Volume 38 Issue 3
May  2017
Turn off MathJax
Article Contents
Ji Xiao, Rong Liu, Ce-Shi Chen. Tree shrew (Tupaia belangeri) as a novel laboratory disease animal model. Zoological Research, 2017, 38(3): 127-137. doi: 10.24272/j.issn.2095-8137.2017.033
Citation: Ji Xiao, Rong Liu, Ce-Shi Chen. Tree shrew (Tupaia belangeri) as a novel laboratory disease animal model. Zoological Research, 2017, 38(3): 127-137. doi: 10.24272/j.issn.2095-8137.2017.033

Tree shrew (Tupaia belangeri) as a novel laboratory disease animal model

doi: 10.24272/j.issn.2095-8137.2017.033
Funds:  This study was supported by the National Nature Science Foundation of China (81325016, U1602221, 81322038 and U1502222)
More Information
  • Corresponding author: Ce-Shi Chen,E-mail:chenc@mail.kiz.ac.cn
  • Received Date: 2017-03-14
  • Rev Recd Date: 2017-05-03
  • Publish Date: 2017-05-18
  • The tree shrew (Tupaia belangeri) is a promising laboratory animal that possesses a closer genetic relationship to primates than to rodents. In addition, advantages such as small size, easy breeding, and rapid reproduction make the tree shrew an ideal subject for the study of human disease. Numerous tree shrew disease models have been generated in biological and medical studies in recent years. Here we summarize current tree shrew disease models, including models of infectious diseases, cancers, depressive disorders, drug addiction, myopia, metabolic diseases, and immune-related diseases. With the success of tree shrew transgenic technology, this species will be increasingly used in biological and medical studies in the future.
  • loading
  • [1]
    Ábrahám H, Czéh B, Fuchs E, Seress L. 2005. Mossy cells and different subpopulations of pyramidal neurons are immunoreactive for cocaine-and amphetamine-regulated transcript peptide in the hippocampal formation of non-human primates and tree shrew (Tupaia belangeri). Neuroscience, 136(1):231-240.
    Amako Y, Tsukiyama-Kohara K, Katsume A, Hirata Y, Sekiguchi S, Tobita Y, Hayashi Y, Hishima T, Funata N, Yonekawa H, Kohara M. 2010. Pathogenesis of hepatitis C virus infection in Tupaia belangeri. Journal of Virology, 84(1):303-311.
    Brack M, Schwartz P, Heinrichs T, Schultz M, Fuchs E. 1996. Tumors of the respiratory tract observed at the German Primate Center, 1978-1994. Journal of Medical Primatology, 25(6):424-434.
    Buchholz DR. 2015. More similar than you think:frog metamorphosis as a model of human perinatal endocrinology. Developmental Biology, 408(2):188-195.
    Capecchi MR. 2005. Gene targeting in mice:functional analysis of the mammalian genome for the twenty-first century. Nature Reviews Genetics, 6(6):507-512.
    Caspi A, Sugden K, Moffitt TE, Taylor A, Craig IW, Harrington H, McClay J, Mill J, Martin J, Braithwaite A, Poulton R. 2003. Influence of life stress on depression:moderation by a polymorphism in the 5-HTT gene. Science, 301(5631):386-389.
    Chen B, Huang JL,Guo XX, Feng XT, Guo EC, Zhang SR, Chen WY, Hu YL, Zhong ZG. 2016. Study on tree shrews model of blood stasis induced by different dose of carrageen glue. World Chinese Medicine, 11(11):2219-2222. (in Chinese)
    Chen GY, Wang W, Meng SK, Zhang LC, Wang WX, Jiang ZM, Yu M, Cui QH, Li MZ. 2014. CXC chemokine CXCL12 and its receptor CXCR4 in tree shrews (Tupaia belangeri):structure, expression and function. PLoS One, 9(5):e98231.
    Chen XB, He M, Li GJ, Zhou YC, Zhao GQ, Lei YJ, Yang KY, Tian LW, Huang YC. 2015. Study of the changes on tree shrew bronchial epithelium induced by xuanwei bituminous coal dust. Chinese Journal of Lung Cancer, 18(8):469-474. (in Chinese)
    Elliot OS, Elliot MW, Lisco H. 1966. Breast cancer in a tree shrew (Tupaia glis). Nature, 211(5053):1105.
    Fan Y, Huang ZY, Cao CC, Chen CS, Chen YX, Fan DD, He J, Hou HL, Hu L, Hu XT, Jiang XT, Lai R, Lang YS, Liang B, Liao SG, Mu D, Ma YY, Niu YY, Sun XQ, Xia JQ, Xiao J, Xiong ZQ, Xu L, Yang L, Zhang Y, Zhao W, Zhao XD, Zheng YT, Zhou JM, Zhu YB, Zhang GJ, Wang J, Yao YG. 2013.
    Genome of the Chinese tree shrew. Nature Communications, 4:1426.
