Volume 32 Issue 4
Jul.  2011
Turn off MathJax
Article Contents
WANG Xiao-Qin, WANG Gong-Wu, DUAN Qiu-Yan, TENG Shi-Tong. Impairment effects of tail suspension stress on spatial memory and its reversal learning in mice. Zoological Research, 2011, 32(4): 428-434. doi: 10.3724/SP.J.1141.2011.04428
Citation: WANG Xiao-Qin, WANG Gong-Wu, DUAN Qiu-Yan, TENG Shi-Tong. Impairment effects of tail suspension stress on spatial memory and its reversal learning in mice. Zoological Research, 2011, 32(4): 428-434. doi: 10.3724/SP.J.1141.2011.04428

Impairment effects of tail suspension stress on spatial memory and its reversal learning in mice

doi: 10.3724/SP.J.1141.2011.04428
More Information
  • Author Bio:

    WANG Xiao-Qin,E-mail: xiaoqinwang2001@yahoo.com.cn

  • Corresponding author: WANG Gong-Wu2
  • Received Date: 2011-05-31
  • Rev Recd Date: 2011-06-28
  • Publish Date: 2011-08-22
  • Present work investigated the effects of tail suspension stress (TSS) on spatial memory acquisition, consolidation, and its reversal learning in mice. Eighty-one adult male KM mice were divided into four groups (each group including a TSS subgroup and its control subgroup): absolute spatial memory acquisition and consolidation groups (group AA and CA); relative spatial memory acquisition and consolidation groups (group AR and CR). TSS (20 min) was performed immediately before (acquisition) or after (consolidation) a daily training. Results showed that there was no significant difference between control animals and TSS animals in each group in early spatial memory training days (5-8 d of training). Along with training, the performance of control animals improved significantly, but the performance of TSS animals improved slightly (group AA, CA and AR) or even did not change (group CR) (P < 0.01). Reversal learning was also impaired in TSS animals (P < 0.01). The results indicated that TSS could impair spatial memory acquisition, consolidation and reversal learning (especially the relative spatial memory consolidation and its reversal learning) in mice.
  • loading
  • [1]
     Arnsten AF. 2009. Stress signalling pathways that impair prefrontal cortex structure and function [J]. Nat Rev Neurosci, 10(6): 410-422.
     Bi L, Li YX, He M, Huang ZM, Zhao DS, Lan JQ. 2004. Ultrastructural changes in cerebral cortex and cerebellar cortex of rats under simulated weightlessness [J]. Space Med Med Eng: Beijing, 17(3): 180-183. 毕蕾, 李英贤, 何玫, 黄增明, 赵定胜, 蓝景全. 2004. 模拟失重对大鼠大脑和小脑皮层超微结构的影响. 航天医学与医学工程, 17(3): 180-183.]
     Chen J, Ma J, Ding ZP, Zhang LF. 1993. A modified tail-suspension model for simulating long-term weightlessness
    [J]. Chn J Space Sci, 13(2): 159-162. 陈杰, 马进, 丁兆平, 张立藩. 1993. 一种模拟长期失重影响的大鼠尾部悬吊模型. 空间科学学报, 13(2): 159-162.]
     Cryan JF, Mombereau C, Vassout A. 2005. The tail suspension test as a model for assessing antidepressant activity: review of pharmacological and genetic studies in mice [J]. Neurosci Biobehav Rev, 29(4-5): 571-625.
