Volume 35 Issue 6
Nov.  2014
Turn off MathJax
Article Contents
Xiao-Liang ZHANG, Wei PANG, Xin-Tian HU, Jia-Li LI, Yong-Gang YAO, Yong-Tang ZHENG. Experimental primates and non-human primate (NHP) models of human diseases in China: current status and progress. Zoological Research, 2014, 35(6): 447-464. doi: 10.13918/j.issn.2095-8137.2014.6.447
Citation: Xiao-Liang ZHANG, Wei PANG, Xin-Tian HU, Jia-Li LI, Yong-Gang YAO, Yong-Tang ZHENG. Experimental primates and non-human primate (NHP) models of human diseases in China: current status and progress. Zoological Research, 2014, 35(6): 447-464. doi: 10.13918/j.issn.2095-8137.2014.6.447

Experimental primates and non-human primate (NHP) models of human diseases in China: current status and progress

doi: 10.13918/j.issn.2095-8137.2014.6.447
Funds:  This work was supported by the National Natural Science Foundation of China (81172876, 81273251, U1202228, 81471620); the National Special Science Research Program of China (2012CBA01305); the National Science and Technology Major Project (2013ZX10001-002, 2012ZX10001-007) and the Knowledge Innovation Program of CAS (KSCX2-EW-R-13, KJZD-EW-L10-02)
More Information
  • Corresponding author: Yong-Tang ZHENG
  • Received Date: 2014-06-11
  • Rev Recd Date: 2014-08-15
  • Publish Date: 2014-11-08
  • Non-human primates (NHPs) are phylogenetically close to humans, with many similarities in terms of physiology, anatomy, immunology, as well as neurology, all of which make them excellent experimental models for biomedical research. Compared with developed countries in America and Europe, China has relatively rich primate resources and has continually aimed to develop NHPs resources. Currently, China is a leading producer and a major supplier of NHPs on the international market. However, there are some deficiencies in feeding and management that have hampered China's growth in NHP research and materials. Nonetheless, China has recently established a number of primate animal models for human diseases and achieved marked scientific progress on infectious diseases, cardiovascular diseases, endocrine diseases, reproductive diseases, neurological diseases, and ophthalmic diseases, etc. Advances in these fields via NHP models will undoubtedly further promote the development of China's life sciences and pharmaceutical industry, and enhance China's position as a leader in NHP research. This review covers the current status of NHPs in China and other areas, highlighting the latest developments in disease models using NHPs, as well as outlining basic problems and proposing effective countermeasures to better utilize NHP resources and further foster NHP research in China.
  • loading
  • [1]
    Akari H, Iwasaki Y, Yoshida T, Iijima S. 2009. Non-human primate surrogate model of hepatitis C virus infection. Microbiology and Immunology, 53(1): 53-57.
    Ambrose Z, Kewalramani VN, Bieniasz PD, Hatziioannou T. 2007. HIV/AIDS: in search of an animal model. Trends in Biotechnology, 25(8): 333-337.
    Anderson MS, Bluestone JA. 2005. The NOD mouse: a model of immune dysregulation. Annual Review of Immunology, 23(1): 447-485.
    Baas T, Baskin CR, Diamond DL, García-Sastre A, Bielefeldt-Ohmann H, Tumpey TM, Thomas MJ, Carter VS, Teal TH, Van Hoeven N, Proll S, Jacobs JM, Caldwell ZR, Gritsenko MA, Hukkanen RR, Camp DG 2nd, Smith RD, Katze MG. 2006. Integrated molecular signature of disease: analysis of influenza virus-infected macaques through functional genomics and proteomics. Journal of Virology, 80(21): 10813-10828.
    Baccini M, Biggeri A, Accetta G, Kosatsky T, Katsouyanni K, Analitis A, Anderson HR, Bisanti L, D'Ippoliti D, Danova J, Forsberg B, Medina S, Paldy A, Rabczenko D, Schindler C, Michelozzi P. 2008. Heat effects on mortality in 15 European cities. Epidemiology, 19(5): 711-719.
    Bukh J, Apgar CL, Yanagi M. 1999. Toward a surrogate model for hepatitis C virus: an infectious molecular clone of the GB virus-B hepatitis agent. Virology, 262(2): 470-478.
    Bukh J, Apgar CL, Govindarajan S, Emerson SU, Purcell RH. 2001. Failure to infect rhesus monkeys with hepatitis C virus strains of genotypes 1a, 2a or 3a. Journal of Viral Hepatitis, 8(3): 228-231.
    Carlsson HE, Schapiro SJ, Farah I, Hau J. 2004. Use of primates in research: a global overview. American Journal of Primatology, 63(4): 225-237.
    Carroll TD, Matzinger SR, Genescà M, Fritts L, Colòn R, Mcchesney MB, Miller CJ. 2008. Interferon-induced expression of MxA in the respiratory tract of rhesus macaques is suppressed by influenza virus replication. The Journal of Immunology, 180(4): 2385-2395.
    Chan A, Chong K-Y, Martinovich C, Simerly C, Schatten G. 2001. Transgenic monkeys produced by retroviral gene transfer into mature oocytes. Science, 291(5502): 309-312.
    Chen N, Meng FG, Zhang JG, Zhang K, Liu HG, Meng DW, Liu C, Ge Y. 2013. The establishment of macaque models of temporal lobe epilepsy. Chinese Journal of Neurosurgery, 29(5): 533-537. (in Chinese)
    Chen YX, Deng W, Jia CS, Dai XW, Zhu H, Kong Q, Huang L, Liu Y, Ma CM, Li JM, Xiao C, Liu Y, Wei Q, Qin C. 2009. Pathological lesions and viral localization of influenza A (H5N1) virus in experimentally infected Chinese rhesus macaques: implications for pathogenesis and viral transmission. Archives of Virology, 154(2): 227-233.
