Volume 32 Issue 3
May  2011
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QI Cui, ZHANG Wei-Wei, WANG Fei, BAO Chao-Fei, WANG Xin-Wei, LI Xiao-Nan, YU Xiao-Q. Acute effects of IL-1β on sodium current in cortical neurons of rats. Zoological Research, 2011, 32(3): 323-328. doi: 10.3724/SP.J.1141.2011.03323
Citation: QI Cui, ZHANG Wei-Wei, WANG Fei, BAO Chao-Fei, WANG Xin-Wei, LI Xiao-Nan, YU Xiao-Q. Acute effects of IL-1β on sodium current in cortical neurons of rats. Zoological Research, 2011, 32(3): 323-328. doi: 10.3724/SP.J.1141.2011.03323

Acute effects of IL-1β on sodium current in cortical neurons of rats

doi: 10.3724/SP.J.1141.2011.03323
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  • Author Bio:

    QI Cui

  • Received Date: 2010-09-25
  • Rev Recd Date: 2011-01-28
  • Publish Date: 2011-06-22
  • Interleukin-1β (IL-1β) is an important proinflammatory cytokine that plays a key role in injuries and diseases of the central nervous system (CNS). The voltage-gated Na+channel is the most important ion channel of neurons, and is essential for regenerative action potential (AP). The Na+ channel also contributes to many diseases of the brain. However, relations between IL-1β and central Na+ channels remain unreported. In this study, whole cell patch-clamp recording was used to investigate the acute effects of IL-1β (10 ng/mL) on voltage-dependent Na+ currents and AP of cultured cortical neurons from rats. Results showed that the half-activation voltage of Na+ channels and the threshold of AP, but not the amplitude, slope factor of activation, and inactivation properties, were affected by IL-1β. These data suggest that increased IL-1β in injury and disease may upregulate the excitability of neurons, and thereby exacerbate neurotoxicity.
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