     Cui YP, Zhang F, Wang BC, Song YT, Yang WP, Zhu YL, Hong F. 2008. Comparative research of the effects of overload training and simulated weightlessness on the HPA axis in rats [J]. Chn J Sports Med, 27(1): 90-92. [崔玉鹏, 张凡, 王宝成, 宋玉涛, 杨卫平, 朱一力, 洪峰. 2008. 大负荷运动训练与模拟失重对大鼠HPA轴影响的对比研究. 中国运动医学杂志, 27(1): 90-92.]
     Elzinga BM, Bakker A, Bremner JD. 2005. Stress-induced cortisol elevations are associated with impaired delayed, but not immediate recall [J]. Psychiatry Res, 134(3): 211-223.
     Haggstrom JE, Sjoquist B, Eckernas SA, Ingvast A, Gunne LM. 1984. Discrete regional distribution of biochemical markers for the dopamine, noradrenaline, serotonin, GABA and acetylcholine systems in the monkey brain (Cebus Apella). Effects of stress [J]. Acta Physiol Scand Suppl, 534: 1-27.
     Lee T, Jarome T, Li SJ, Kim JJ, Helmstetter FJ. 2009. Chronic stress selectively reduces hippocampal volume in rats: a longitudinal magnetic resonance imaging study
    [J]. Neuroreport, 20(17): 1554-1558.
     McEwen BS. 2001. Plasticity of the hippocampus: adaptation to chronic stress and allostatic load [J]. Ann N Y Acad Sci, 933: 265-277.
     Meng JR, Shen XY, Dong Q, Chen JH, Xiang QL, Wang DS. 1997. Effect of 7-day simulated weightlessness on hunman hemorheology [J]. J Chn Microcirc, 1(2): 77-79.
    [孟京瑞, 沈羡云, 董颀, 陈建和, 向求鲁, 汪德生. 1997. 7天模拟失重对人体血液流变性的影响. 中国微循环, 1(2): 77-79.]
     Mitsushima D, Takase K, Funabashi T, Kimura F. 2008. Gonadal steroid hormones maintain the stress-induced acetylcholine release in the hippocampus: simultaneous measurements of the extracellular acetylcholine and serum corticosterone levels in the same subjects [J]. Endocrinology, 149(2): 802-811.
     Mizoguchi K, Yuzurihara M, Ishige A, Sasaki H, Chui DH, Tabira T. 2000. Chronic stress induces impairment of spatial working memory because of prefrontal dopaminergic dysfunction [J]. J Neurosci, 20(4): 1568-1574.
     Morey-Holton ER, Wronski TJ. 1981. Animal models for simulating weightlessness [J]. Physiologist, 24(Suppl.): S45-46.
     Morey-Holton ER, Globus RK. 2002. Hindlimb unloading rodent model: technical aspects [J]. J Appl Physiol, 92(4): 1367-1377.
     Roozendaal B, McReynolds JR, Van der Zee EA, Lee S, McGaugh JL, McIntyre CK. 2009. Glucocorticoid effects on memory consolidation depend on functional interactions between the medial prefrontal cortex and basolateral amygdala [J]. J Neurosci, 29(45): 14299-14308.
     Seong E, Seasholtz AF, Burmeister M. 2002. Mouse models for psychiatric disorders [J]. Trends Genet, 18(12): 643-650.
     Shen XY, Lan JQ, Xiang QL, Meng JR, Wang YQ. 1989. Changes of rabbit brain microcirculation during simulated weightless [J]. Space Med Med Eng: Beijing, 2(2): 89-93, 151-152. [沈羡云, 蓝景全, 向求鲁, 孟京瑞, 王玉清. 1989. 模拟失重时兔脑微循环的变化. 航天医学与医学工程, 2(2): 89-93, 151-152.]
     Shen XY. 2003. Expectation of the study of weightlessness physiology in the 21st century [J]. Space Med Med Eng: Beijing, 16(Suppl.): 573-576. [沈羡云. 2003. 21 世纪失重生理学研究的展望. 航天医学与医学工程, 16(增刊): 573-576.]
