(6): 442-444. (in Chinese)
    [17] Dumesic DA, Abbott DH, Padmanabhan V. 2007. Polycystic ovary syndrome and its developmental origins
    [J]. Rev Endocr Metab Disord, 8(2): 127-141.
    [19] Gougeon A. 1996. Regulation of ovarian follicular development in primates: facts and hypothesis
    [J]. Endocr Rev, 17(2): 121-155.
    [21] Heijnen E, Eijkemans M, Hughes E, Laven J, Macklon N, Fauser B. 2006. A meta-analysis of outcomes of conventional IVF in women with polycystic ovary syndrome
    [J]. Human Reprod Update, 12(1): 13-21.
    [23] Hwang JL, Seow KM, Lin YH, Hsieh BC, Huang LW, Chen HJ, Huang SC, Chen CY, Chen PH, Tzeng CR. 2005. IVF versus ICSI in sibling oocytes from patients with polycystic ovarian syndrome: a randomized controlled trial
    [J]. Hum Reprod, 20(5): 1261-1265.
    [25] Jakimiuk AJ, Weitsman SR, Brzechffa PR, Magoffin DA. 1998. Aromatase mRNA expression in individual follicles from polycystic ovaries
    [J]. Mol Hum Reprod, 4(1): 1-8.
    [27] Jimenez DF, Leapley AC, Lee CI, Ultsch MN, Tarantal AF. 2005. Fetal CD34+ cells in the maternal circulation and long-term microchimerism in rhesus monkeys (Macaca mulatta)
    [J]. Transplantation, 79(2): 142-146.
    [29] Kodama H, Fukuda J, Karube H, Matsui T, Shimizu Y, Tanaka T. 1995. High incidence of embryo transfer cancellations in patients with polycystic ovarian syndrome
    [J]. Hum Reprod, 10(8): 1962-1967.
    [31] Lee CI, Fletcher MD, Tarantal AF. 1995. Effect of age on the frequency, cell cycle, and lineage maturation of rhesus monkey (Macaca mulatta) CD34+ and hematopoietic progenitor cells
    [J]. Pediatr Res, 58(2): 315-322.
    [33] Lin L, Ding Y. 2008. Approach the characteristics and treatments of the puberty polycystic ovary syndrome of the Uygurs and Hans in Xinjiang
    [J]. Prog Obstet Gynecol, 17(4): 281-285. (in Chinese)
    [35] Lobo RA. 1991. The syndrome of hyperandrogenic chronic anovulation
    [M]// Mishell DR Jr, Davajan V, Lobo RA. Infertility, Contraception and Reproductive Endocrinology. 3rd ed. Cambridge: Blackwell Scientific Publications. 447-487.
    [37] Lu XE, Yang XF, Li MG, Zhou FZ, Zhu YM, Huang HF. 2006. Outcome of in vitro fertilization-embryo transfer in treatment of polycystic ovarian syndrome
    [J]. J Zhejiang Univ:Med Sci, 35(3): 319-322. (in Chinese)
    [39] Ludwig M, Finas DF, Al-Hasani S, Diedrich K, Ortmann O. 1999. Oocyte quality and treatment outcome in intracytoplasmic sperm injection cycles of polycystic ovarian syndrome patients
    [J]. Hum Reprod, 14(2): 354-358.
    [41] Manner?s L, Cajander S, Holmäng A, Seleskovic Z, Lystig T, Lönn M, Stener-Victorin E. 2007. A new rat model exhibiting both ovarian and metabolic characteristics of polycystic ovary syndrome
    [J]. Endocrinology, 148(8): 3781-3791.
    [43] Rosenfield RL. 2007. Identifying children at risk for polycystic ovary syndrome
    [J]. J Clin Endocrinol Metab, 92(3): 787-796.
    [45] Sengoku K, Tamate K, Takuma N, Yoshida T, Goishi K, Ishikawa M. 1997. The chromosomal normality of unfertilized oocytes from patients with polycystic ovarian syndrome
    [J]. Hum Reprod, 12(3):474-477.
    [47] Tarantal AF. 1992. Sonographic assessment of nongravid female macaques (Macaca mulatta and Macaca fascicularis)
    [J]. J Med Primatol, 21(6): 308-315.
    [49] Tarantal AF, Gargosky SE. 1995. Characterization of the insulin-like growth factor (IGF) axis in the serum of maternal and fetal macaques (Macaca mulatta and Macaca fascicularis): A crosssectional study
    [J]. Growth Reg, 5(4): 190-198.
    [51] Tarantal AF, Laughlin LS, Dieter J, Tieu J, Hendrickx AG, Overstreet JW, Lasley BL. 1997. Pregnancy detection by ultrasound and chorionic gonadotropin during the peri-implantation period in the macaque (Macaca fascicularis)
    [J]. Early Pregnancy, 3(4): 281- 290.
    [53] The Rotterdam ESHRE/ASRM-sponsored PCOS consensus workshop group. 2004. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS)
    [J]. Hum Reprod, 19(1): 41-47.
    [55] Vendola KA, Zhou J, Adesanya OO, Weil SJ, Bondy CA. 1998. Androgens stimulate early stages of follicular growth in the primate ovary
    [J]. J Clin Invest, 101(2): 2622-2629.
    [57] Wagner JE, Kavanagh K, Ward GM, Auerbach BJ, Harwood HJ Jr, Kaplan JR. 2006. Old world nonhuman primate models of type 2 diabetes mellitus
    [J]. ILAR J, 47(3): 259-271.
    [59] Waldstreicher J, Santoro NF, Hall JE, Filicori M, Crowley WF Jr. 1998. Hyperfunction of the hypothalamic-pituitary axis in women with polycystic ovarian disease: indirect evidence for partial gonadotroph desensitization
    [J]. J Clin Endocrinol Metab, 66(1): 165-172.
    [61] Wu JM, Zelinski MB, Ingram DK, Ottinger MA. 2005. Ovarian aging and menopause: current theories, hypotheses, and research models
    [J]. Exp Biol Med, 230(11): 818-828.
    [63] Xu XH, Tan YC, Shi YH, Wang B, Ju XQ, Zheng QM, Hao CF, Chen ZJ. 2009. Different types of menstrual cycle and their significance in Chinese women diagnosed with polycystic ovary syndrome according to the Rotterdam consensus criteria
    [J]. Natl Med J Chn, 89(37): 2604-2606. (in Chinese)
    [65] Yang S, He X, NiuY, Hildebrandt TB, Jewgenowc K, Goeritz F, Tang X, Chang Y, Zhou Q, Ji W. 2009. Ovarian response to gonadotropin stimulation in juvenile rhesus monkeys
    [J]. Theriogenology, 72(2): 243-250.
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Reproductive traits of polycystic ovary syndrome in female rhesus monkeys

