Volume 32 Issue 1
Jan.  2011
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XIA Hou-Jun, CHEN Ce-Shi. Progress of non-human primate animal models of cancers. Zoological Research, 2011, 32(1): 70-80. doi: 10.3724/SP.J.1141.2011.01070
Citation: XIA Hou-Jun, CHEN Ce-Shi. Progress of non-human primate animal models of cancers. Zoological Research, 2011, 32(1): 70-80. doi: 10.3724/SP.J.1141.2011.01070

Progress of non-human primate animal models of cancers

doi: 10.3724/SP.J.1141.2011.01070
Funds:  This work was supported in part by a grant from Yunnan Province High-Profile Talent Project (云南省高端人才计划2010CI114), and grants from Chinese Academy of Sciences (Basic frontier project , KSCX2-EW-J-23)
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  • Author Bio:

    XIA Hou-Jun

  • Corresponding author: CHEN Ce-Shi
  • Received Date: 2010-12-14
  • Rev Recd Date: 2011-01-07
  • Publish Date: 2011-02-22
  • Cancer is the second leading disease causing human death. Pre-clinical in vivo studies are essential for translating in vitro laboratory research results into the clinic. Rodents, including the mouse and rat, have been widely used for pre-clinical studies due to their small size, clear genetic backgrounds, rapid propagation, and mature transgenic technologies. However, because rodents are evolutionarily distinct from humans, many pre-clinical research results using rodent models cannot be reproduced in the clinic. Non-human primates (NHPs) may be better animal models than rodents for human cancer research because NHPs and humans share greater similarity in regards to their genetic evolution, immune system, physiology and metabolism. This article reviews the latest progress of cancer research in NHPs by focusing on the carcinogenesis of different NHPs induced by chemical and biological carcinogens. Finally, future research directions for the use of NHPs in cancer research are discussed.
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Progress of non-human primate animal models of cancers

doi: 10.3724/SP.J.1141.2011.01070
Funds:  This work was supported in part by a grant from Yunnan Province High-Profile Talent Project (云南省高端人才计划2010CI114), and grants from Chinese Academy of Sciences (Basic frontier project , KSCX2-EW-J-23)
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  • Corresponding author: CHEN Ce-Shi

Abstract: Cancer is the second leading disease causing human death. Pre-clinical in vivo studies are essential for translating in vitro laboratory research results into the clinic. Rodents, including the mouse and rat, have been widely used for pre-clinical studies due to their small size, clear genetic backgrounds, rapid propagation, and mature transgenic technologies. However, because rodents are evolutionarily distinct from humans, many pre-clinical research results using rodent models cannot be reproduced in the clinic. Non-human primates (NHPs) may be better animal models than rodents for human cancer research because NHPs and humans share greater similarity in regards to their genetic evolution, immune system, physiology and metabolism. This article reviews the latest progress of cancer research in NHPs by focusing on the carcinogenesis of different NHPs induced by chemical and biological carcinogens. Finally, future research directions for the use of NHPs in cancer research are discussed.

XIA Hou-Jun, CHEN Ce-Shi. Progress of non-human primate animal models of cancers. Zoological Research, 2011, 32(1): 70-80. doi: 10.3724/SP.J.1141.2011.01070
Citation: XIA Hou-Jun, CHEN Ce-Shi. Progress of non-human primate animal models of cancers. Zoological Research, 2011, 32(1): 70-80. doi: 10.3724/SP.J.1141.2011.01070
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