Overview of the improvement of the ring-stage survival assay-a novel phenotypic assay for the detection of artemisinin-resistant <em>Plasmodium falciparum</em>

Jie Zhang; Guo-Hua Feng; Chun-Yan Zou; Pin-Can Su; Huai-E Liu; Zhao-Qing Yang

doi:10.24272/j.issn.2095-8137.2017.075

Volume 38 Issue 6

Nov. 2017

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Article Navigation > Zoological Research > 2017 > 38(6): 317-320

Jie Zhang, Guo-Hua Feng, Chun-Yan Zou, Pin-Can Su, Huai-E Liu, Zhao-Qing Yang. Overview of the improvement of the ring-stage survival assay-a novel phenotypic assay for the detection of artemisinin-resistant Plasmodium falciparum. Zoological Research, 2017, 38(6): 317-320. doi: 10.24272/j.issn.2095-8137.2017.075

Citation:

Jie Zhang, Guo-Hua Feng, Chun-Yan Zou, Pin-Can Su, Huai-E Liu, Zhao-Qing Yang. Overview of the improvement of the ring-stage survival assay-a novel phenotypic assay for the detection of artemisinin-resistant Plasmodium falciparum. Zoological Research, 2017, 38(6): 317-320. doi: 10.24272/j.issn.2095-8137.2017.075

Citation:

Jie Zhang, Guo-Hua Feng, Chun-Yan Zou, Pin-Can Su, Huai-E Liu, Zhao-Qing Yang. Overview of the improvement of the ring-stage survival assay-a novel phenotypic assay for the detection of artemisinin-resistant Plasmodium falciparum. Zoological Research, 2017, 38(6): 317-320. doi: 10.24272/j.issn.2095-8137.2017.075

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Overview of the improvement of the ring-stage survival assay-a novel phenotypic assay for the detection of artemisinin-resistant Plasmodium falciparum

doi: 10.24272/j.issn.2095-8137.2017.075

1 Department of Pathogen Biology and Immunology, Kunming Medical University, Kunming Yunnan 650500, China;
2 Biomedical Engineering Research Center, Kunming Medical University, Kunming Yunnan 650500, China;
3 Guangxi Zhuang Autonomous Region People's Hospital, Nanning Guangxi 530021, China;
4 Transfusion Medicine Research Department, Yunnan Kunming Blood Center, Kunming Yunnan 650500, China;
5 Department of Infectious Diseases, The First Affiliated Hospital, Kunming Medical University, Kunming Yunnan 650032, China

Funds: This study was funded by the National Natural Science Foundation of China (31260508, U1202226) and grants of Doctor Newcomer Scholarship from Yunnan province

More Information

Corresponding author: Zhao-Qing Yang,E-mail:zhaoqing92@hotmail.com
Received Date: 2017-10-11
Rev Recd Date: 2017-11-10
Publish Date: 2017-11-18

Abstract

Abstract

Artemisinin resistance in Plasmodium falciparum threatens the remarkable efficacy of artemisinin-based combination therapies worldwide. Thus, greater insight into the resistance mechanism using monitoring tools is essential. The ring-stage survival assay is used for phenotyping artemisinin-resistance or decreased artemisinin sensitivity. Here, we review the progress of this measurement assay and explore its limitations and potential applications.
- Malaria,
- Artemisinin,
- Resistant phenotype,
- Ring-stage survival assay,
- Improvement,
- Application