    Chen YC, Niu YY, Ji WZ. 2012. Transgenic nonhuman primate models for human diseases: approaches and contributing factors. Journal of Genetics and Genomics, 39(6): 247-251.
    Chu XX, Rizak JD, Yang SC, Wang JH, Ma YY, Hu XT. 2014. A natural model of behavioral depression in postpartum adult female cynomolgus monkeys (Macaca fascicularis). Zoological Research, 35(3): 174-181.
    Cillóniz C, Shinya K, Peng X, Korth MJ, Proll SC, Aicher LD, Carter VS, Chang JH, Kobasa D, Feldmann F, Strong JE, Feldmann H, Kawaoka Y, Katze MG. 2009. Lethal influenza virus infection in macaques is associated with early dysregulation of inflammatory related genes. PLoS Pathogens, 5(10): e1000604.
    Cong Z, Jiang H, Jin G, Chen T, Wang W, Tao Z, Yao N, Xiong J, Wu FX, Chen ZW, Wei Q. 2011a. Titration of a SHIV1157ipd3N4 stock by intravenous inoculation of Chinese-origin rhesus macaques. Chinese Journal of Comparative Medicine, 21(4): 12-15. (in Chinese)
    Cong Z, Liu H, Duo JY, Wang W, Jiang H, Gao H, Yang ZW, Fleury S, Wei Q, Qin C. 2011b. Efficient repeated low-dose intravaginal infection with SHIV (SF162p3) in Chinese-origin rhesus macaques. Chinese Journal of Comparative Medicine, 21(2): 44-48. (in Chinese)
    Cyranoski D. 2003. China launches primate centre to broaden medical use of monkeys. Nature, 424(6946): 239-240.
    Cyranoski D. 2004. China takes steps to secure pole position in primate research. Nature, 432(7013): 3.
    Dai J, Brooks DI, Sheinberg DL. 2013. Optogenetic and electrical microstimulation systematically bias visuospatial choice in primates. Current Biology, 24(1): 63-69.
    Dai Y, Sun XH, Guo WY, Yang YM, Yu XB, Qian SH, Shen Y, Jin XH. 2005. Establishment of chronic glaucoma model in rhesus monkeys and evaluation of their related biological characteristics. Acta Laboratorium Animalis Scientifica Sinica, 13(2): 68-71. (in Chinese)
    Deisseroth K. 2010. Optogenetics. Nature Methods, 8(1): 26-29.
    Delovitch TL, Singh B. 1997. The nonobese diabetic mouse as a model of autoimmune diabetes: immune dysregulation gets the NOD. Immunity, 7(6): 727-738.
    Diedrich CR, Mattila JT, Klein E, Janssen C, Phuah J, Sturgeon TJ, Montelaro RC, Lin PL, Flynn JL. 2010. Reactivation of latent tuberculosis in cynomolgus macaques infected with SIV is associated with early peripheral T cell depletion and not virus load. PLoS One, 5(3): e9611.
    Ding F, Luan L, Ai Y, Walton A, Gerhardt GA, Gash DM, Grondin R, Zhang Z. 2008. Development of a stable, early stage unilateral model of Parkinson's disease in middle-aged rhesus monkeys. Experimental Neurology, 212(2): 431-439.
    Enserink M. 2001. Driving a stake into resurgent TB. Science, 293(5528): 234-235.
    Fan SF, Gao YW, Shinya K, Li CK, Li Y, Shi JZ, Jiang YP, Suo YB, Tong TG, Zhong GX, Song JS, Zhang Y, Tian GB, Guan YT, Xu XN, Bu Z, Kawaoka Y, Chen H. 2009. Immunogenicity and protective efficacy of a live attenuated H5N1 vaccine in nonhuman primates. PLoS Pathogens, 5(5): e1000409.
    Feigin VL, Lawes CM, Bennett DA, Anderson CS. 2003. Stroke epidemiology: a review of population-based studies of incidence, prevalence, and case-fatality in the late 20th century. The Lancet Neurology, 2(1): 43-53.
    Feng YF, Wang W, Xu Y, Cong Z, Jiang H, Tong W, Wu XX, Lu YZ, Wei Q. 2007. Comparative study on acute manifestation of rhesus monkeys infected with SIVmac251 by different routes. Chinese Journal of Comparative Medicine, 17(2): 80-83. (in Chinese)
    Fujiyama A, Watanabe H, Toyoda A, Taylor TD, Itoh T, Tsai SF, Park HS, Yaspo ML, Lehrach H, Chen Z, Fu G, Saitou N, Osoegawa K, de Jong PJ, Suto Y, Hattori M, Sakaki Y. 2002. Construction and analysis of a human-chimpanzee comparative clone map. Science, 295(5552): 131-134.
    Gao HN, Lu HZ, Cao B, Du B, Shang H, Gan JH, Lu SH, Yang YD, Fang Q, Shen YZ, Xi XM, Gu Q, Zhou XM, Qu HP, Yan Z, Li FM, Zhao W, Gao ZC, Wang GF, Ruan LX, Wang WH, Ye J, Cao HF, Li XW, Zhang WH, Fang XC, He J, Liang WF, Xie J, Zeng M, Wu XZ, Li J, Xia Q, Jin ZC, Chen Q, Tang C, Zhang ZY, Hou BM, Feng ZX, Sheng JF, Zhong NS, Li LJ. 2013a. Clinical findings in 111 cases of Influenza A (H7N9) virus infection. New England Journal of Medicine, 368(24): 2277-2285.
