Volume 40 Issue 3
May  2019
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Lei Shi, Bing Su. A transgenic monkey model for the study of human brain evolution. Zoological Research, 2019, 40(3): 236-238. doi: 10.24272/j.issn.2095-8137.2019.031
Citation: Lei Shi, Bing Su. A transgenic monkey model for the study of human brain evolution. Zoological Research, 2019, 40(3): 236-238. doi: 10.24272/j.issn.2095-8137.2019.031

A transgenic monkey model for the study of human brain evolution

doi: 10.24272/j.issn.2095-8137.2019.031
Funds:  This study was supported by the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB13000000), the National Natural Science Foundation of China (31730088) and the Youth Innovation Promotion Association of CAS
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  • Corresponding author: Bing Su
  • Received Date: 2019-04-04
  • Publish Date: 2019-05-18
  • Why humans have large brains with higher cognitive abilities is a question long asked by scientists. However, much remains unknown, especially the underlying genetic mechanisms. With the use of a transgenic monkey model, we showed that human-specific sequence changes of a key brain development gene (primary microcephaly1, MCPH1) could result in detectable molecular and cognitive changes resembling human neoteny, a notable characteristic developed during human evolution.
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  • [1]
    null Bufill E , Agustí J , Blesa R . 2011. Human neoteny revisited: The case of synaptic plasticity. American Journal of Human Biology, 23(6): 729–739.
    null Bustamante CD , Fledel-Alon A , Williamson S , Nielsen R , Hubisz MT , Glanowski S , Tanenbaum DM , White TJ , Sninsky JJ , Hernandez RD , Civello D , Adams MD , Cargill M , Clark AG . 2005. Natural selection on protein-coding genes in the human genome. Nature, 437(7062): 1153–1157.
    null Chen Y , Yu J , Niu Y , Qin D , Liu H , Li G , Hu Y , Wang J , Lu Y , Kang Y , Jiang Y , Wu K , Li S , Wei J , He J , Wang J , Liu X , Luo Y , Si C , Bai R , Zhang K , Liu J , Huang S , Chen Z , Wang S , Chen X , Bao X , Zhang Q , Li F , Geng R , Liang A , Shen D , Jiang T , Hu X , Ma Y , Ji W , Sun Y . E. 2017. Modeling rett syndrome using TALEN-Edited MECP2 mutant cynomolgus monkeys. Cell, 169(5): 945–955.
    null Clark AG , Glanowski S , Nielsen R , Thomas PD , Kejariwal A , Todd MA , Tanenbaum DM , Civello D , Lu F , Murphy B , Ferriera S , Wang G , Zheng X , White TJ , Sninsky JJ , Adams MD , Cargill M . 2003. Inferring nonneutral evolution from human-chimp-mouse orthologous gene trios. Science, 302(5652): 1960–1963.
    null Coors ME , Glover JJ , Juengst ET , Sikela JM . 2010. The ethics of using transgenic non-human primates to study what makes us human. Nature Reviews Genetics, 11(9): 658–662.
    null Enard W , Gehre S , Hammerschmidt K , H?lter SM , Blass T , Somel M , Brückner MK , Schreiweis C , Winter C , Sohr R , Becker L , Wiebe V , Nickel B , Giger T , Müller U , Groszer M , Adler T , Aguilar A , Bolle I , Calzada-Wack J , Dalke C , Ehrhardt N , Favor J , Fuchs H , Gailus-Durner V , Hans W , H?lzlwimmer G , Javaheri A , Kalaydjiev S , Kallnik M , Kling E , Kunder S , Mossbrugger I , Naton B , Racz I , Rathkolb B , Rozman J , Schrewe A , Busch DH , Graw J , Ivandic B , Klingenspor M , Klopstock T , Ollert M , Quintanilla-Martinez L , Schulz H , Wolf E , Wurst W , Zimmer A , Fisher SE , Morgenstern R , Arendt T , de Angelis MH , Fischer J , Schwarz J , P??bo S . 2009. A humanized version of Foxp2 affects cortico-basal ganglia circuits in mice. Cell, 137(5): 961–971.
    null Gruber R , Zhou Z , Sukchev M , Joerss T , Frappart PO , Wang ZQ . 2011. MCPH1 regulates the neuroprogenitor division mode by coupling the centrosomal cycle with mitotic entry through the Chk1-Cdc25 pathway. Nature Cell Biology, 13(11): 1325–1334.
    null Jackson AP , Eastwood H , Bell SM , Adu J , Toomes C , Carr IM , Roberts E , Hampshire DJ , Crow YJ , Mighell AJ , Karbani G , Jafri H , Rashid Y , Mueller RF , Markham AF , Woods CG . 2002. Identification of microcephalin, a protein implicated in determining the size of the human brain. American Journal of Human Genetics, 71(1): 136–142.
    null Ke Q , Li W , Lai X , Chen H , Huang L , Kang Z , Li K , Ren J , Lin X , Zheng H , Huang W , Ma Y , Xu D , Chen Z , Song X , Lin X , Zhuang M , Wang T , Zhuang F , Xi J , Mao FF , Xia H , Lahn BT , Zhou Q , Yang S , Xiang AP . 2016. TALEN-based generation of a cynomolgus monkey disease model for human microcephaly. Cell Research, 26(9): 1048–1061.