     Sun XQ, Xu ZP, Zhang S, Wu B, Cao XS, Wu P. 2006. Effects of +Gx exposure after simulated weightlessness on glial fibrillary acidic protein (GFAP) expression of brain in rats [J]. Space Med Med Eng: Beijing,19(1): 19-22. [孙喜庆, 徐志鹏, 张舒, 吴斌, 曹新生, 吴萍. 2006. 模拟失重后高+Gx作用对大鼠脑胶质细胞酸性蛋白表达的影响. 航天医学与医学工程, 19(1): 19-22.]
     Sun XQ, Xu ZP, Zhang S, Cao XS, Liu TS. 2009. Simulated weightlessness aggravates hypergravity-induced impairment of learning and memory and neuronal apoptosis in rats [J]. Behav Brain Res, 199(2): 197-202.
     Tollenaar MS, Elzinga BM, Spinhoven P, Everaerd WA. 2008. The effects of cortisol increase on long-term memory retrieval during and after acute psychosocial stress [J]. Acta Psychol :Amst, 127(3): 542-552.
     Wang YF, Zhu B, Wu J, Wang L, Cai JX. 2005. The dopamine mechanism of impairment effect of tail-suspension on passive avoidance task in mice
    [J]. Neurosci Bull, 21(Suppl.): 149. [王永富, 朱壁, 吴晶, 王磊, 蔡景霞. 2005. 悬尾应激损伤小鼠被动回避作业的多巴胺受体机制. 神经科学通报, 21(增刊): 149.]
     Wang YF, Cai JX, Xu L. 2007. I. Mechanism study on the anti-stress-like and anti-depressant-like effects of phenchlobenpyrrone, II. Synaptic plasticity mechanism of EGb 761- or Chinese-Tranditional-Medicine- Fufang on age-induced cognitive deficit in rats [PhD]
    [D]. Beijing: Graduate University of Chinese Academy of Sciences and Kunming Institute of Zoology, Chinese Academy of Sciences. [王永富, 蔡景霞, 徐林. 2007. Ⅰ、KMB-009改善心理应激所致认知障碍和抑郁样行为的研究 Ⅱ、银杏叶提取物及复方制剂改善老年鼠空间学习记忆突触可塑性机理
    [博士]. 北京: 中国科学院研究生院 中国科学院昆明动物研究所.]
     Wu DW, Shen XY. 2000. Changes of cerebral circulation during weightlessness or simulated weightlessness [J]. Space Med Med Eng: Beijing, 13(5): 386-390.
    [吴大蔚, 沈羡云. 2000. 失重或模拟失重时脑循环的改变. 航天医学与医学工程, 13(5): 386-390.]
     Wu DW, Shen XY, Dong Q, Wang SP, Cheng ZH, Zhang SJ. 2000. Effects of tail suspension on learning and memory function of mice [J]. Space Med Med Eng: Beijing, 13(4): 244-248. [吴大蔚, 沈羡云, 董颀, 王圣平, 程张红, 张淑静. 2000. 尾部悬吊对小鼠学习记忆功能的影响. 航天医学与医学工程, 13(4): 244-248.]
     Xu ZP, Sun XQ, Liu TS, Wu B, Zhang S, Wu P. 2005. Effects of high +Gx during simulated spaceship emergency return on learning and memory in rats [J]. Space Med Med Eng:Beijing, 18(1): 1-5. [徐志鹏, 孙喜庆, 刘挺松, 吴斌, 张舒, 吴萍. 2005. 模拟飞船应急返回时高+Gx对大鼠学习记忆功能的影响. 航天医学与医学工程, 18(1): 1-5.]
     Yang JJ, Shen Z. 2003. Effects of microgravity on human cognitive function in space flight [J]. Space Med Med Eng :Beijing, 16(6): 463-467. [杨炯炯, 沈政. 2003. 载人航天中微重力环境对认知功能的影响. 航天医学与医学工程, 16(6): 463-467.]
     Yuen EY, Liu W, Karatsoreos IN, Feng J, McEwen BS, Yan Z. 2009. Acute stress enhances glutamatergic transmission in prefrontal cortex and facilitates working memory [J]. Proc Natl Acad Sci U S A, 106(33): 14075-14079.
     Zheng LJ, Liu L, Zhang T, Lü BC. 2008. The study of the hippocampal dentate gyrus neurogenesis after simulated weightlessness in the rat [J]. Chn J Neuroanat, 24(3): 287-291. [郑丽娟, 刘立, 张婷, 吕伯昌. 2008. 模拟失重后大鼠海马齿状回神经发生的实验研究. 神经解剖学杂志, 24(3): 287-291.]
  • Relative Articles