    Gao R, Cao B, Hu Y, Feng Z, Wang D, Hu W, Chen J, Jie Z, Qiu H, Xu K, Xu X, Lu H, Zhu W, Gao Z, Xiang N, Shen Y, He Z, Gu Y, Zhang Z, Yang Y, Zhao X, Zhou L, Li X, Zou S, Zhang Y, Li X, Yang L, Guo J, Dong J, Li Q, Dong L, Zhu Y, Bai T, Wang S, Hao P, Yang W, Zhang Y, Han J, Yu H, Li D, Gao GF, Wu G, Wang Y, Yuan Z, Shu Y. 2013b. Human infection with a novel avian-origin influenza A (H7N9) virus. New England Journal of Medicine, 368(20): 1888-1897.
    Ge XM, Huang GY, Liu W, Chen J, Jiang YL, Huang DC, Li RJ, Wang SS. 1989. A study of developmental pathology of experimental infection by human hepatitis(HHBV) in Macaca Assamensis. Chinese Journal of Zoonoses, 5(5): 24-26. (in Chinese)
    Geissmann T, Lwin N, Aung SS, Aung TN, Aung ZM, Hla TH, Grindley M, Momberg F. 2011. A new species of snub-nosed monkey, genus Rhinopithecus Milne-Edwards, 1872 (Primates, Colobinae), from northern Kachin state, northeastern Myanmar. American Journal of Primatology, 73(1): 96-107.
    Guo M, Ho WZ. 2014. Animal models to study Mycobacterium tuberculosis and HIV co-infection. Zoological Research, 35(3): 163-169.
    Hao X. 2007. Monkey research in China: developing a natural resource. Cell, 129(6): 1033-1036.
    Harrington M. 2010. From HIV to tuberculosis and back again: a tale of activism in 2 pandemics. Clinical Infectiouse Diseases, 50(S3): S260-S266.
    Hashimoto I, Hagiwara A. 1982. Studies on the pathogenesis of and propagation of enterovirus 71 in poliomyelitis-like disease in monkeys. Acta Neuropathologica, 58(2): 125-132.
    Hashimoto I, Hagiwara A. 1983. Comparative studies on the neurovirulence of temperature-sensitive and temperature-resistant viruses of enterovirus 71 in monkeys. Acta Neuropathologica, 60(3-4): 266-270.
    Hashimoto I, Hagiwara A, Kodama H. 1978. Neurovirulence in cynomolgus monkeys of enterovirus 71 isolated from a patient with hand, foot and mouth disease. Archives of Virology, 56(3): 257-261.
    Hayden EC. 2008. US plans more primate research. Nature, 453(7194): 439.
    He RQ, Lu J, Miao JY. 2010. Formaldehyde stress. Science China Life Sciences, 53(12): 1399-1404.
    He S, Wang D, Wei L. 2013. Practical and critical instruction for nonhuman primate diabetic models. Transplantation Proceedings, 45(5): 1856-1865.
    Hu YW, Lu SH, Song ZG, Wang W, Hao P, Li JH, Zhang XN, Yen HL, Shi BS, Li T, Guan WC, Xu L, Liu Y, Wang S, Zhang X, Tian D, Zhu Z, He J, Huang K, Chen H, Zheng L, Li X, Ping J, Kang B, Xi X, Zha L, Li Y, Zhang Z, Peiris M, Yuan Z. 2013. Association between adverse clinical outcome in human disease caused by novel influenza A H7N9 virus and sustained viral shedding and emergence of antiviral resistance. The Lancet, 381(9885): 2273-2279.
    Huang J. 2010. Establishment of the Postpartum Hemorrhage Model of Cesarean Section in Macaca fascicularis with Uterine Atony Induced by Medicine. Master Thesis, Guangzhou Medicine College. (in Chinese)
    Itoh Y, Shinya K, Kiso M, Watanabe T, Sakoda Y, Hatta M, Muramoto Y, Tamura D, Sakai-Tagawa Y, Noda T, Sakabe S, Imai M, Hatta Y, Watanabe S, Li C, Yamada S, Fujii K, Murakami S, Imai H, Kakugawa S, Ito M, Takano R, Iwatsuki-Horimoto K, Shimojima M, Horimoto T, Goto H, Takahashi K, Makino A, Ishigaki H, Nakayama M, Okamatsu M, Takahashi K, Warshauer D, Shult PA, Saito R, Suzuki H, Furuta Y, Yamashita M, Mitamura K, Nakano K, Nakamura M, Brockman-Schneider R, Mitamura H, Yamazaki M, Sugaya N, Suresh M, Ozawa M, Neumann G, Gern J, Kida H, Ogasawara K, Kawaoka Y. 2009. In vitro and in vivo characterization of new swine-origin H1N1 influenza viruses. Nature, 460(7258): 1021-1025.
    Jin X, Zeng L, He S, Chen Y, Tian B, Mai G, Yang G, Wei L, Zhang Y, Li H, Wang L, Qiao C, Cheng J, Lu Y. 2010. Comparison of single high-dose streptozotocin with partial pancreatectomy combined with low-dose streptozotocin for diabetes induction in rhesus monkeys. Experimental Biology and Medicine, 235(7): 877-885.
    Kadowaki T. 2000. Insights into insulin resistance and type 2 diabetes from knockout mouse models. Journal of Clinical Investigation, 106(4): 459-465.