    Fan Y, Yu DD, Yao YG. 2014. Tree shrew database (TreeshrewDB):a genomic knowledge base for the Chinese tree shrew. Scientific Reports, 4:7145.
    Feng R, Li SQ, Li F. 2011. Toll-like receptor 4 is involved in ischemic tolerance of postconditioning in hippocampus of tree shrews to thrombotic cerebral ischemia. Brain Research, 1384:118-127.
    Fuchs E, Uno H, Flügge G. 1995. Chronic psychosocial stress induces morphological alterations in hippocampal pyramidal neurons of the tree shrew. Brain Research, 673(2):275-282.
    Fuchs E, Kramer M, Hermes B, Netter P, Hiemke C. 1996. Psychosocial stress in tree shrews:clomipramine counteracts behavioral and endocrine changes. Pharmacology Biochemistry and Behavior, 54(1):219-228.
    Fuchs E, Flügge G. 2002. Social stress in tree shrews:effects on physiology, brain function, and behavior of subordinate individuals. Pharmacology Biochemistry and Behavior, 73(1):247-258.
    Fuchs E. 2005. Social stress in tree shrews as an animal model of depression:an example of a behavioral model of a CNS disorder. CNS Spectrums, 10(3):182-190.
    Ge GZ, Xia HJ, He BL, Zhang HL, Liu WJ, Shao M, Wang CY, Xiao J, Ge F, Li FB, Li Y, Chen CS. 2016. Generation and characterization of a breast carcinoma model by PyMT overexpression in mammary epithelial cells of tree shrew, an animal close to primates in evolution. International Journal of Cancer, 138(3):642-651.
    Glebe D, Bremer CM. 2013. The molecular virology of hepatitis B virus. Seminars in Liver Disease, 33(2):103-112.
    Gravitz L. 2011. Introduction:a smouldering public-health crisis. Nature, 474(7350):S2-S4.
    Guo L, Frost MR, Siegwart JT, Jr., Norton TT. 2014. Scleral gene expression during recovery from myopia compared with expression during myopia development in tree shrew. Molecular Vision, 20:1643-1659.
    Han JB, Zhang GH, Duan Y, Ma JP, Zhang XH, Luo RH, Lü LB, Zheng YT. 2011. Sero-epidemiology of six viruses natural infection in Tupaia belangeri chinensis. Zoological Research, 32(1):11-16. (in Chinese)
    He BL, Jiao JL, Li B, Wang JT, Wang LM. 2013. Effects of Gastrodin on BDNF Expression in AD Tree Shrew. Journal of Kunming Medical University, 34(9):29-30, 37.
    He L, Frost MR, Siegwart JT, Jr., Norton TT. 2014. Gene expression signatures in tree shrew choroid during lens-induced myopia and recovery. Experimental Eye Research, 123:56-71.
    Hofmann W, Möller P, Schwaier A, Flügel RM, Zöller L, Darai G. 1981. Malignant tumours in Tupaia (tree shrew). Journal of Medical Primatology, 10(2-3):155-163.
    Huang F, Yu WH, He ZL. 2013a. Foamy virus in the tree shrew Tupaia belangeri is highly related to simian foamy virus in Macaca mulatta. AIDS Research and Human Retroviruses, 29(8):1177-1178.
    Huang XY, Li ML, Xu J, Gao YD, Wang WG, Yin AG, Li XF, Sun XM, Xia XS, Dai JJ. 2013b. Analysis of the molecular characteristics and cloning of fulllength coding sequence of interleukin-2 in tree shrews. Zoological Research, 34(2):121-126. (in Chinese)
    Ishiko S, Yoshida A, Mori F, Abiko T, Kitaya N, Kojima M, Saito K. 1997. Early ocular changes in a tree shrew model of diabetes. Nippon Ganka Gakkai Zasshi, 101(1):19-23. (in Japanese)
    Jiang HJ, Feng F, Dong ED. 2011. Model animals and animal models of human diseases. Chinese Bulletin of Life Sciences, 23(3):234-238. (in Chinese)
    Kazama I. 2016. Burn-induced subepicardial injury in frog heart:a simple model mimicking ST segment changes in ischemic heart disease. Journal of Veterinary Medical Science, 78(2):313-316.
    Khani A, Rainer G. 2012. Recognition memory in tree shrew (Tupaia belangeri) after repeated familiarization sessions. Behavioural Processes, 90(3):364-371.
    Li CH, Yan LZ, Ban WZ, Tu Q, Wu Y, Wang L, Bi R, Ji S, Ma YH, Nie WH, Lv LB, Yao YG, Zhao XD, Zheng P. 2017. Long-term propagation of tree shrew spermatogonial stem cells in culture and successful generation of transgenic offspring. Cell Research, 27(2):241-252.
