Volume 32 Issue 3
May  2011
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XIA Ji-Liang, HAO Xiang-Fen, ZENG Xiao-Ming, JIN Li-Sha, ZHOU Tong, LI Xue-Jia. Correlation between cardiovascular risk factors and the expression of cardiovascular disease related genes in cynomolgus monkeys. Zoological Research, 2011, 32(3): 293-299. doi: 10.3724/SP.J.1141.2011.03293
Citation: XIA Ji-Liang, HAO Xiang-Fen, ZENG Xiao-Ming, JIN Li-Sha, ZHOU Tong, LI Xue-Jia. Correlation between cardiovascular risk factors and the expression of cardiovascular disease related genes in cynomolgus monkeys. Zoological Research, 2011, 32(3): 293-299. doi: 10.3724/SP.J.1141.2011.03293

Correlation between cardiovascular risk factors and the expression of cardiovascular disease related genes in cynomolgus monkeys

doi: 10.3724/SP.J.1141.2011.03293
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  • Author Bio:

    XIA Ji-Liang(1983-),E-mail:jiliangxia2009@163.com

  • Received Date: 2010-12-24
  • Rev Recd Date: 2011-03-10
  • Publish Date: 2011-06-22
  • The correlation between cardiovascular risk factors and cardiovascular disease related genes plays an important role in early-warning risk and early diagnosis. Thirty middle-aged male crab-eating macaques were fed a moderately atherogenic diet (0.053 mg cholesterol/kJ and 40% of calories as saturated fat) for twelve months. According to cardiovascular risk factors, we selected low-risk and high-risk crab-eating macaques, then analyzed the expression of 113 cardiovascular related genes by real-time PCR. A total of 65 genes were detected in peripheral blood leukocytes by real-time PCR. Sixteen up-regulated genes and nineteen down-regulated genes were detected in low-risk and high-risk crab-eating macaques compared to normal crab-eating macaques (P<0.05), in addition to fifteen genes that showed unique expression patterns (P<0.05). We also detected 42 genes in human peripheral blood leukocytes. The expression patterns of 22 genes were consistent between human and crab-eating macaques. These results narrowed the scope of genes for further research.
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