School of Basic Medical Sciences, Kunming Medical University, Kunming Yunnan 650500, China
Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province，Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming Yunnan 650223, China
Department of General Surgery, 908th Hospital of Chinese PLA Joint Logistic Support Force, Yingtan Jiangxi 335000, China
Kunming Primate Research Center of the Chinese Academy of Sciences, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming Yunnan 650223, China
Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming Yunnan 650204, China
the National Natural Science Foundation of China (31700910) and Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province(2017FB109)
Major depressive disorder (MDD), commonly known as depression, is a mental disease characterized by a core symptom of low mood. It lasts at least two weeks (Badamasi et al., 2019; Wang et al., 2019) and is frequently accompanied by low self-esteem, loss of interest in routinely enjoyable activities, low energy, and unexplained pain (Huey et al., 2018; Park et al., 2012; Post & Warden, 2018; Rice et al., 2019; Xiao et al., 2018). Approximately 2%–8% of adults with MDD commit suicide (Richards & O'Hara, 2014; Strakowski & Nelson, 2015), and around half of suicidal individuals suffer depression or other mood disorders (Bachmann, 2018).