Volume 35 Issue 6
Nov.  2014
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Article Contents
Jian-Ping LI, Yun LIAO, Ying ZHANG, Jing-Jing WANG, Li-Chun WANG, Kai FENG, Qi-Han LI, Long-Ding LIU. Experimental infection of tree shrews(Tupaia belangeri) with Coxsackie virus A16. Zoological Research, 2014, 35(6): 485-491. doi: 10.13918/j.issn.2095-8137.2014.6.485
Citation: Jian-Ping LI, Yun LIAO, Ying ZHANG, Jing-Jing WANG, Li-Chun WANG, Kai FENG, Qi-Han LI, Long-Ding LIU. Experimental infection of tree shrews(Tupaia belangeri) with Coxsackie virus A16. Zoological Research, 2014, 35(6): 485-491. doi: 10.13918/j.issn.2095-8137.2014.6.485

Experimental infection of tree shrews(Tupaia belangeri) with Coxsackie virus A16

doi: 10.13918/j.issn.2095-8137.2014.6.485
Funds:  This work was supported by the National High-Tech R&D Program (2014ZX09102042), the National Natural Science Foundation of China (81373142) and the Natural Science Foundation of Yunnan Province (2012ZA009)
More Information
  • Corresponding author: Qi-Han LI, Long-Ding LIU
  • Received Date: 2014-04-11
  • Rev Recd Date: 2014-05-20
  • Publish Date: 2014-11-08
  • Coxsackie virus A16 (CA16) is commonly recognized as one of the main human pathogens of hand-foot-mouth disease (HFMD). The clinical manifestations of HFMD include vesicles of hand, foot and mouth in young children and severe inflammatory CNS lesions. In this study, experimentally CA16 infected tree shrews(Tupaia belangeri) were used to investigate CA16 pathogenesis. The results showed that both the body temperature and the percentages of blood neutrophilic granulocytes / monocytes of CA16 infected tree shrews increased at 4-7 days post infection. Dynamic distributions of CA16 in different tissues and stools were found at different infection stages. Moreover, the pathological changes in CNS and other organs were also observed. These findings indicate that tree shrews can be used as a viable animal model to study CA16 infection.
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