    null Liu X , Somel M , Tang L , Yan Z , Jiang X , Guo S , Yuan Y , He L , Oleksiak A , Zhang Y , Li N , Hu Y , Chen W , Qiu Z , Paabo S , Khaitovich P . 2012. Extension of cortical synaptic development distinguishes humans from chimpanzees and macaques. Genome Research, 22(4): 611–622.
    null Liu Z , Li X , Zhang JT , Cai YJ , Cheng TJ , Cheng C , Wang Y , Zhang CC , Nie YH , Chen ZF , Bian WJ , Zhang L , Xiao J , Lu B , Zhang YF , Zhang XD , Sang X , Wu JJ , Xu X , Xiong ZQ , Zhang F , Yu X , Gong N , Zhou WH , Sun Q , Qiu Z . 2016. Autism-like behaviours and germline transmission in transgenic monkeys overexpressing MeCP2. Nature, 530(7588): 98–102.
    null Luo X , Li M , Su B . 2016. Application of the genome editing tool CRISPR/Cas9 in non-human primates. Zoological Research, 37(4): 214–219.
    null Qiu P , Jiang J , Liu Z , Cai Y , Huang T , Wang Y , Liu Q , Nie Y , Liu F , Cheng J , Li Q , Tang YC , Poo MM , Sun Q , Chang HC . 2019. BMAL1 knockout macaque monkeys display reduced sleep and psychiatric disorders. National Science Review, 6(1): 87–100.
    null Shi L , Li M , Lin Q , Qi X , Su B . 2013. Functional divergence of the brain-size regulating gene MCPH1 during primate evolution and the origin of humans. BMC Biology, 11: 62.
    null Shi L , Luo X , Jiang J , Chen Y , Liu C , Hu T , Li M , Lin Q , Li Y , Huang J , Wang H , Niu Y , Shi Y , Styner M , Wang J , Lu Y , Sun X , Yu H , Ji W , Su B . 2019. Transgenic rhesus monkeys carrying the human MCPH1 gene copies show human-like neoteny of brain development. National Science Review, doi: 10.1093/nsr/nwz043.
    null Skulachev VP , Holtze S , Vyssokikh MY , Bakeeva LE, Skulachev MV , Markov AV , Hildebrandt TB , Sadovnichii VA . 2017. Neoteny, prolongation of youth: from naked mole rats to “naked apes” (humans). Physiological Reviews, 97(2):699–720.
    null Wang YQ , Su B . 2004. Molecular evolution of microcephalin, a gene determining human brain size. Human Molecular Genetics, 13(11): 1131–1137.
    null Yan G , Zhang G , Fang X , Zhang Y , Li C , Ling F , Cooper DN , Li Q , Li Y , van Gool AJ , Du H , Chen J , Chen R , Zhang P , Huang Z , Thompson JR , Meng Y , Bai Y , Wang J , Zhuo M , Wang T , Huang Y , Wei L , Li J , Wang Z , Hu H , Yang P , Le L , Stenson PD , Li B , Liu X , Ball EV , An N , Huang Q , Zhang Y , Fan W , Zhang X , Li Y , Wang W , Katze MG , Su B , Nielsen R , Yang H , Wang J , Wang X , Wang J . 2011. Genome sequencing and comparison of two nonhuman primate animal models, the cynomolgus and Chinese rhesus macaques. Nature Biotechnology, 29(11): 1019–1023.
    null Yang SH , Cheng PH , Banta H , Piotrowska-Nitsche K , Yang JJ , Cheng EC , Snyder B , Larkin K , Liu J , Orkin J , Fang ZH , Smith Y , Bachevalier J , Zola SM , Li SH , Li XJ , Chan AWS . 2008. Towards a transgenic model of Huntington's disease in a non-human primate. Nature, 453(7197): 921–924.
    null Zhang W , Wan H , Feng G , Qu J , Wang J , Jing Y , Ren R , Liu Z , Zhang L , Chen Z , Wang S , Zhao Y , Wang Z , Yuan Y , Zhou Q , Li W , Liu GH , Hu B . 2018. SIRT6 deficiency results in developmental retardation in cynomolgus monkeys. Nature, 560(7720): 661–665.
    null Zhang XL , Pang W , Hu XT , Li JL , Yao YG , Zheng YT . 2014. Experimental primates and non-human primate (NHP) models of human diseases in China: current status and progress. Zoological Research, 35(6): 447–464.
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A transgenic monkey model for the study of human brain evolution

doi: 10.24272/j.issn.2095-8137.2019.031
Funds:  This study was supported by the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB13000000), the National Natural Science Foundation of China (31730088) and the Youth Innovation Promotion Association of CAS
    Corresponding author: Bing Su

Abstract: Why humans have large brains with higher cognitive abilities is a question long asked by scientists. However, much remains unknown, especially the underlying genetic mechanisms. With the use of a transgenic monkey model, we showed that human-specific sequence changes of a key brain development gene (primary microcephaly1, MCPH1) could result in detectable molecular and cognitive changes resembling human neoteny, a notable characteristic developed during human evolution.

Lei Shi, Bing Su. A transgenic monkey model for the study of human brain evolution. Zoological Research, 2019, 40(3): 236-238. doi: 10.24272/j.issn.2095-8137.2019.031
Citation: Lei Shi, Bing Su. A transgenic monkey model for the study of human brain evolution. Zoological Research, 2019, 40(3): 236-238. doi: 10.24272/j.issn.2095-8137.2019.031
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