Volume 38 Issue 6
Nov.  2017
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Jie Zhang, Guo-Hua Feng, Chun-Yan Zou, Pin-Can Su, Huai-E Liu, Zhao-Qing Yang. Overview of the improvement of the ring-stage survival assay-a novel phenotypic assay for the detection of artemisinin-resistant Plasmodium falciparum. Zoological Research, 2017, 38(6): 317-320. doi: 10.24272/j.issn.2095-8137.2017.075
Citation: Jie Zhang, Guo-Hua Feng, Chun-Yan Zou, Pin-Can Su, Huai-E Liu, Zhao-Qing Yang. Overview of the improvement of the ring-stage survival assay-a novel phenotypic assay for the detection of artemisinin-resistant Plasmodium falciparum. Zoological Research, 2017, 38(6): 317-320. doi: 10.24272/j.issn.2095-8137.2017.075

Overview of the improvement of the ring-stage survival assay-a novel phenotypic assay for the detection of artemisinin-resistant Plasmodium falciparum

doi: 10.24272/j.issn.2095-8137.2017.075
Funds:  This study was funded by the National Natural Science Foundation of China (31260508, U1202226) and grants of Doctor Newcomer Scholarship from Yunnan province
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  • Corresponding author: Zhao-Qing Yang,E-mail:zhaoqing92@hotmail.com
  • Received Date: 2017-10-11
  • Rev Recd Date: 2017-11-10
  • Publish Date: 2017-11-18
  • Artemisinin resistance in Plasmodium falciparum threatens the remarkable efficacy of artemisinin-based combination therapies worldwide. Thus, greater insight into the resistance mechanism using monitoring tools is essential. The ring-stage survival assay is used for phenotyping artemisinin-resistance or decreased artemisinin sensitivity. Here, we review the progress of this measurement assay and explore its limitations and potential applications.
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Overview of the improvement of the ring-stage survival assay-a novel phenotypic assay for the detection of artemisinin-resistant Plasmodium falciparum

doi: 10.24272/j.issn.2095-8137.2017.075
Funds:  This study was funded by the National Natural Science Foundation of China (31260508, U1202226) and grants of Doctor Newcomer Scholarship from Yunnan province
    Corresponding author: Zhao-Qing Yang,E-mail:zhaoqing92@hotmail.com

Abstract: Artemisinin resistance in Plasmodium falciparum threatens the remarkable efficacy of artemisinin-based combination therapies worldwide. Thus, greater insight into the resistance mechanism using monitoring tools is essential. The ring-stage survival assay is used for phenotyping artemisinin-resistance or decreased artemisinin sensitivity. Here, we review the progress of this measurement assay and explore its limitations and potential applications.

Jie Zhang, Guo-Hua Feng, Chun-Yan Zou, Pin-Can Su, Huai-E Liu, Zhao-Qing Yang. Overview of the improvement of the ring-stage survival assay-a novel phenotypic assay for the detection of artemisinin-resistant Plasmodium falciparum. Zoological Research, 2017, 38(6): 317-320. doi: 10.24272/j.issn.2095-8137.2017.075
Citation: Jie Zhang, Guo-Hua Feng, Chun-Yan Zou, Pin-Can Su, Huai-E Liu, Zhao-Qing Yang. Overview of the improvement of the ring-stage survival assay-a novel phenotypic assay for the detection of artemisinin-resistant Plasmodium falciparum. Zoological Research, 2017, 38(6): 317-320. doi: 10.24272/j.issn.2095-8137.2017.075
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