    Kaiser J. 2013. Research in limbo as harvard moves to close center. Science, 340(6132): 535-535.
    Kamath S, Chavez AO, Gastaldelli A, Casiraghi F, Halff GA, Abrahamian GA, Davalli AM, Bastarrachea RA, Comuzzie AG, Guardado-Mendoza R, Jimenez-Ceja LM, Mattern V, Paez AM, Ricotti A, Tejero ME, Higgins PB, Rodriguez-Sanchez IP, Tripathy D, DeFronzo RA, Dick EJ Jr, Cline GW, Folli F. 2011. Coordinated defects in hepatic long chain fatty acid metabolism and triglyceride accumulation contribute to insulin resistance in non-human primates. PLoS One, 6(11): e27617.
    Kaushal D, Mehra S, Didier PJ, Lackner AA. 2012. The non-human primate model of tuberculosis. Journalof Medical Primatology, 41(3): 191-201.
    Kilbourne ED. 2006. Influenza pandemics of the 20th century. Emerging Infectious Diseases, 12(1): 9-14.
    Kobasa D, Jones SM, Shinya K, Kash JC, Copps J, Ebihara H, Hatta Y, Kim JH, Halfmann P, Hatta M, Feldmann F, Alimonti JB, Fernando L, Li Y, Katze MG, Feldmann H, Kawaoka Y. 2007. Aberrant innate immune response in lethal infection of macaques with the 1918 influenza virus. Nature, 445(7125): 319-323.
    Kuang YQ, Tang X, Liu FL, Jiang XL, Zhang YP, Gao GX, Zheng YT. 2009. Genotyping of TRIM5 locus in Northern pig-tailed macaques (Macaca leonina), a primate species susceptible to human immunodeficiency virus type 1 infection. Retrovirology, 6(1): 58.
    Laddy DJ, Yan J, Khan AS, Andersen H, Cohn A, Greenhouse J, Lewis M, Manischewitz J, King LR, Golding H, Draghia-Akli R, Weiner DB. 2009. Electroporation of synthetic DNA antigens offers protection in nonhuman primates challenged with highly pathogenic avian influenza virus. Journal of Virology, 83(9): 4624-4630.
    Lee MS, Chang LY. 2010. Development of enterovirus 71 vaccines. Expert Review of Vaccines, 9(2): 149-156.
    Lei AH, Pang W, Zhang GH, Zheng YT. 2013. Use and research of pigtailed macaques in nonhuman primate HIV/AIDS models. Zoological Research, 34(2): 77-88. (in Chinese)
    Li MH, Li SY, Xia HJ, Wang L, Wang YY, Zhang GH, Zheng YT. 2007. Establishment of AIDS animal model with SIVmac239 infected Chinese rhesus monkey. Virologica Sinica, 22(6): 509-516.
    Li FX, Lu J, Xu YJ, Tong ZQ, Nie CL, He RQ. 2008. Formaldehyde-mediated chronic damage may be related to sporadic neurodegeneration. Progress in Biochemistry and Biophysics, 35(4): 393-400.
    Li SY, Xia HJ, Dai ZX, Zhang GH, Fan B, Li MH, Wang RR, Zheng YT. 2012. Dynamics and functions of CD4+ CD25high regulatory T lymphocytes in Chinese rhesus macaques during the early stage of infection with SIVmac239. Archives of Virology, 157(5): 961-967.
    Li T, Zhu S, Shuai L, Xu Y, Yin S, Bian Y, Wang Y, Zuo B, Wang W, Zhao S, Zhang L, Zhang J, Gao GF, Allain JP, Li CY. 2014. Infection of common marmosets with hepatitis C virus/GB virus-B chimeras. Hepatology, 59(3): 789-802.
    Li ZX, Lin ZY. 1983. Classification and distribution of living primates in Yunnan, China. Zoological Research, 4(2): 111-120. (in Chinese)
    Liu D, Shi W, Shi Y, Wang D, Xiao H, Li W, Bi Y, Wu Y, Li X, Yan J, Liu W, Zhao G, Yang W, Wang Y, Ma J, Shu Y, Lei F, Gao GF. 2013. Origin and diversity of novel avian influenza A H7N9 viruses causing human infection: phylogenetic, structural, and coalescent analyses. The Lancet, 381(9881): 1926-1932.
    Liu JN, Zhang LF. 2010. Human enterovirus 71 infection in experimental animals. Acta Laboratorium Animalis Scientia Sinica, 18(3): S5-S9. (in Chinese)
    Liu H, Chen Y, Niu Y, Zhang K, Kang Y, Ge W, Liu X, Zhao E, Wang C, Lin S, Jing B, Si C, Lin Q, Chen X, Lin H, Pu X, Wang Y, Qin B, Wang F, Wang H, Si W, Zhou J, Tan T, Li T, Ji S, Xue Z, Luo Y, Cheng L, Zhou Q, Li S, Sun YE, Ji W. 2014a. TALEN-mediated gene Mutagenesis in rhesus and cynomolgus monkeys. Cell Stem Cell, 14(3): 323-328.
    Liu L, Zhao H, Zhang Y, Wang J, Che Y, Dong C, Zhang X, Na R, Shi H, Jiang L, Wang L, Xie Z, Cui P, Xiong X, Liao Y, Zhao S, Gao J, Tang D, Li Q. 2011. Neonatal rhesus monkey is a potential animal model for studying pathogenesis of EV71 infection. Virology, 412(1): 91-100.