doi: 10.3724/SP.J.1141.2012.01037
Funds:  This work was supported by Yunnan Key Laboratory of Animal Reproductive Biology(2010-03)

Abstract: The objective of this study was to set up a rhesus monkey model of polycystic ovary syndrome (PCOS), which is globally prevalent among reproductive-aged human women, and to understand the reproductive traits of PCOS female monkeys. Six adult female rhesus monkeys aged 6?10 a, were divided into a PCOS group and a control group. The PCOS group were given two cycles of subcutaneous injections of propionic acid testosterone (PAT), 3.5 mg/kg body weight, on day 1, day 3, and day 5 of the menstrual cycle, respectively, and then given muscle injections of human chorionic gonadotropin (HCG), 350 IU/kg body wtight, on day 7, day 9, and day 11, respectively. Results showed that high levels of serum LH and T [(5.35±0.17) IU/L and (7.58±0.14) ng/mL, respectively], and a high ratio value of LH/FSH (5.35/1.30=4.12) were observed in the PCOS group. No significant differences were found in serum FSH, E2, and P in the PCOS group compared with those of the control. Polycystic ovaries in the PCOS monkeys were recorded by live ultrasound. The blastocysts rates of the PCOS vs. the control were 23.53% vs. 66.67%, and there was a significant difference between the two groups. This study shows that PAT coupled with HCG can induce PCOS in rhesus monkeys in the short term. The reproductive features of PCOS monkeys were similar to those of PCOS patients.

TANG Xiang-Hui, CAO Yue-Ling, YANG Ze-Xing, ZHAO Fu-Xian. Reproductive traits of polycystic ovary syndrome in female rhesus monkeys. Zoological Research, 2012, 33(1): 37-42. doi: 10.3724/SP.J.1141.2012.01037
Citation: TANG Xiang-Hui, CAO Yue-Ling, YANG Ze-Xing, ZHAO Fu-Xian. Reproductive traits of polycystic ovary syndrome in female rhesus monkeys. Zoological Research, 2012, 33(1): 37-42. doi: 10.3724/SP.J.1141.2012.01037
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