    Li HY, Li JM, Li JX, Wang XX, Dai JJ, Sun XM. 2010. Insulin-resistance tree shrew model induced by high-glucose-fat-diet with dexamethasone. Laboratory Animal and Comparative Medicine, 30(3):197-200, 204. (in Chinese)
    Li JP, Liao Y, Zhang Y, Wang JJ, Wang LC, Feng K, Li QH, Liu LD. 2014. Experimental infection of tree shrews (Tupaia belangeri) with Coxsackie virus A16. Zoological Research, 35(6):485-491.
    Li LH, Li ZR, Li X, Wang EL, Lang FC, Xia YJ, Fraser NW, Gao F, Zhou JM. 2016a. Reactivation of HSV-1 following explant of tree shrew brain. Journal of Neurovirology, 22(3):293-306.
    Li LH, Li ZR, Wang EL, Yang R, Xiao Y, Han HB, Lang FC, Li X, Xia YJ, Gao F, Li QH, Fraser NW, Zhou JM. 2016b. Herpes simplex virus 1 infection of tree shrews differs from that of mice in the severity of acute infection and viral transcription in the peripheral nervous system. Journal of Virology, 90(2):790-804.
    Li QF, Ding MQ, Wang H, Mao Q, Wu CQ, Zheng H, Gu CH, Wang YM. 1995. The infection of hepatitis D virus in adult tupaia. National Medical Journal of China, 75(10):611-613, 639-641. (in Chinese)
    Li SA, Lee WH, Zhang Y. 2012. Two bacterial infection models in tree shrew for evaluating the efficacy of antimicrobial agents. Zoological Research, 33(1):1-6.
    Li SQ, Meng Q, Zhang L. 1999a. Experimental therapy of a plateletactivating factor antagonist (ginkgolide B) on photochemically induced thrombotic cerebral ischaemia in tree shrews. Clinical and Experimental Pharmacology and Physiology, 26(10):824-825.
    Li Y, Su JJ, Qin LL, Yang C, Ban KC, Yan RQ. 1999b. Synergistic effect of hepatitis B virus and aflatoxin B1 in hepatocarcinogenesis in tree shrews. Annals of the Academy of Medicine, Singapore, 28(1):67-71.
    Li Y, Dai JJ, Sun XM, Xia XS. 2011. Progress in studies on HCV receptor of Tupaia as a potential hepatitis C animal model. Zoological Research, 32(1):97-103. (in Chinese)
    Liang L, Li Y, Yang C, Cao J, Su JJ, Chen MW, Ban KC, Ou C, Duan XX, Yue HF. 2006. Preliminary study of using the artificially fed and young tree shrews as the infection model for human Hepatitis B virus. Chinese Journal of Zoonoses, 22(8):792-795. (in Chinese)
    Lin N, Xiong LL, Zhang RP, Zheng H, Wang L, Qian ZY, Zhang P, Chen ZW, Gao FB, Wang TH. 2016. Erratum to:injection of Aβ1-40 into hippocampus induced cognitive lesion associated with neuronal apoptosis and multiple gene expressions in the tree shrew. Apoptosis, 21(5):641.
    Liu HR, Wu G, Zhou B, Chen BS. 2010. Low cholesteryl ester transfer protein and phospholipid transfer protein activities are the factors making tree shrew and beijing duck resistant to atherosclerosis. Lipids in Health and Disease, 9:114.
    Magariños AM, McEwen BS, Fl ü gge G, Fuchs E. 1996. Chronic psychosocial stress causes apical dendritic atrophy of hippocampal CA3 pyramidal neurons in subordinate tree shrews. The Journal of Neuroscience, 16(10):3534-3540.
    Mali P, Aach J, Stranges PB, Esvelt KM, Moosburner M, Kosuri S, Yang LH, Church GM. 2013. CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering. Nature Biotechnology, 31(9):833-838.
    Marsh-Tootle WL, Norton TT. 1989. Refractive and structural measures of lid-suture myopia in tree shrew. Investigative Ophthalmology & Visual Science, 30(10):2245-2257.
    McBrien NA, Norton TT. 1994. Prevention of collagen crosslinking increases form-deprivation myopia in tree shrew. Experimental Eye Research, 59(4):475-486.
    McBrien NA, Cornell LM, Gentle A. 2001. Structural and ultrastructural changes to the sclera in a mammalian model of high myopia. Investigative Ophthalmology & Visual Science, 42(10):2179-2187.
    McBrien NA, Arumugam B, Metlapally S. 2012. The effect of daily transient +4 D positive lens wear on the inhibition of myopia in the tree shrew. Investigative Ophthalmology & Visual Science, 53(3):1593-1601.
    Meng BH, Liang SK, Huang S, Xian S, Shu CD. 2003. The protective effects of rosiglitazone on tree shrew's fatty liver. Chinese Journal of Digestion, 23(12):718-722. (in Chinese)
    Nair J, Topka M, Khani A, Isenschmid M, Rainer G. 2014. Tree shrews(Tupaia belangeri) exhibit novelty preference in the novel location memory task with 24-h retention periods. Frontiers in Psychology, 5:303.