    Liu S, Wang W, Yu XP, Mao J, Rong PF. 2006. Establishment of hemi-Parkinsonism model of rhesus induced by MPTP. Chinese Journal of Medical Imaging Technology, 22(3): 353-356. (in Chinese)
    Liu S, Su ZH, Ai ZD, Li W, Wang W. 2009. Primate models of diabetes induced by streptozotocin. Journal of Clinical Rehabilitative Tissue Engineering Research, 13(50): 9917-9923. (in Chinese)
    Liu X, Tonegawa S. 2010. Optogenetics 3.0. Cell, 141(1): 22-24.
    Liu YJ, Zhang GF, Lu Q. 1992. A monkey paralysis model of unilateral motor cortex lesion. Journal of Capital Institute of Medicine, 13(4): 264-268. (in Chinese)
    Liu Z, Zhou X, Zhu Y, Chen ZF, Yu B, Wang Y, Zhang CC, Nie YH, Sang X, Cai YJ, Zhang YF, Zhang C, Zhou WH, Sun Q, Qiu Z. 2014b. Generation of a monkey with MECP2 mutations by TALEN-based gene targeting. Neuroscience Bulletin, 30(3): 381-386.
    Long YC, Momberg F, Ma J, Wang Y, Luo YM, Li HS, Yang GL, Li M. 2012. Rhinopithecus strykeri Found in China. American Journal of Primatology, 74(10): 871-873.
    Lu SN, Wang GL, Zhang YC, Zhang HD, Zheng JW. 1999. Treatment effect of lingyi capsule for the withdrawal syndromes in morphine-dependent monkeys. Chinese Journal of Drug Dependence, 8(1): 61-63. (in Chinese)
    Lu SY, He ZL, Yang FM, Yu WH, Zhao Y, Li YY, Wang JB, Chen LX, Qi SD. 2013. Establishment of a rhesus monkey model of type 2 diabetes mellitus and analysis of some of its clinical features. Chinese Journal of Comparative Medicine, 23(6): 1-5. (in Chinese)
    Lu YR, Wang LN, Jin X, Chen YN, Cong C, Yuan Y, Li YC, Tang WD, Li HX, Wu XT, Li YP, Wang L, Cheng JQ. 2008. A preliminary study on the feasibility of gene expression profile of rhesus monkey detected with human microarray. Transplantation Proceedings, 40(2): 598-602.
    Lü Q, Deng W, Bao LL, Xu LL, Li FD, Chen T, Zhan LJ, Qin C. 2011. Endotracheal intubation in oculation of H5N1 virus and detection of virus in organ tissues in the rhesus macaques. Chinese Journal of Comparative Medicine, 21(12): 56-60. (in Chinese)
    Mounts AW, Kwong H, Izurieta HS, Ho Y, Au T, Lee M, Buxton Bridges C, Williams SW, Mak KH, Katz JM, Thompson WW, Cox NJ, Fukuda K. 1999. Case-control study of risk factors for avian influenza A (H5N1) disease, Hong Kong, 1997. Journal of Infectious Diseases, 180(2): 505-508.
    Nagata N, Shimizu H, Ami Y, Tano Y, Harashima A, Suzaki Y, Sato Y, Miyamura T, Sata T, Iwasaki T. 2002. Pyramidal and extrapyramidal involvement in experimental infection of cynomolgus monkeys with enterovirus 71.Journal of Medical Virology, 67(2): 207-216.
    Nagata N, Iwasaki T, Ami Y, Tano Y, Harashima A, Suzaki Y, Sato Y, Hasegawa H, Sata T, Miyamura T, Shimizu H. 2004. Differential localization of neurons susceptible to enterovirus 71 and poliovirus type 1 in the central nervous system of cynomolgus monkeys after intravenous inoculation. Journal of General Virology, 85(10): 2981-2989.
    Ni W, Li YM, Guan YG, Zhu XB, Wang TH, Feng ZT. 2005. Evaluation of neurological function following establishment of spinal cord hemisection. Journal Sichuan University, 36(3): 328-330. (in Chinese)
    Niu YY, Shen B, Cui YQ, Chen YC, Wang JY, Wang L, Kang Y, Zhao XY, Si W, Li W, Xiang AP, Zhou JK, Guo XJ, Bi Y, Si CY, Hu B, Dong GY, Wang H, Zhou ZM, Li TQ, Tan T, Pu XQ, Wang F, Ji SH, Zhou Q, Huang XX, Ji WZ, Sha JH. 2014. Generation of gene-modified cynomolgus monkey via Cas9/RNA-mediated gene targeting in one-cell embryos. Cell, 156(4): 836-843.
    Niu YY, Yu Y, Bernat A, Yang SH, He XC, Guo XY, Chen DL, Chen YC, Ji SH, Si W, Lü YQ, Tan T, Wei QA, Wang H, Shi L, Guan JA, Zhu XM, Afanassieff M, Savatier P, Zhang K, Zhou Q, Ji WZ. 2010. Transgenic rhesus monkeys produced by gene transfer into early-cleavage–stage embryos using a simian immunodeficiency virus-based vector. Proceedings of the National Academy of Sciences of the United States of America, 107(41): 17663-17667.
    Norol F, Merlet P, Isnard R, Sebillon P, Bonnet N, Cailliot C, Carrion C, Ribeiro M, Charlotte F, Pradeau P. 2003. Influence of mobilized stem cells on myocardial infarct repair in a nonhuman primate model. Blood, 102(13): 4361-4368.
    Obenauer JC, Denson J, Mehta PK, Su X, Mukatira S, Finkelstein DB, Xu X, Wang J, Ma J, Fan Y, Rakestraw KM, Webster RG, Hoffmann E, Krauss S, Zheng J, Zhang Z, Naeve CW. 2006. Large-scale sequence analysis of avian influenza isolates. Science, 311(5767): 1576-1580.
