Volume 39 Issue 1
Jan.  2018
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Vinayakumar Siragam, Gary Wong, Xiang-Guo Qiu. Animal models for filovirus infections. Zoological Research, 2018, 39(1): 15-24. doi: 10.24272/j.issn.2095-8137.2017.053
Citation: Vinayakumar Siragam, Gary Wong, Xiang-Guo Qiu. Animal models for filovirus infections. Zoological Research, 2018, 39(1): 15-24. doi: 10.24272/j.issn.2095-8137.2017.053

Animal models for filovirus infections

doi: 10.24272/j.issn.2095-8137.2017.053
Funds:  This work was supported by the Public Health Agency of Canada (PHAC), partially supported by the NIH and CIHR grants to X. G. Qiu (U19 AI109762-1 and CIHR-IER-143487, respectively), and grants from the National Natural Science Foundation of China International Cooperation and Exchange Program (8161101193) and National Science and Technology Major Project (2016ZX10004222) to G. Wong
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  • Corresponding author: Xiang-Guo Qiu,E-mail:xiangguo.qiu@phac-aspc.gc.ca
  • Received Date: 2017-07-01
  • Rev Recd Date: 2017-08-26
  • Publish Date: 2018-01-18
  • The family Filoviridae, which includes the genera Marburgvirus and Ebolavirus, contains some of the most pathogenic viruses in humans and non-human primates (NHPs), causing severe hemorrhagic fevers with high fatality rates. Small animal models against filoviruses using mice, guinea pigs, hamsters, and ferrets have been developed with the goal of screening candidate vaccines and antivirals, before testing in the gold standard NHP models. In this review, we summarize the different animal models used to understand filovirus pathogenesis, and discuss the advantages and disadvantages of each model with respect to filovirus disease research.
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Animal models for filovirus infections

doi: 10.24272/j.issn.2095-8137.2017.053
Funds:  This work was supported by the Public Health Agency of Canada (PHAC), partially supported by the NIH and CIHR grants to X. G. Qiu (U19 AI109762-1 and CIHR-IER-143487, respectively), and grants from the National Natural Science Foundation of China International Cooperation and Exchange Program (8161101193) and National Science and Technology Major Project (2016ZX10004222) to G. Wong
    Corresponding author: Xiang-Guo Qiu,E-mail:xiangguo.qiu@phac-aspc.gc.ca

Abstract: The family Filoviridae, which includes the genera Marburgvirus and Ebolavirus, contains some of the most pathogenic viruses in humans and non-human primates (NHPs), causing severe hemorrhagic fevers with high fatality rates. Small animal models against filoviruses using mice, guinea pigs, hamsters, and ferrets have been developed with the goal of screening candidate vaccines and antivirals, before testing in the gold standard NHP models. In this review, we summarize the different animal models used to understand filovirus pathogenesis, and discuss the advantages and disadvantages of each model with respect to filovirus disease research.

Vinayakumar Siragam, Gary Wong, Xiang-Guo Qiu. Animal models for filovirus infections. Zoological Research, 2018, 39(1): 15-24. doi: 10.24272/j.issn.2095-8137.2017.053
Citation: Vinayakumar Siragam, Gary Wong, Xiang-Guo Qiu. Animal models for filovirus infections. Zoological Research, 2018, 39(1): 15-24. doi: 10.24272/j.issn.2095-8137.2017.053

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