Volume 35 Issue 6
Nov.  2014
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Hui-Hua LIU, Cai-Fei HUANG, Xin WANG. Acoustic signal characteristic detection by neurons in ventral nucleus of the lateral lemniscus in mice. Zoological Research, 2014, 35(6): 500-509. doi: 10.13918/j.issn.2095-8137.2014.6.500
Citation: Hui-Hua LIU, Cai-Fei HUANG, Xin WANG. Acoustic signal characteristic detection by neurons in ventral nucleus of the lateral lemniscus in mice. Zoological Research, 2014, 35(6): 500-509. doi: 10.13918/j.issn.2095-8137.2014.6.500

Acoustic signal characteristic detection by neurons in ventral nucleus of the lateral lemniscus in mice

doi: 10.13918/j.issn.2095-8137.2014.6.500
Funds:  This study was supported by the National Natural Science Foundation of China (31000493) and the Central China Normal University Independent Scientific Research Project Fund for Youth Scholars (11A01025)
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  • Corresponding author: Xin WANG
  • Received Date: 2014-03-15
  • Rev Recd Date: 2014-06-01
  • Publish Date: 2014-11-08
  • Under free field conditions, we used single unit extracellular recording to study the detection of acoustic signals by neurons in the ventral nucleus of the lateral lemniscus (VNLL) in Kunming mouse (Mus musculus). The results indicate two types of firing patterns in VNLL neurons: onset and sustained. The first spike latency (FSL) of onset neurons was shorter than that of sustained neurons. With increasing sound intensity, the FSL of onset neurons remained stable and that of sustained neurons was shortened, indicating that onset neurons are characterized by precise timing. By comparing the values of Q10 and Q30 of the frequency tuning curve, no differences between onset and sustained neurons were found, suggesting that firing pattern and frequency tuning are not correlated. Among the three types of rate-intensity function (RIF) found in VNLL neurons, the proportion of monotonic RIF is the largest, followed by saturated RIF, and non-monotonic RIF. The dynamic range (DR) in onset neurons was shorter than in sustained neurons, indicating different capabilities in intensity tuning of different firing patterns and that these differences are correlated with the type of RIF. Our results also show that the best frequency of VNLL neurons was negatively correlated with depth, supporting the view point that the VNLL has frequency topologic organization.
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Acoustic signal characteristic detection by neurons in ventral nucleus of the lateral lemniscus in mice

doi: 10.13918/j.issn.2095-8137.2014.6.500
Funds:  This study was supported by the National Natural Science Foundation of China (31000493) and the Central China Normal University Independent Scientific Research Project Fund for Youth Scholars (11A01025)
    Corresponding author: Xin WANG

Abstract: Under free field conditions, we used single unit extracellular recording to study the detection of acoustic signals by neurons in the ventral nucleus of the lateral lemniscus (VNLL) in Kunming mouse (Mus musculus). The results indicate two types of firing patterns in VNLL neurons: onset and sustained. The first spike latency (FSL) of onset neurons was shorter than that of sustained neurons. With increasing sound intensity, the FSL of onset neurons remained stable and that of sustained neurons was shortened, indicating that onset neurons are characterized by precise timing. By comparing the values of Q10 and Q30 of the frequency tuning curve, no differences between onset and sustained neurons were found, suggesting that firing pattern and frequency tuning are not correlated. Among the three types of rate-intensity function (RIF) found in VNLL neurons, the proportion of monotonic RIF is the largest, followed by saturated RIF, and non-monotonic RIF. The dynamic range (DR) in onset neurons was shorter than in sustained neurons, indicating different capabilities in intensity tuning of different firing patterns and that these differences are correlated with the type of RIF. Our results also show that the best frequency of VNLL neurons was negatively correlated with depth, supporting the view point that the VNLL has frequency topologic organization.

Hui-Hua LIU, Cai-Fei HUANG, Xin WANG. Acoustic signal characteristic detection by neurons in ventral nucleus of the lateral lemniscus in mice. Zoological Research, 2014, 35(6): 500-509. doi: 10.13918/j.issn.2095-8137.2014.6.500
Citation: Hui-Hua LIU, Cai-Fei HUANG, Xin WANG. Acoustic signal characteristic detection by neurons in ventral nucleus of the lateral lemniscus in mice. Zoological Research, 2014, 35(6): 500-509. doi: 10.13918/j.issn.2095-8137.2014.6.500
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