Volume 30 Issue 4
Jul.  2009
Turn off MathJax
Article Contents

SHI Xiao-dong, WANG Jin-kai, LI Yi, LUO Xiong-jian, ZHANG Wei, SU Bing. Association Study of a Schizophrenia Susceptible Gene GULP1 with Brain Volume in Chinese Populations. Zoological Research, 2009, 30(4): 377-380. doi: 10.3724/SP.J.1141.2009.04377
Citation: SHI Xiao-dong, WANG Jin-kai, LI Yi, LUO Xiong-jian, ZHANG Wei, SU Bing. Association Study of a Schizophrenia Susceptible Gene GULP1 with Brain Volume in Chinese Populations. Zoological Research, 2009, 30(4): 377-380. doi: 10.3724/SP.J.1141.2009.04377

Association Study of a Schizophrenia Susceptible Gene GULP1 with Brain Volume in Chinese Populations

doi: 10.3724/SP.J.1141.2009.04377
More Information
  • Corresponding author: SU Bing
  • Received Date: 2009-06-18
  • Rev Recd Date: 1900-01-01
  • Publish Date: 2009-08-22
  • Schizophrenia is a complex mental disease which affects about 1% of the world population. Previous studies reported that the brain volumes of the schizophrenia patients were much smaller than normal people and many schizophrenia susceptible genetic variants were associated with structural brain abnormalities in patients, which is consistent with the neurodevelopmental hypothesis of the etiology of schizophrenia. Recently, two SNPs (rs2004888 and rs452256) of GULP1 were found to be significantly associated with schizophrenia. In this study, to test whether these two SNP of GULP1 are also consistent with the neurodevelopmental hypothesis, we genotyped the two SNPs in 791 Chinese individuals and measured their brain volumes.We found that the two SNPs have no association with brain volume, suggesting that the etiology of schizophrenia is much more complicated.
  • 加载中
  • 加载中
通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索

Article Metrics

Article views(1941) PDF downloads(1699) Cited by()

Related
Proportional views

Association Study of a Schizophrenia Susceptible Gene GULP1 with Brain Volume in Chinese Populations

doi: 10.3724/SP.J.1141.2009.04377
    Corresponding author: SU Bing

Abstract: Schizophrenia is a complex mental disease which affects about 1% of the world population. Previous studies reported that the brain volumes of the schizophrenia patients were much smaller than normal people and many schizophrenia susceptible genetic variants were associated with structural brain abnormalities in patients, which is consistent with the neurodevelopmental hypothesis of the etiology of schizophrenia. Recently, two SNPs (rs2004888 and rs452256) of GULP1 were found to be significantly associated with schizophrenia. In this study, to test whether these two SNP of GULP1 are also consistent with the neurodevelopmental hypothesis, we genotyped the two SNPs in 791 Chinese individuals and measured their brain volumes.We found that the two SNPs have no association with brain volume, suggesting that the etiology of schizophrenia is much more complicated.

SHI Xiao-dong, WANG Jin-kai, LI Yi, LUO Xiong-jian, ZHANG Wei, SU Bing. Association Study of a Schizophrenia Susceptible Gene GULP1 with Brain Volume in Chinese Populations. Zoological Research, 2009, 30(4): 377-380. doi: 10.3724/SP.J.1141.2009.04377
Citation: SHI Xiao-dong, WANG Jin-kai, LI Yi, LUO Xiong-jian, ZHANG Wei, SU Bing. Association Study of a Schizophrenia Susceptible Gene GULP1 with Brain Volume in Chinese Populations. Zoological Research, 2009, 30(4): 377-380. doi: 10.3724/SP.J.1141.2009.04377

Catalog

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return