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SUN Yong-Mei, YANG Jian-Zhen, SUN Hua-Ying, MA Yuan-Ye, WANG Jian-Hong. Establishment of tree shrew chronic morphine dependent model. Zoological Research, 2012, 33(1): 14-18. doi: 10.3724/SP.J.1141.2012.01014
Citation: SUN Yong-Mei, YANG Jian-Zhen, SUN Hua-Ying, MA Yuan-Ye, WANG Jian-Hong. Establishment of tree shrew chronic morphine dependent model. Zoological Research, 2012, 33(1): 14-18. doi: 10.3724/SP.J.1141.2012.01014

Establishment of tree shrew chronic morphine dependent model

doi: 10.3724/SP.J.1141.2012.01014
  • Received Date: 2011-12-19
  • Rev Recd Date: 2012-01-05
  • Publish Date: 2012-02-22
  • The clinical use of morphine to reduce pain is limited because of its drug tolerance, dependence and addiction. In the present study, the tree shrews (Tupaia belangeri chinensis) developed morphine tolerance and chronic morphine dependence by morphine injections with increasing doses (5, 10, 15, 20 mg/kg body weight for 7 days). Meanwhile, the naloxone (1.25 mg/kg body weight)-induced conditioned place aversion (CPA) and the withdrawal symptom were also found. The tree shrew model of chronic morphine dependence can be used to investigate the withdrawal symptoms and to select potential withdrawal symptoms reducing drugs in the future.
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  • [1] Azar MR, Jones BC, Schulteis G. 2003. Conditioned place aversion is a highly sensitive index of acute opioid dependence and withdrawal
    [J]. Psychopharmacology, 170(1): 42-50.
    [3] Deroche-Gamonet V, Belin D, Piazza PV. 2004. Evidence for addiction-like behavior in the rat
    [J]. Science, 305(5686): 1014-1017.
    [5] John R. Nichols JR, Hsiao S. 1967. Addiction liability of albino rats: breeding for quantitative differences in morphine drinking
    [J]. Science, 157(3788): 561-563.
    [7] Leshner AI. 1997. Addiction is a brain disease, and it matters
    [J]. Science, 278(5335): 45-47.
    [9] Li Y, Hao W, Wang XY, Deng H.Q. 2006. Developing the conditioned place aversion rat model produced by naloxone-precipitated withdrawal from chronic morphine dependence
    [J]. Chn J Clin Psychol, 14(3): 275-278.
    [11] [李毅, 郝伟, 王绪轶, 邓慧琼, 2006. 慢性吗啡成瘾大鼠纳洛酮催 瘾戒断后CPA 模型的建立
    [J]. 中国临床心理学杂志, 14(3): 275-277.]
    [13] Martell BA, O'Connor PG, Kerns RD, Becker WC, Morales KH, Kosten TR, Fiellin DA. 2007. Systematic review: opioid treatment for chronic back pain: prevalence, efficacy, and association with addiction
    [J]. Ann Intern Med, 146(2): 116-127.
    [15] Myers KM, Carlezon WA Jr. 2010. D-cycloserine facilitates extinction of naloxone-induced conditioned place aversion in morphine-dependent rats
    [J]. Biol Psychiatry, 67(1): 85-87.
    [17] Peng YZ, Ye ZZ, Zou RJ, Wang YX, Tian BP, Ma YY, Shi LM. 1991. Biology of Chinese Tree Shrews
    [M]. Kunming, China: Yunnan Science and Technology Press.
    [19] [彭燕章, 叶智彰, 邹如金,王应祥, 田保平, 马原野, 施立明. 1991. 树鼩生物学. 昆明: 云南科技出版社.]
    [20] Sargis EJ. 2004. New views on tree shrews: the role of Tupaiids in primate supraordinal relationships
    [J]. Evol Anthropol, 13(2): 56-66.
    [22] Schulteis G, Morse AC, Liu J. 2004. Conditioning processes contribute to severity of naloxone-precipitated withdrawal from acute opioid dependence
    [J]. Psychopharmacology, 175(4): 463-472.
    [24] van Ree JM, Gerrits MAFM, Vanderschuren LJMJ. 1999. Opioids, reward and addiction: an encounter of biology, psychology, and medicine
    [J]. Pharmacol Rev, 51(2): 341-396.
    [26] Waldhoer M, Bartlett SE, Whistler JL. 2004. Opioid receptors
    [J]. Annu Rev Biochem, 73: 953-990.
    [28] Wiens F, Zitzmann A, Lachance MA, Yegles M, Pragst F, Wurst FM, holst D, Guan SL, Spanagel R. 2008. Chronic intake of fermented floral nectar by wild tree shrews
    [J]. Proc Natl Acad Sci USA, 105(30): 10426-10431.
    [30] Xu W, Luo XJ, Tan BP, Zheng XG, Yang XY, Sui N. 2004. Effect of naloxone on conditioned place aversion in morphine-treated rats
    [J]. Chn J Pain Med, 10(2): 105-109.
    [32] [须卫, 罗小景, 谭北平, 邓希耕, 杨晓燕, 隋南. 2004. 纳洛酮诱发吗啡成瘾大鼠CPA 模型的建立
    [J]. 中国疼痛医学杂志, 10((2): 105-109.]
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Establishment of tree shrew chronic morphine dependent model

doi: 10.3724/SP.J.1141.2012.01014

Abstract: The clinical use of morphine to reduce pain is limited because of its drug tolerance, dependence and addiction. In the present study, the tree shrews (Tupaia belangeri chinensis) developed morphine tolerance and chronic morphine dependence by morphine injections with increasing doses (5, 10, 15, 20 mg/kg body weight for 7 days). Meanwhile, the naloxone (1.25 mg/kg body weight)-induced conditioned place aversion (CPA) and the withdrawal symptom were also found. The tree shrew model of chronic morphine dependence can be used to investigate the withdrawal symptoms and to select potential withdrawal symptoms reducing drugs in the future.

SUN Yong-Mei, YANG Jian-Zhen, SUN Hua-Ying, MA Yuan-Ye, WANG Jian-Hong. Establishment of tree shrew chronic morphine dependent model. Zoological Research, 2012, 33(1): 14-18. doi: 10.3724/SP.J.1141.2012.01014
Citation: SUN Yong-Mei, YANG Jian-Zhen, SUN Hua-Ying, MA Yuan-Ye, WANG Jian-Hong. Establishment of tree shrew chronic morphine dependent model. Zoological Research, 2012, 33(1): 14-18. doi: 10.3724/SP.J.1141.2012.01014
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