    Orlic D, Kajstura J, Chimenti S, Limana F, Jakoniuk I, Quaini F, Nadal-Ginard B, Bodine DM, Leri A, Anversa P. 2001. Mobilized bone marrow cells repair the infarcted heart, improving function and survival. Proceedings of the National Academy of Sciences of the United States of America, 98(18): 10344-10349.
    Pan QH, Ben KL.1984. The review and prospect of primatology in China. Zoological Research, 5(4S): 1-6. (in Chinese)
    Pan XH, He B, Pang RQ, Tang LW, Li JL, Chen XG. 2006. Establishment and evaluation of the ischemic cerebral infarction model in monkey. Journal of Tropical Medicine, 6(4): 400-402. (in Chinese)
    Pang W, Lü LB, Wang Y, Li G, Huang DT, Lei AH, Zhang GH, Zheng YT. 2013. Measurement and analysis of hematology and blood chemistry parameters in northern pig-tailed macaques (Macaca leonina). Zoological Research, 34(2): 89-96. (in Chinese)
    Pérez-Otaño I, Herrero MT, Oset C, De Ceballos ML, Luquin MR, Obeso JA, Del Río J. 1991. Extensive loss of brain dopamine and serotonin induced by chronic administration of MPTP in the marmoset. Brain Research, 567(1): 127-132.
    Perretta G. 2009. Non-human primate models in neuroscience research. Scandinavian Journal of Laboratory Animal Science, 36(1): 77-85.
    Pound LD, Kievit P, Grove KL. 2014. The nonhuman primate as a model for type 2 diabetes. Current Opinion in Endocrinology, Diabetes and Obesity, 21(2): 89-94.
    Qiao CF, Tian BL, Mai G, Wei LL, Jin X, Ren Y, Chen YN, Li HX, Li YP, Wang L, Cheng JQ, Lu YR. 2009. Induction of diabetes in rhesus monkeys and establishment of insulin administration strategy. Transplantation Proceedings, 41(1): 413-417.
    Qiao M, Zhao Q, Zhang H, Wang H, Xue L, Wei S. 2007. Isolating with physical restraint low status female monkeys during luteal phase might make an appropriate premenstrual depression syndrome model. Journal of Affective Disorders, 102(1-3): 81-91.
    Rijnbrand R, Yang Y, Beales L, Bodola F, Goettge K, Cohen L, Lanford RE, Lemon SM, Martin A. 2005. A chimeric GB virus B with 5′nontranslated RNA sequence from hepatitis C virus causes hepatitis in tamarins. Hepatology, 41(5): 986-994.
    Rimmelzwaan GF, Baars M, van Amerongen G, van Beek R, Osterhaus AD. 2001. A single dose of an ISCOM influenza vaccine induces long-lasting protective immunity against homologous challenge infection but fails to protect Cynomolgus macaques against distant drift variants of influenza A (H3N2) viruses. Vaccine, 20(1-2): 158-163.
    Sellandi TM, Thakar AB, Baghel MS. 2012. Clinical study of tribulus terrestris Linn. in oligozoospermia: a double blind study. Ayurveda, 33(3): 356-364.
    Shen H. 2013. Precision gene editing paves way for transgenic monkeys. Nature, 503(7474): 14-15.
    Shen PQ, Yang SF. 2003. The current status and the future of laboratory primates in China. Laboratory Animal Science and Management, 20(S1): 41-45. (in Chinese)
    Sun XM, Chen Y, Li CH, Peng H, Lin SL, Dai JJ. 2006. Study on establishment of oligozoospermia animal model in cynomolgus monkey. Laboratory Animal Science and Management, 23(2): 22-25.
    Sy C, Liu L, Ding Y. 2014. Ongoing progress and new developments in the clinical approach to stroke and cerebrovascular disease-memos from the 2014 Tiantan International Stroke Conference. Neurological Research, 36(5): 389-390.
    Tang XH, Cao YL, Yang ZX, Zhao FX. 2012. Reproductive traits of polycystic ovary syndrome in female rhesus monkeys. Zoological Research, 33(1): 37-42.
    Tian CY, Ma YY. 2014. Involve both genetic and environmental factors to build monkey models of mental disorders. Zoological Research, 35(3): 170-171.
    Tian W, Zhang Y, Sun L, Wang ZM. 2010. Establishment and evaluations of the spinal cord injury model. Chinese Journal of Rehabilitation Theory and Practice, 16(3): 221-223. (in Chinese)
    Tong ZQ, Han CS, Luo WH, Wang XH, Li H, Luo HJ, Zhou JN, Qi JS, He RQ. 2012. Accumulated hippocampal formaldehyde induces age-dependent memory decline. AGE, 35(3): 583-596.
    Tong ZQ, Zhang JL, Luo WH, Wang WS, Li FX, Li H, Luo HJ, Lu J, Zhou JN, Wan Y, He RQ. 2011. Urine formaldehyde level is inversely correlated to mini mental state examination scores in senile dementia. Neurobiology of Aging, 32(1): 31-41.
    Van Der Worp HB, Howells DW, Sena ES, Porritt MJ, Rewell S, O'collins V, Macleod MR. 2010. Can animal models of disease reliably inform human studies? PLoS Medicine, 7(3): e1000245.
    Van Rompay KK. 2012. The use of nonhuman primate models of HIV infection for the evaluation of antiviral strategies. AIDS Research and Human Retroviruses, 28(1): 16-35.
