Inhibition Effect of IL-1β on Calcium Channels Currents in Cultured Cortical Neurons of Rat
- Received Date: 2009-08-13
- Rev Recd Date: 1900-01-01
- Publish Date: 2010-02-22
Abstract: Interleukin-1β(IL-1β) is an important porinflammatory cytokine that exert wide biological functions in the central nervous system (CNS). Voltage-gated Ca2+ channels in plasma membrane are essential components of Ca2+ signal whose change on pathological conditions is closely related to processes of diseases. Although both IL-1βand Ca2+ channels have key roles in injury and disease of the brain, so far their relations have been reported in few studies. The effects of IL-1βon Ca2+ channels in cultured cortical neurons of rats were investigated using patch-clamp recording in present research. Our results showed that both 10 and 50 ng/mL of IL-1βtreatment inhibit the Ca2+ currents in time and dose dependent manner, without the change of activation properties of voltage-gated Ca2+ channels (VGCC)s.
|Citation:||ZHOU Chen*. Inhibition Effect of IL-1β on Calcium Channels Currents in Cultured Cortical Neurons of Rat. Zoological Research, 2010, 31(1): 89-93. doi: 10.3724/SP.J.1141.2010.01089|