Volume 31 Issue 3
May  2010
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MENG Zhi-Qiang, ZHANG Yu-Hua, CHEN Nan-Hui, MIAO Ying-Da, HU Xin-Tian. Effects of Morphine on Pupil Light Reflex in Monkeys. Zoological Research, 2010, 31(3): 282-286. doi: 10.3724/SP.J.1141.2010.03283
Citation: MENG Zhi-Qiang, ZHANG Yu-Hua, CHEN Nan-Hui, MIAO Ying-Da, HU Xin-Tian. Effects of Morphine on Pupil Light Reflex in Monkeys. Zoological Research, 2010, 31(3): 282-286. doi: 10.3724/SP.J.1141.2010.03283

Effects of Morphine on Pupil Light Reflex in Monkeys

doi: 10.3724/SP.J.1141.2010.03283
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  • Corresponding author: HU Xin-Tian, MA Yuan-Ye
  • Received Date: 2009-11-17
  • Rev Recd Date: 2010-05-13
  • Publish Date: 2010-06-22
  • The pupil size of both human and other animals can be affected by light Many kinds of psychiatrical and psychological disorders associate with abnormal properties of pupil light reflex Thus, the properties of pupil light reflex function can reflect these kinds of mental disorders However, the effect of drug of abuse on pupil light reflex function is till unclear To quantificationally assess the effects of addictive drugs on pupil light reflex function, in the present study, we examined the effects of morphine on pupil diameter and pupil light reflex function in rhesus monkeys We measured the pupil diameter at different timing points after during morphine administration We found that morphine administration reduced the diameter of pupil and decreased the constriction rate Our present results provide an experimental support for applying pupil light reflex property as a reference in addicts’ detection.
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  • [1]
    Barbur JL, Moro S, Harlow JA, Lam BL, Liu M. 2004. Comparison of pupil responses to luminance and colour in severe optic neuritis [J]. Clin Neurophysiol, 115: 2650-2658.
    Bergamin O, Zimmerman MB, Kardon RH. 2003. Pupil light reflex in normal and diseased eyes: Diagnosis of visual dysfunction using waveform partitioning [J]. Ophthalmology, 110: 106-114.
    Deng YP, Sun GK, Wei W, Lu XX. 2002. Determination of abused drugs in urine samples[J].Chn J Drug Depend, 11(2): 117-119 [邓艳萍, 孙桂宽, 魏  伟, 吕宪祥. 2002. 尿样中滥用药物的检测分析. 中国药物依赖性杂志, 11(2): 117-119.]
    Fountoulakis K, Fotiou F, Iacovides A, Tsiptsios J, Goulas A, Tsolaki M, Ierodiakonou C. 1999. Changes in pupil reaction to light in melancholic patients [J]. Int J Psychophysiol, 31: 121-128.
    Gamlin PD, Zhang H, Harlow A, Barbur JL. 1998. Pupil responses to stimulus color, structure and light flux increments in the rhesus monkey [J]. Vision Res, 38: 3353-3358.
    Granholm E, Morris S, Galasko D, Shults C, Rogers E, Vukov B. 2003. Tropicamide effects on pupil size and pupillary light reflexes in Alzheimer's and Parkinson's disease [J]. Int J Psychophysiol, 47: 95-115.
    Kim M, Barrett AM, Heilman KM. 1998. Lateral asymmetries of pupillary responses [J]. Cortex, 34: 753-762.
    Knaggs RD, Crighton IM, Cobby TF, Fletcher AJ, Hobbs GJ.2004.The pupillary effects of intravenous morphine, codeine, and tramadol in volunteers [J]. Anesth Analg, 99: 108-112.
    Wang JK, Xu XF, Ma YY. 2005. Measurement of pupil reflex and psychiatric disorders [J]. J Int Psychiatry, 3: 156-159. [王继堃, 许秀峰, 马原野. 2005. 瞳孔的变化及测量与精神疾病的关系. 国际精神病学杂志, 3: 156-159.]
    Nagai M, Wada M, Sunaga N. 2002. Trait anxiety affects the pupillary light reflex in college students [J]. Neurosci Lett, 328: 68-70.
    Richman JE, McAndrew KG, Decker D, Mullaney SC. 2004. An evaluation of pupil size standards used by police officers for detecting drug impairment [J]. Optometry, 75: 175-182.
    Shi XM, Uchiyama H, Fukumoto I. 1998. A study for objective measurement of the senile dementia by light reflex [J]. JJME Biomed Eng, 12(9): 210-214.
    Steinhauer SR, Friedman D. 1995. Cognitive Psychophysiological Indicators of Vulnerability in Relatives of Schizophrenics[M]// Miller, GA. High Risk Research in Psychopathology, New York: Springer, 158-180.
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