    Nestler EJ, Barrot M, Dileone RJ, Eisch AJ, Gold SJ, Monteggia LM. 2002. Neurobiology of Depression. Neuron, 34(1):13-25.
    Norton TT, Amedo AO, Siegwart JT, Jr. 2006. Darkness causes myopia in visually experienced tree shrews. Investigative Ophthalmology & Visual Science, 47(11):4700-4707.
    Opitz K, Weischer ML. 1988. Volitional oral intake of nicotine in tupaias:drug-induced alterations. Drug and Alcohol Dependence, 21(2):99-104.
    Pan XH, Yang XY, Yao X, Sun XM, Zhu L, Wang JX, Pang RQ, Cai XM, Dai JJ, Ruan GP. 2014. Bone-marrow mesenchymal stem cell transplantation to treat diabetic nephropathy in tree shrews. Cell Biochemistry & Function, 32(5):453-463.
    Pang QF, Wu XB, Xu AY, Wang ZM, Wang GX, Zhu BY, Zhang XS. 1981. Hepatitis b virus (HBV) infection in tree shrews experimental research(abstract). Journal of Medical Research, (9):11-12. (in Chinese)
    Park US, Su JJ, Ban KC, Qin LL, Lee EH, Lee YI. 2000. Mutations in the p53 tumor suppressor gene in tree shrew hepatocellular carcinoma associated with hepatitis B virus infection and intake of aflatoxin B1. Gene, 251(1):73-80.
    Pawlik M, Fuchs E, Walker LC, Levy E. 1999. Primate-like amyloid-β sequence but no cerebral amyloidosis in aged tree shrews. Neurobiology of Aging, 20(1):47-51.
    Qian BC, Shi H, Lü YP. 2007. Development of model of nonalcoholic fatty liver disease and steatohepatitis. Chinese Journal of Comparative Medicine, 17(7):426-430. (in Chinese)
    Rabb GB, Getty RE, Williamson WM, Lombard LS. 1966. Spontaneous diabetes mellitus in tree shrews, Urogale everetti. Diabetes, 15(5):327-330.
    Ranc V, Petruzziello F, Kretz R, Argandoña EG, Zhang XZ, Rainer G. 2012. Broad characterization of endogenous peptides in the tree shrew visual system. Journal of Proteomics, 75(9):2526-2535.
    Rao MS, Reddy JK. 1980. Carcinogenicity of 2,2'-dihydroxy-di-npropylnitrosamine in the tree shrew (Tupaia glis):light and electron microscopic features of pulmonary adenomas. Journal of the National Cancer Institute, 65(4):835-840.
    Raphael SW, Zhang YD, Chen YX. 2012. Hepatocellular carcinoma:focus on different aspects of management. ISRN Oncology, 2012:421673.
    Reddy JK, Svoboda DJ, Rao MS. 1976. Induction of liver tumors by aflatoxin B1 in the tree shrew (Tupaia glis), a nonhuman primate. Cancer Research, 36(1):151-160.
    Ruan GP, Yao X, Liu JF, He J, Li ZA, Yang JY, Pang RQ, Pan XH. 2016. Establishing a tree shrew model of systemic lupus erythematosus and cell transplantation treatment. Stem Cell Research & Therapy, 7(1):121.
    Ruan P, Yang C, Su JJ, Cao J, Ou C, Luo CP, Tang YP, Wang Q, Yang F, Shi JL, Lu XX, Zhu LQ, Qin H, Sun W, Lao YZ, Li Y. 2013. Histopathological changes in the liver of tree shrew (Tupaia belangeri chinensis) persistently infected with hepatitis B virus. Virology Journal, 10(1):333.
    Schmelting B, Corbach-Söhle S, Kohlhause S, Schlumbohm C, Flügge G, Fuchs E. 2014. Agomelatine in the tree shrew model of depression:effects on stress-induced nocturnal hyperthermia and hormonal status. European Neuropsychopharmacology, 24(3):437-447.
    Schwaier A. 1979. Tupaias (tree shrews)-a new animal model for gallstone research. Research in Experimental Medicine, 176(1):15-24.
    Shao M, Ge GZ, Liu WJ, Xiao J, Xia HJ, Fan Y, Zhao F, He BL, Chen CS. 2017. Characterization and phylogenetic analysis of Kruppel-like transcription factor (KLF) gene family in tree shrews (Tupaia belangeri chinensis). Oncotarget, 7(10):16325-16339.
    Shaw JE, Sicree RA, Zimmet PZ. 2010. Global estimates of the prevalence of diabetes for 2010 and 2030. Diabetes Research and Clinical Practice, 87(1):4-14.
    Siegwart JT, Jr., Norton TT. 2002. The time course of changes in mRNA levels in tree shrew sclera during induced myopia and recovery. Investigative Ophthalmology & Visual Science, 43(7):2067-2075.
