Volume 31 Issue 1
Jan.  2010
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ZHU Lin, ZHANG Gao-Hong, ZHENG Yong-Tang. Application Studies of Animal Models in Evaluating Safety and Efficacy of HIV-1 Microbicides. Zoological Research, 2010, 31(1): 66-76. doi: 10.3724/SP.J.1141.2010.01066
Citation: ZHU Lin, ZHANG Gao-Hong, ZHENG Yong-Tang. Application Studies of Animal Models in Evaluating Safety and Efficacy of HIV-1 Microbicides. Zoological Research, 2010, 31(1): 66-76. doi: 10.3724/SP.J.1141.2010.01066

Application Studies of Animal Models in Evaluating Safety and Efficacy of HIV-1 Microbicides

doi: 10.3724/SP.J.1141.2010.01066
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  • Corresponding author: ZHENG Yong-Tang
  • Received Date: 2009-12-05
  • Rev Recd Date: 1900-01-01
  • Publish Date: 2010-02-22
  • As the HIV/AIDS pandemic continues unabated, novel prophylactic strategy for the spread of HIV are urgently needed. Topical microbicides are designed to prevent transmission of HIV when applied vaginally or rectally. Although there are many microbicide candidates in the pipeline, animal models for evaluating their safety and efficacy are urgently needed. On the basis of comparing the non-primate small animal models and the non-human primate animal models in evaluating safety and efficacy of HIV microbicides, this review summarizes the major advantages and disadvantages of the relevant animal models. The suggested direction of research that would benefit the development of microbicides is also reviewed.
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Application Studies of Animal Models in Evaluating Safety and Efficacy of HIV-1 Microbicides

doi: 10.3724/SP.J.1141.2010.01066
    Corresponding author: ZHENG Yong-Tang

Abstract: As the HIV/AIDS pandemic continues unabated, novel prophylactic strategy for the spread of HIV are urgently needed. Topical microbicides are designed to prevent transmission of HIV when applied vaginally or rectally. Although there are many microbicide candidates in the pipeline, animal models for evaluating their safety and efficacy are urgently needed. On the basis of comparing the non-primate small animal models and the non-human primate animal models in evaluating safety and efficacy of HIV microbicides, this review summarizes the major advantages and disadvantages of the relevant animal models. The suggested direction of research that would benefit the development of microbicides is also reviewed.

ZHU Lin, ZHANG Gao-Hong, ZHENG Yong-Tang. Application Studies of Animal Models in Evaluating Safety and Efficacy of HIV-1 Microbicides. Zoological Research, 2010, 31(1): 66-76. doi: 10.3724/SP.J.1141.2010.01066
Citation: ZHU Lin, ZHANG Gao-Hong, ZHENG Yong-Tang. Application Studies of Animal Models in Evaluating Safety and Efficacy of HIV-1 Microbicides. Zoological Research, 2010, 31(1): 66-76. doi: 10.3724/SP.J.1141.2010.01066

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