    Wadman M. 2011a. Animal rights: chimpanzee research on trial. Nature, 474(7351): 268-271.
    Wadman M. 2011b. Chimp research under scrutiny. Nature, 480(7378): 424-425.
    Wang JJ, Li W, Diao HL, Liu LZ, Tang DH, Yang LX, Dong ZH, Na RX, Yu LC, Zhang Y. 2011a. Biological characteristics related to the transmission of enterovirus 71 in neonatal rhesus monkeys. Journal of Microbies and Infections, 6(3): 133-138. (in Chinese)
    Wang W, Liu Q, Xu Y, Feng YF, Cong Z, Tong W, Jiang H, Yang GB, Wei Q, Qin C. 2011b. Establishment of a Chinese-origin rhesus macaque model of SHIV-KB9 virus infection. Chinese Journal of Comparative Medicine, 21(2): 1-6. (in Chinese)
    Wang YJ, Ye HH, Shao JS. 2004. Discussion of rhesus monkey model of the spontaneous diabetes. Chinese Journal of Laboratory Animal Science, 14(1): 13-15. (in Chinese)
    Wang Y, Mo PZ, Tang ZJ, Xian QY, Huang ZX, Rao Y, Bao R, Guo M, Wang X, Li XD, Huo WZ. 2012. Establishment and evaluation of a Chinese rhesus model of tuberculosis. Chinese Journal of Tuberculosis and Respiratory Diseases, 35(11): 843-848. (in Chinese)
    Wu Z, Sun X, Sullivan SG, Detels R. 2006. HIV testing in China. Science, 312(5779): 1475-1476.
    Xia HJ, Chen CS. 2011. Progress of non-human primate animal models of cancers. Zoological Research, 32(1): 70-80.
    Xia HJ, Ma JP, Zhang GH, Han JB, Wang JH, Zheng YT. 2011. Effect of plasma viremia on apoptosis and immunophenotype of dendritic cells subsets in acute SIVmac239 infection of Chinese rhesus macaques. PLoS One, 6(12): e29036.
    Xia HJ, Zhang GH, Ma JP, Dai ZX, Li SY, Han J-B, Zheng YT. 2010. Dendritic cell subsets dynamics and cytokine production in SIVmac239-infected Chinese rhesus macaques. Retrovirology, 7: 102.
    Xia HJ, Zhang GH, Wang RR, Zheng YT. 2009. The influence of age and sex on the cell counts of peripheral blood leukocyte subpopulations in Chinese rhesus macaques. Cellular and Molecular Immunology, 6(6): 433-440.
    Xian QY, Tang ZJ, Li XD, Wang Y, Bao R, Guo M, Liu JY. 2010. Application of fiberoptic bronchoscope in establishment of nonhuman primate model for mycobacterium tuberculosis infection. Medical Journal of Wuhan University, 31(6): 713-716. (in Chinese)
    Xu CL, Chen YM, Xu ZY, Lu Q, Xu Q, Shen YP, Su JF, Long Y. 2009. Establishment of cynomolgus monkey diabetic models. Journal of Guangzhou University of Traditional Chinese Medicine, 26(1): 91-94. (in Chinese)
    Xu JH, Deng YX, Qui WJ, Zhou ZP, Zhang HY, Zeng YD. 2012. The establishment and evaluation of middle cerebral artery occlusion model in monkeys by interventional management. Journal of Interventional Radiology, 21(7): 578-581. (in Chinese)
    Xu L. 2011. Animal models of human diseases. Zoological Research, 32(1): 2-3. (in Chinese)
    Xu L, Zhang Y, Liang B, Lü LB, Chen CS, Chen YB, Zhou JM, Yao YG. 2013. Tree shrews under the spot light: emerging model of human diseases. Zoological Research, 34(2): 59-69. (in Chinese)
    Yan G, Zhang G, Fang X, Zhang Y, Li C, Ling F, Cooper DN, Li Q, Li Y, van Gool AJ, Du H, Chen J, Chen R, Zhang P, Huang Z, Thompson JR, Meng Y, Bai Y, Wang J, Zhuo M, Wang T, Huang Y, Wei L, Li J, Wang Z, Hu H, Yang P, Le L, Stenson PD, Li B, Liu X, Ball EV, An N, Huang Q, Zhang Y, Fan W, Zhang X, Li Y, Wang W, Katze MG, Su B, Nielsen R, Yang H, Wang J, Wang X, Wang J. 2011. Genome sequencing and comparison of two nonhuman primate animal models, the cynomolgus and Chinese rhesus macaques. Nature Biotechnology, 29(11): 1019-1023.
    Yan T, Rizak JD, Yang SC, Li H, Huang BH, Ma YY, Hu XT. 2014. Acute morphine treatments alleviate tremor in 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine-treated monkeys. PLoS One, 9(2): e88404.
    Yang MF, Miao JY, Rizak JD, Zhai RW, Wang ZB, Anwar TH, Li T, Zheng N, Wu SH, Zheng YW, Fan XN, Yang JZ, Wang JH, Ma YY, Lü LB, He RQ, Hu XT. 2014. Alzheimer's disease and methanol toxicity (part 2): lessons from four rhesus macaques (Macaca mulatta) chronically fed methanol. Journal of Alzheimers Disease, 41(4): 1131-1147.
    Yang P, Han P, Hou J, Zhang L, Song H, Xie Y, Chen Y, Xie H, Gao F, Kang YJ. 2011. Electrocardiographic Characterization of rhesus monkey model of ischemic myocardial infarction induced by left anterior descending artery ligation. Cardiovascular Toxicology, 11(4): 365-372.