    Siegwart JT, Jr., Norton TT. 2010. Binocular lens treatment in tree shrews:effect of age and comparison of plus lens wear with recovery from minus lens-induced myopia. Experimental Eye Research, 91(5):660-669.
    Srinivasan K, Ramarao P. 2007. Animal models in type 2 diabetes research:an overview. The Indian Journal of Medical Research, 125(3):451-472.
    Su JJ. 1987. Experimental infection of human hepatitis B virus (HBV) in adult tree shrews. Chinese Journal of Pathology, 16(2):103-106, 22. (in Chinese)
    Su JJ, Li Y, Ban KC, Qin LL, Wang HY, Yang C, Ou C, Duan XX, Lee YY, Yan RQ. 2003. Alteration of the p53 gene during tree shrews' hepatocarcinogenesis. Hepatobiliary & Pancreatic Diseases International, 2(4):612-616.
    Su JJ, Ban KC, Li Y, Qin LL, Wang HY, Yang C, Ou C, Duan XX, Lee YL, Yang RQ. 2004. Alteration of p53 and p21 during hepatocarcinogenesis in tree shrews. World Journal Of Gastroenterology, 10(24):3559-3563.
    Sun YM, Yang JZ, Sun HY, Ma YY, Wang JH. 2012. Establishment of tree shrew chronic morphine dependent model. Zoological Research, 33(1):14-18.
    Thun MJ, Delancey JO, Center MM, Jemal A, Ward EM. 2010. The global burden of cancer:priorities for prevention. Carcinogenesis, 31(1):100-110.
    Tong YH, Zhou X, Zhao XD. 2014. Tree shrew glioma tumor model. In:Zheng YT, Yao YG, Xu L. Basic Biology and Disease Models of Tree Shrews. Kunming:Yunnan Science and Technology Press, 427-437. (in Chinese)
    Tong YH, Hao JJ, Tu Q, Yu HL, Yan LZ, Li Y, Lv LB, Wang F, Iavarone A, Zhao XD. 2017. A tree shrew glioblastoma model recapitulates features of human glioblastoma. Oncotarget, 8(11):17897-17907.
    Tong YM, Zhu YZ, Xia XS, Liu Y, Feng Y, Hua X, Chen ZH, Ding H, Gao L, Wang YZ, Feitelson MA, Zhao P, Qi ZT. 2011. Tupaia CD81, SR-BI, claudin-1, and occludin support hepatitis C virus infection. Journal of Virology, 85(6):2793-2802.
    Torre LA, Siegel RL, Jemal A. 2016. Lung Cancer Statistics. Advances in Experimental Medicine and Biology, 893:1-19.
    Van Kampen M, Schmitt U, Hiemke C, Fuchs E. 2000. Diazepam has no beneficial effects on stress-induced behavioural and endocrine changes in male tree shrews. Pharmacology Biochemistry and Behavior, 65(3):539-546.
    Van Kampen M, Kramer M, Hiemke C, Flügge G, Fuchs E. 2002. The chronic psychosocial stress paradigm in male tree shrews:evaluation of a novel animal model for depressive disorders. Stress, 5(1):37-46.
    Veit J, Bhattacharyya A, Kretz R, Rainer G. 2011. Neural response dynamics of spiking and local field potential activity depend on CRT monitor refresh rate in the tree shrew primary visual cortex. Journal of Neurophysiology, 106(5):2303-2313.
    Veit J, Bhattacharyya A, Kretz R, Rainer G. 2014. On the relation between receptive field structure and stimulus selectivity in the tree shrew primary visual cortex. Cerebral Cortex, 24(10):2761-2771.
    Walter E, Keist R, Niederöst B, Pult I, Blum HE. 1996. Hepatitis B virus infection of tupaia hepatocytes in vitro and in vivo. Hepatology, 24(1):1-5.
    Wang J, Zhou QX, Tian M, Yang YX, Xu L. 2011. Tree shrew models:a chronic social defeat model of depression and a one-trial captive conditioning model of learning and memory. Zoological Research, 32(1):24-30.
    Wang J, Chai AP, Zhou QX, Lv LB, Wang LP, Yang YX, Xu L. 2013a. Chronic clomipramine treatment reverses core symptom of depression in subordinate tree shrews. PLoS One, 8(12):e80980.
    Wang Q, Schwarzenberger P, Yang F, Zhang JJ, Su JJ, Yang C, Cao J, Ou C, Liang L, Shi JL, Yang F, Wang DP, Wang J, Wang XJ, Ruan P, Li Y. 2012a. Experimental chronic hepatitis B infection of neonatal tree shrews(Tupaia belangeri chinensis):a model to study molecular causes for susceptibility and disease progression to chronic hepatitis in humans.
    Virology Journal, 9(1):170.
    Wang SX, Shan D, Dai JK, Niu HC, Ma YY, Lin FC, Lei H. 2013b. Anatomical MRI templates of tree shrew brain for volumetric analysis and voxel-based morphometry. Journal of Neuroscience Methods, 220(1):9-17.
