Volume 38 Issue 1
Jan.  2017
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Jian-Rong Yang. Does mRNA structure contain genetic information for regulating co-translational protein folding?. Zoological Research, 2017, 38(1): 36-43. doi: 10.13918/j.issn.2095-8137.2017.004
Citation: Jian-Rong Yang. Does mRNA structure contain genetic information for regulating co-translational protein folding?. Zoological Research, 2017, 38(1): 36-43. doi: 10.13918/j.issn.2095-8137.2017.004

Does mRNA structure contain genetic information for regulating co-translational protein folding?

doi: 10.13918/j.issn.2095-8137.2017.004
Funds:  This study was supported by the start-up grant from "Top 100 Talents Program" of Sun Yat-sen University to JRY (50000-31131114) and General Program of National Natural Science Foundation of China to JRY (31671320)
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  • Corresponding author: Jian-Rong Yang,E-mail:yangjr27@mail.sysu.edu.cn
  • Received Date: 2016-12-01
  • Rev Recd Date: 2017-01-04
  • Publish Date: 2017-01-18
  • Currently many facets of genetic information are ill-defined. In particular, how protein folding is genetically regulated has been a long-standing issue for genetics and protein biology. And a generic mechanistic model with supports of genomic data is still lacking. Recent technological advances have enabled much needed genome-wide experiments. While putting the effect of codon optimality on debate, these studies have supplied mounting evidence suggesting a role of mRNA structure in the regulation of protein folding by modulating translational elongation rate. In conjunctions with previous theories, this mechanistic model of protein folding guided by mRNA structure shall expand our understandings of genetic information and offer new insights into various biomedical puzzles.
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Does mRNA structure contain genetic information for regulating co-translational protein folding?

doi: 10.13918/j.issn.2095-8137.2017.004
Funds:  This study was supported by the start-up grant from "Top 100 Talents Program" of Sun Yat-sen University to JRY (50000-31131114) and General Program of National Natural Science Foundation of China to JRY (31671320)
    Corresponding author: Jian-Rong Yang,E-mail:yangjr27@mail.sysu.edu.cn

Abstract: Currently many facets of genetic information are ill-defined. In particular, how protein folding is genetically regulated has been a long-standing issue for genetics and protein biology. And a generic mechanistic model with supports of genomic data is still lacking. Recent technological advances have enabled much needed genome-wide experiments. While putting the effect of codon optimality on debate, these studies have supplied mounting evidence suggesting a role of mRNA structure in the regulation of protein folding by modulating translational elongation rate. In conjunctions with previous theories, this mechanistic model of protein folding guided by mRNA structure shall expand our understandings of genetic information and offer new insights into various biomedical puzzles.

Jian-Rong Yang. Does mRNA structure contain genetic information for regulating co-translational protein folding?. Zoological Research, 2017, 38(1): 36-43. doi: 10.13918/j.issn.2095-8137.2017.004
Citation: Jian-Rong Yang. Does mRNA structure contain genetic information for regulating co-translational protein folding?. Zoological Research, 2017, 38(1): 36-43. doi: 10.13918/j.issn.2095-8137.2017.004

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