    Yang ZG, Xu JZ, Ju JL, Xu YH, Qiu H, Yue MY, Meng JH. 2006. China rhesus model of HEV gene type-Ⅳ infection. Jiangsu Medical Journal, 32(2): 147-148. (in Chinese)
    Yao N, Wang W, Cong Z, Chen T, Jin G, Tao Z, Chen ZW, Wei Q. 2011. RT-SHIV infected and passaged in Chinese-origin rhesus monkeys. Chinese Journal of Comparative Medicine, 21(4): 16-20. (in Chinese)
    Yeh RW, Sidney S, Chandra M, Sorel M, Selby JV, Go AS. 2010. Population trends in the incidence and outcomes of acute myocardial infarction. New England Journal of Medicine, 362(23): 2155-2165.
    You ZL, Ma HX, Chen JM, Wang RG, Liang XY, Liu WE. 2003. Establishment of animal model with metrorrhagia induced by endometritis in experimental rhesus monkey. Chinese Journal of Comparative Medicine, 13(5): 310-312. (in Chinese)
    Zak O, Sande MA. 1999. Handbook of Animal Models of Infection. New York: Academic Press.
    Zha WG, Guo XM, Wang XX. 2006. The lateral hemisection of cervical spinal cord injury model in rhesus monkey. Chinese Journal of Neurosurgery, 22(5): 309-311. (in Chinese)
    Zhang DM, Guo XH, Guo L, Zhang ZM, Zhang ZX, Hou YC, Zheng CL, Zeng QY, Jiang JX. 1999. Establishment of animal model of heroin-dependent macaca mulatta. Chinese Journal of Modern Applied Pharmacy, 16(6): 12-14. (in Chinese)
    Zhang L, Jiang CC, Xu B, Xu HJ, Li XJ, Huang KM. 2006. Establishment of the parkinson’s disease rhesus monkey models under the stereotactic unilateral substantia nigra lesion by 6-OHDA. Chinese Journal of Experimental Surgery, 23(12): 1463-1465. (in Chinese)
    Zhang J, Ge SX, Huang GY, Li SW, He ZQ, Wang YB, Zheng YJ, Gu Y, Ng MH, Xia NS. 2004. Significance of serological markers and virological marker for hepatitis E in rhesus monkey model. Chinese Journal of Hepatology, 12(1): 7-10. (in Chinese)
    Zhang J, Ge SX, Huang GY, Li SW, He ZQ, Wang YB, Zheng YJ, Gu Y, Ng MH, Xia NS. 2003. Evaluation of antibody-based and nucleic acid-based assays for diagnosis of hepatitis E virus infection in a rhesus monkey model. Journal of Medical Virology, 71(4): 518-526.
    Zhang J, Ye YQ, Wang Y, Mo PZ, Xian QY, Rao Y, Bao R, Dai M, Liu JY, Guo M, Wang X, Huang ZX, Sun LH, Tang ZJ, Ho WZ. 2011a. M. tuberculosis H37Rv infection of chinese rhesus macaques. Journal of Neuroimmune Pharmacology, 6(3): 362-370.
    Zhang WZ, Zhang ZJ, Liu XL, Rong JQ, Mao PY, Zhao JM, Mao YL. 1998. Study on the experimental model of hepatitis G of macaques. Chinese Journal of Laboratory Animal Science, 8(3): 152-156. (in Chinese)
    Zhang XL, Pang W, Deng DY, Lü LB, Feng Y, Zheng YT. 2014. Analysis of immunoglobulin, complements and CRP levels in serum of captive northern pig-tailed macaques (Macaca leonina). Zoological Research, 35(3): 196-203.
    Zhang Y, Cui W, Liu L, Wang J, Zhao H, Liao Y, Na R, Dong C, Wang L, Xie Z, Gao J, Cui P, Zhang X, Li Q. 2011b. Pathogenesis study of enterovirus 71 infection in rhesus monkeys. Laboratory Investigation, 91(9): 1337-1350.
    Zhang YC, Jin LS, Gao LH, Peng BL, He H, Ji F, Hao XF, Zhang XJ, Tang XB, Rao JH, Liu XM. 2012. Study on the model of T2DM of cynomolgus iduced by high-energy diet. Progress in Veterinary Medicine, 33(8): 47-52. (in Chinese)
    Zheng X. 2012. Monitoring of the Virus Antibodies During the Process of SPF Non-human Primates Populations Establishment. Master Thesis, Soochow University. (in Chinese)
    Zhu H, Li Q, Feng M, Chen YX, Li H, Sun JJ, Zhao CH, Wang RZ, Qin C. 2009. Establishment and evaluation on the intracerebral hemorrhage model of cynomolgus macaques. Chinese Journal of Comparative Medicine, 19(7): 29-32. (in Chinese)
    Zhu H, Li Q, Xu YF, Feng M, Li H, Sun JJ, Zhao CH, Wang RZ, Qin C. 2008. The Establishment of photochemical thrombosis animal model in cynomolgus macaques. Chinese Journal of Comparative Medicine, 18(9): 32-34. (in Chinese)
    Zhu Q, Xiao ZN, Sun XM, Hu M, Liu H, Hu ZL. 2013. Model establishment of corneal endothelial injury by phacoemulsification in rhesus monkeys. Recent Advances in Ophthalmology, 33(2): 110-112. (in Chinese)
  • 加载中


    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Article Metrics

    Article views (1076) PDF downloads(1662) Cited by()
    Proportional views


    DownLoad:  Full-Size Img  PowerPoint