    Wang WG, Huang XY, Xu J, Sun XM, Dai JJ, Li QH. 2012b. Experimental studies on infant Tupaia belangeri chineses with EV71 infection. Zoological Research, 33(1):7-13. (in Chinese)
    Wang YX. 1987. Taxonomic research on Burma-Chinese tree shrew, Tupaia belangeri (Wagner), from Southern China. Zoological Research, 8(3):213-230. (in Chinese)
    Wiens F, Zitzmann A, Lachance MA, Yegles M, Pragst F, Wurst FM, Von Holst D, Guan SL, Spanagel R. 2008. Chronic intake of fermented floral nectar by wild treeshrews. Proceedings of the National Academy of Sciences of the United States of America, 105(30):10426-10431.
    Wu XY, Li YH, Chang Q, Zhang LQ, Liao SS, Liang B. 2013. Streptozotocin induction of type 2 diabetes in tree shrew. Zoological Research, 34(2):108-115. (in Chinese)
    Xia HJ, Wang CY, Zhang HL, He BL, Jiao JL, Chen CS. 2012. Characterization of spontaneous breast tumor in tree shrews (Tupaia belangeri chinenesis). Zoological Research, 33(1):55-59.
    Xia HJ, He BL, Wang CY, Zhang HL, Ge GZ, Zhang YX, Lv LB, Jiao JL, Chen CS. 2014. PTEN/PIK3CA genes are frequently mutated in spontaneous and medroxyprogesterone acetate-accelerated 7,12-dimethylbenz(a)anthracene-induced mammary tumours of tree shrews. European Journal of Cancer, 50(18):3230-3242.
    Xian S, Huang S, Su JJ, Qin YF, Ou C, Luo ZJ, Wei MY. 2000. A study on experimental diabetes animal models in tree shrews induced by streptozotocin. Journal of Guangxi Medical University, 17(6):945-948. (in Chinese)
    Xie ZC, Riezu-Boj JI, Lasarte JJ, Guillen J, Su JH, Civeira MP, Prieto J. 1998. Transmission of hepatitis C virus infection to tree shrews. Virology, 244(2):513-520.
    Xing HJ, Jia K, He J, Shi CZ, Fang MX, Song LL, Zhang P, Zhao Y, Fu JN, Li SJ. 2015. Establishment of the tree shrew as an alcohol-induced Fatty liver model for the study of alcoholic liver diseases. PLoS One, 10(6):e0128253.
    Xu L. 2011. Animal models of human diseases. Zoological Research, 32(1):1-3. (in Chinese)
    Xu L, Zhang Y, Liang B, Lü LB, Chen CS, Chen YB, Zhou JM, Yao YG. 2013. Tree shrews under the spot light:emerging model of human diseases. Zoological Research, 34(2):59-69.
    Xu L, Yu DD, Fan Y, Peng L, Wu Y, Yao YG. 2016. Loss of RIG-I leads to a functional replacement with MDA5 in the Chinese tree shrew. Proceedings of the National Academy of Sciences of the United States of America, 113(39):10950-10955.
    Xu XS, Hou XM, Wang W, Hao PQ, Zhu KL, Yan HK, Huang QS, Yang SH. 2015. DMBA induced breast tumors in tree shrews (Tupaia Belangeri Chinese). Progress in Modern Biomedicine, 15(2):228-232.
    Xu Y, Köck J, Lu YP, Yang DL, Lu MJ, Zhao XP. 2011. Suppression of hepatitis B virus replication in Tupaia hepatocytes by tumor necrosis factor alpha of Tupaia belangeri. Comparative Immunology, Microbiology and Infectious Diseases, 34(4):361-368.
    Xue LX, Zhang FZ, Sun RJ, Dong ED. 2014. Research status and perspective of disease animal models in China. Scientia Sinica Vitae, 44(9):851-860. Yamashita A, Fuchs E, Taira M, Yamamoto T, Hayashi M. 2012. Somatostatin-immunoreactive senile plaque-like structures in the frontal cortex and nucleus accumbens of aged tree shrews and Japanese macaques. Journal of Medical Primatology, 41(3):147-157.
    Yan H, Zhong GC, Xu GW, He WH, Jing ZY, Gao ZC, Huang Y, Qi YH, Peng B, Wang HM, Fu LR, Song M, Chen P, Gao WQ, Ren BJ, Sun YY, Cai T, Feng XF, Sui JH, Li WH. 2012. Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus. eLife, 1:e00049.
    Yan RQ, Su JJ, Huang DR, Gan YC, Yang C, Huang GH. 1996. Human hepatitis B virus and hepatocellular carcinoma. Ⅱ. Experimental induction of hepatocellular carcinoma in tree shrews exposed to hepatitis B virus and aflatoxin B1. Journal of Cancer Research and Clinical Oncology, 122(5):289-295.