    [1] Guo-Xiao ZHENG, Jiang-Tao LIN, Wei-Hong ZHENG, Jing CAO, Zhi-Jun ZHAO. Energy intake, oxidative stress and antioxidant in mice during lactation. Zoological Research, 2015, 36(2): 95-102.
    [2] Yan-Mei CHEN, Yu FU, Jing HE, Jian-Hong WANG. Effects of cold narcosis on memory acquisition, consolidation and retrieval in honeybees (Apis mellifera). Zoological Research, 2014, 35(2): 118-123.  doi: 10.11813/j.issn.0254-5853.2014.2.118
    [3] Xiao-Qin WANG, Xian-Li LI, Gong-WuWANG. Effect of prefrontal infralimbic cortex GABAA receptor agitating on passive avoidance memory consolidation of rats. Zoological Research, 2013, 34(6): 589-595.  doi: 10.11813/j.issn.0254-5853.2013.6.0589
    [4] Yao-Dong FAN, Hai-Chen NIU, Tanzeel Huma, Ling LI, Gui-Mei WANG, Li-Qi XU, He REN, Yuan-Ye MA, Hua-Lin YU. Blockage of glucocorticoid receptors during memory acquisition, retrieval and reconsolidation prevents the expression of morphine-induced conditioned place preferences in mice. Zoological Research, 2013, 34(E1): 5626-E.  doi: 10.3724/SP.J.1141.2013.E01E26
    [5] HE Xiong, ZHONG Zhao-Ming, CHE Yi. Locomotor activity and learning and memory abilities in Alzheimer’s disease induced by Aluminum in an acid environment in Zebrafish. Zoological Research, 2012, (2): 231-236.  doi: 10.3724/SP.J.1141.2012.02231
    [6] BIAN Hui, FANG Song, MIAO Ying-Da, YU Hua-Lin. Influences of two different training paradigms on spatial learning and memory performance of hippocampal injured rats. Zoological Research, 2012, (2): 237-240.  doi: 10.3724/SP.J.1141.2012.02237
    [7] WANG Jing, ZHOU Qi-Xin, TIAN Men, YANG Yue-Xiong, XU Lin. Tree shrew models: A chronic social defeat model of depression and a one-trial captive conditioning model of learning and memory. Zoological Research, 2011, 32(1): 24-30.  doi: 10.3724/SP.J.1141.2011.01024
    [8] MAO Yu, YANG Shang-Chuan, LIU Chang, MA Yuan-Ye, HU Xin-Tian. Effects of propranolol on acquisition and retrieval of morphine- induced conditioned place preference memories in ICR mice. Zoological Research, 2011, 32(6): 670-674.  doi: 10.3724/SP.J.1141.2011.06670
    [9] ZENG Yu, ZHANG Xin-Wen, ZHU Guang-Jian, GONG Yan-Yan, YANG Jian, ZHANG Li-Biao, *. Influence of Landmarks on Spatial Memory in Short-nosed Fruit Bat, Cynopterus sphinx. Zoological Research, 2010, 31(2): 163-168.  doi: 10.3724/SP.J.1141.2010.02163
    [10] LIU Xiao-fen, YAN Zi-li, WANG Jian-hong, HU Xin-tian, MA Yuan-ye. Effects of Withdrawal on Y-maze Spatial Recognition Memory in Mice after Long-term Morphine Injection. Zoological Research, 2009, 30(2): 199-203.  doi: 10.3724/SP.J.1141.2009.02199
    [11] SHI Jun-wei, ZOU Hong, JIN Mei-lei. Assessing Exploratory Behavior and Memory in ICR, BALB/c and C57BL/6 Mice Using Habituation. Zoological Research, 2008, 29(1): 49-55.
    [12] HE Jing, CHEN Yan-mei, WANG Jian-hong, MA Yuan-ye. Effect of Co-administration of Morphine and Cholinergic Antagonists on Y-maze Spatial Recognition Memory Retrieval and Locomotor Activity in Mice. Zoological Research, 2008, 29(6): 613-620.  doi: 10.3724/SP.J.1141.2008.06613
    [13] CHE Yi, CUI Yong-hua, ZHU Yu-fang, XUE Zhi-mou. Founding of Object Recognition Learning Paradigm in KM Mice and Its Application in Detecting Memory Impaired Properties of Compounds. Zoological Research, 2007, 28(5): 497-500.
    [14] ZHOU Xian-qing, QIAO Xin. Effects of Vitamin C Polyphosphate on Anti-heat Stress Ability in Mice. Zoological Research, 2004, 25(5): 447-451.
    [15] MEI Zhen-tong. Study on Learning and Memory of Mutant Mice. Zoological Research, 2000, 21(1): 2-6.
    [16] CHEN Zhong, LI Shu-zheng, ZHU Jian-qin. Inhibitory Effect of Acute Heat Stress on High Affinitive Gaba Uptake in The Brain of Mice. Zoological Research, 1999, 20(2): 156-157.
    [17] ZHANG Zi-gui, DU Hong-yan, ZHANG Wei-nin, WU Fu-mei. Learning-Memory Dysfunction Caused by High Ca[2+] level and Changes of the Synaptic Interface-Structural Parameters. Zoological Research, 1998, 19(2): 120-124.
    [18] CAI Jing-xia, XU Lin, HU Xin-tian, MA Yuan-ye, SU Wei, XIAO Kun-yuan. The Relation Between Evolution of Spatial working Memory Function and of Morphology of The Dorsolateral Prefrontal Cortex Among The Rhesus Monkey,Slow Loris and Tree Shrew. Zoological Research, 1993, 14(2): 158-165.
    [19] Fang congyi, Liu cheng, Qi huixin, Zheng jianbiao, Chen ling, Xu huiming, Xiang zhongming, Song benbo. The hippocampal formation and learning and memory of dark avoidance behavior in rats IV. effects of colchicine microinjected into various parts of hippocampal formation. Zoological Research, 1988, 9(1): 79-86.
    [20] LIU Ren-yi, HSU Ping-hsuan. Effects on Learning and Memory of Electrolytic Lesions of Hippocampus in Rats. Zoological Research, 1982, 3(4): 385-392.
  • 加载中


    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Article Metrics

    Article views (1660) PDF downloads(1562) Cited by()
    Proportional views


    DownLoad:  Full-Size Img  PowerPoint