Volume 39 Issue 1
Jan.  2018
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Gary Wong, Xiang-Guo Qiu. Type I interferon receptor knockout mice as models for infection of highly pathogenic viruses with outbreak potential. Zoological Research, 2018, 39(1): 3-14. doi: 10.24272/j.issn.2095-8137.2017.052
Citation: Gary Wong, Xiang-Guo Qiu. Type I interferon receptor knockout mice as models for infection of highly pathogenic viruses with outbreak potential. Zoological Research, 2018, 39(1): 3-14. doi: 10.24272/j.issn.2095-8137.2017.052

Type I interferon receptor knockout mice as models for infection of highly pathogenic viruses with outbreak potential

doi: 10.24272/j.issn.2095-8137.2017.052
Funds:  This study was supported by the National Natural Science Foundation of China International Cooperation and Exchange Program (8161101193) and the National Science and Technology Major Project (2016ZX10004222) to G. Wong
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  • Corresponding author: Gary Wong,E-mail:garyckwong@hotmail.com
  • Received Date: 2017-07-01
  • Rev Recd Date: 2017-08-26
  • Publish Date: 2018-01-18
  • Due to their inability to generate a complete immune response, mice knockout for type I interferon (IFN) receptors (Ifnar–/–) are more susceptible to viral infections, and are thus commonly used for pathogenesis studies. This mouse model has been used to study many diseases caused by highly pathogenic viruses from many families, including the Flaviviridae, Filoviridae, Arenaviridae, Bunyaviridae, Henipaviridae, and Togaviridae. In this review, we summarize the findings from these animal studies, and discuss the pros and cons of using this model versus other known methods for studying pathogenesis in animals.
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Type I interferon receptor knockout mice as models for infection of highly pathogenic viruses with outbreak potential

doi: 10.24272/j.issn.2095-8137.2017.052
Funds:  This study was supported by the National Natural Science Foundation of China International Cooperation and Exchange Program (8161101193) and the National Science and Technology Major Project (2016ZX10004222) to G. Wong
    Corresponding author: Gary Wong,E-mail:garyckwong@hotmail.com

Abstract: Due to their inability to generate a complete immune response, mice knockout for type I interferon (IFN) receptors (Ifnar–/–) are more susceptible to viral infections, and are thus commonly used for pathogenesis studies. This mouse model has been used to study many diseases caused by highly pathogenic viruses from many families, including the Flaviviridae, Filoviridae, Arenaviridae, Bunyaviridae, Henipaviridae, and Togaviridae. In this review, we summarize the findings from these animal studies, and discuss the pros and cons of using this model versus other known methods for studying pathogenesis in animals.

Gary Wong, Xiang-Guo Qiu. Type I interferon receptor knockout mice as models for infection of highly pathogenic viruses with outbreak potential. Zoological Research, 2018, 39(1): 3-14. doi: 10.24272/j.issn.2095-8137.2017.052
Citation: Gary Wong, Xiang-Guo Qiu. Type I interferon receptor knockout mice as models for infection of highly pathogenic viruses with outbreak potential. Zoological Research, 2018, 39(1): 3-14. doi: 10.24272/j.issn.2095-8137.2017.052

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