    Yang C, Ruan P, Ou C, Su JJ, Cao J, Luo CP, Tang YP, Wang Q, Qin H, Sun W, Li Y. 2015. Chronic hepatitis B virus infection and occurrence of hepatocellular carcinoma in tree shrews (Tupaia belangeri chinensis). Virology Journal, 12:26.
    Yang F, Cao J, Zhang JJ, Wang Q, Su JJ, Yang C, Ou C, Shi JL, Wang DP, Li Y. 2009. Long-term observation of hepatitis B virus (HBV) replication in new-born tree shrews inoculated with HBV. Chinese Journal of Hepatology, 17(8):580-584.
    Yang ZF, Zhao J, Zhu YT, Wang YT, Liu R, Zhao SS, Li RF, Yang CG, Li JQ, Zhong NS. 2013. The tree shrew provides a useful alternative model for the study of influenza H1N1 virus. Virology Journal, 10(1):111.
    Ye LH, He M, Huang YC, Zhao GQ, Lei YJ, Zhou YC, Chen XB. 2016. Tree shrew as a new animal model for the study of lung cancer. Oncology Letters, 11(3):2091-2095.
    Yu WH, Yang CC, Bi YH, Long FY, Li YL, Wang J, Huang F. 2016. Characterization of hepatitis E virus infection in tree shrew (Tupaia belangeri chinensis). BMC Infectious Diseases, 16(1):80.
    Zhan LJ, Ding HR, Lin SZ, Tang J, Deng W, Xu YF, Xu YH, Qin C. 2014. Experimental Mycobacterium tuberculosis infection in the Chinese tree shrew. FEMS Microbiology Letters 360(1):23-32.
    Zhang LQ, Zhang ZG, Li YH, Liao SS, Wu XY, Chang Q, Liang B. 2015. Cholesterol induces lipoprotein lipase expression in a tree shrew (Tupaia belangeri chinensis) model of non-alcoholic fatty liver disease. Scientific Reports, 5:15970.
    Zhang LQ, Wu XY, Liao SS, Li YH, Zhang ZG, Chang Q, Xiao RY, Liang B. 2016. Tree shrew (Tupaia belangeri chinensis), a novel non-obese animal model of non-alcoholic fatty liver disease. Biology Open, 5(10):1545-1552.
    Zhang XH, Dai ZX, Zhang GH, Han JB, Zheng YT. 2013. Molecular characterization, balancing selection, and genomic organization of the tree shrew (Tupaia belangeri) MHC class I gene. Gene, 522(2):147-155.
    Zhao F, Guo XL, Wang YJ, Liu J, Lee WH, Zhang Y. 2014. Drug target mining and analysis of the Chinese tree shrew for pharmacological testing. PLoS One, 9(8):e104191.
    Zhao XP, Tang ZY, Klumpp B, Wolff-Vorbeck G, Barth H, Levy S, Von Weizsäcker F, Blum HE, Baumert TF. 2002. Primary hepatocytes of Tupaia belangeri as a potential model for hepatitis C virus infection. The Journal of Clinical Investigation, 109(2):221-232.
    Zhong GC, Yan H, Wang HM, He WH, Jing ZY, Qi YH, Fu LR, Gao ZC, Huang Y, Xu GW, Feng XF, Sui JH, Li WH. 2013. Sodium taurocholate cotransporting polypeptide mediates woolly monkey hepatitis B virus infection of Tupaia hepatocytes. Journal of Virology, 87(12):7176-7184.
  • Relative Articles

    [1] Ling Xu, Dan-Dan Yu, Yu-Hua Ma, Yu-Lin Yao, Rong-Hua Luo, Xiao-Li Feng, Hou-Rong Cai, Jian-Bao Han, Xue-Hui Wang, Ming-Hua Li, Chang-Wen Ke, Yong-Tang Zheng, Yong-Gang Yao. COVID-19-like symptoms observed in Chinese tree shrews infected with SARS-CoV-2. Zoological Research, 2020, 41(5): 517-526.  doi: 10.24272/j.issn.2095-8137.2020.053
    [2] Ting Song, Jun Zhou. Primary cilia in corneal development and disease. Zoological Research, 2020, 41(5): 495-502.  doi: 10.24272/j.issn.2095-8137.2020.109
    [3] Gary Wong, Xiang-Guo Qiu. Type I interferon receptor knockout mice as models for infection of highly pathogenic viruses with outbreak potential. Zoological Research, 2018, 39(1): 3-14.  doi: 10.24272/j.issn.2095-8137.2017.052
    [4] Wei-Na Guo, Bin Zhu, Ling Ai, Dong-Liang Yang, Bao-Ju Wang.  Animal models for the study of hepatitis B virus infection. Zoological Research, 2018, 39(1): 25-31.  doi: 10.24272/j.issn.2095-8137.2018.013
    [5] Gary Wong, Wen-Guang Cao, Shi-Hua He, Zi-Rui Zhang, Wen-Jun Zhu, Estella Moffat, Hideki Ebihara, Carissa Embury-Hyatt, Xiang-Guo Qiu. Development and characterization of a guinea pig model for Marburg virus. Zoological Research, 2018, 39(1): 32-41.  doi: 10.24272/j.issn.2095-8137.2017.054
    [6] Yong-Gang Yao. Creating animal models, why not use the Chinese tree shrew (Tupaia belangeri chinensis)?. Zoological Research, 2017, 38(3): 118-126.  doi: 10.24272/j.issn.2095-8137.2017.032
    [7] Ming GUO, Wen-Zhe HO. Animal models to study Mycobacterium tuberculosis and HIV co-infection. Zoological Research, 2014, 35(3): 163-169.  doi: 10.11813/j.issn.0254-5853.2014.3.163
    [8] GUO Li-Yun, WEI Jing-Kuan, YANG Shang-Chuan, WANG Zheng-Bo. Glaucoma model for stem cell transplantation research in New Zealand white rabbits. Zoological Research, 2012, (2): 225-230.  doi: 10.3724/SP.J.1141.2012.02225
    [9] ZHU Hui-Fang, ZHANG Yuan-Xu, ZHAO Xu-Dong. Animal models of human glioma: the progress of application and investigation. Zoological Research, 2012, 33(3): 337-342.  doi: 10.3724/SP.J.1141.2012.03337
    [10] WANG Wen-Guang, HUANG Xiao-Yan, XU Juan, SUN Xiao-Mei, DAI Jie-Jie, LI Qi-Han. Experimental studies on infant Tupaia belangeri chineses with EV71 infection. Zoological Research, 2012, 33(1): 7-13.  doi: 10.3724/SP.J.1141.2012.01007
    [11] CAO Guang, NIE Wen-Hui, LIU Feng-Liang, KUANG Yi-Qun, WANG Jin-Huan, SU Wei-Ting, ZH Y. Identification of the TRIM5/TRIMCyp heterozygous genotype in Macaca assamensis. Zoological Research, 2011, 32(1): 40-49.  doi: 10.3724/SP.J.1141.2011.01040
    [12] SHEN Pei-Qing, ZHENG Hong, LIU Ru-Wen, CHEN Li-Ling, LI Bo, HE Bao-Li, LI Jin-Tao, BE. Progress and prospect in research on laboratory tree shrew in China. Zoological Research, 2011, 32(1): 109-114.  doi: 10.3724/SP.J.1141.2011.01109
    [13] LI Yuan, SU Jian-Jia, YANG Chun, CAO Ji, OU Chao, LIANG Liang, YANG Fang, WANG. Progress on establishment of tree shrew(Tupaia) chronic infection with HBV in vivo. Zoological Research, 2011, 32(1): 104-108.  doi: 10.3724/SP.J.1141.2011.01104
    [14] MA Yu-Zhen, REN Yu, ZHOU Xue-Yuan, LIU Dong-jun, XU Ri-Gan. Production of transgenic embryos through nuclear transfer using ovine fetal fibroblasts transferred with foreign genes. Zoological Research, 2011, 32(6): 617-623.  doi: 10.3724/SP.J.1141.2011.06617
    [15] LI Yao, DAI Jie-Jie, SUN Xiao-Mei, XIA Xue-Shan. Progress in studies on HCV receptor of Tupaia as a potential hepatitis C animal model. Zoological Research, 2011, 32(1): 97-103.  doi: 10.3724/SP.J.1141.2011.01097
    [16] ZHU Lin, ZHANG Gao-Hong, ZHENG Yong-Tang. Application Studies of Animal Models in Evaluating Safety and Efficacy of HIV-1 Microbicides. Zoological Research, 2010, 31(1): 66-76.  doi: 10.3724/SP.J.1141.2010.01066
    [17] ZHANG Gao-hong, CHEN Ya-li, TANG Hong, ZHENG Yong-tang. Humanized SCID Mouse:A Small Animal Model for HIV Research. Zoological Research, 2004, 25(4): 356-362.
    [18] GUO Ren, CHEN Shu-fan, LUO Qi-sheng, WANG Qing-ling, YI Hong-kun, ZHAN Qiong-fen. Transgenic Mice as A Model For Neurovirulence Test of Live Poliomyelitis Vaccines. Zoological Research, 1999, 20(4): 241-246.
    [19] HUANG Hai, BEN Kun-long, ZHENG Yong-tang. Current Status in Research on Animal Models For human Aquired Immunodeficiency Syndrome. Zoological Research, 1997, 18(1): 121-128.
    [20] ZHANG Da-zhong CHEN Su-qing CHEN Jian-xuan et al.HE Guang-xin FENG Wen-he. Relations Between Disease and Trace Elements in Giant Panda Hair. Zoological Research, 1991, 12(1): 73-78.
  • 加载中


    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Article Metrics

    Article views (1044) PDF downloads(1306) Cited by()
    Proportional views


    DownLoad:  Full-Size Img  PowerPoint