Volume 35 Issue 3
May  2014
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Xun-Xun CHU, Joshua Dominic Rizak, Shang-Chuan YANG, Jian-Hong WANG, Yuan-Ye MA, Xin-Tian HU. A natural model of behavioral depression in postpartum adult female cynomolgus monkeys (Macaca fascicularis). Zoological Research, 2014, 35(3): 174-181. doi: 10.11813/j.issn.0254-5853.2014.3.174
Citation: Xun-Xun CHU, Joshua Dominic Rizak, Shang-Chuan YANG, Jian-Hong WANG, Yuan-Ye MA, Xin-Tian HU. A natural model of behavioral depression in postpartum adult female cynomolgus monkeys (Macaca fascicularis). Zoological Research, 2014, 35(3): 174-181. doi: 10.11813/j.issn.0254-5853.2014.3.174

A natural model of behavioral depression in postpartum adult female cynomolgus monkeys (Macaca fascicularis)

doi: 10.11813/j.issn.0254-5853.2014.3.174
  • Received Date: 2014-03-17
  • Rev Recd Date: 2014-04-17
  • Publish Date: 2014-05-08
  • Postpartum depression (PPD) is a modified form of major depressive disorders (MDD) that can exert profound negative effects on both mothers and infants than MDD. Within the postpartum period, both mothers and infants are susceptible; but because PPD typically occurs for short durations and has moderate symptoms, there exists challenges in exploring and addressing the underlying cause of the depression. This fact highlights the need for relevant animal models. In the present study, postpartum adult female cynomolgus monkeys (Macaca fascicularis) living in breeding groups were observed for typical depressive behavior. The huddle posture behavior was utilized as an indicator of behavioral depression postpartum (BDP) as it has been established as the core depressive-like behavior in primates. Monkeys were divided into two groups: A BDP group (n=6), which were found to spend more time huddling over the first two weeks postpartum than other individuals that formed a non-depression control group (n=4). The two groups were then further analyzed for locomotive activity, stressful events, hair cortisol levels and for maternal interactive behaviors. No differences were found between the BDP and control groups in locomotive activity, in the frequencies of stressful events experienced and in hair cortisol levels. These findings suggested that the postpartum depression witnessed in the monkeys was not related to external factors other than puerperium period. Interestingly, the BDP monkeys displayed an abnormal maternal relationship consisting of increased infant grooming. Taken together, these findings suggest that the adult female cynomolgus monkeys provide a natural model of behavioral postpartum depression that holds a number of advantages over commonly used rodent systems in PPD modeling. The cynomolgus monkeys have a highly-organized social hierarchy and reproductive characteristics without seasonal restriction—similar to humans—as well as much greater homology to humans than rodents. As such, this model may provide a greater translational efficiency and research platform for systematically investigating the etiology, treatment, prevention of PPD.
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  • [1]
    Abbott DH, Keverne EB, Bercovitch FB, Shively CA, Mendoza SP, Saltzman W, Snowdon CT, Ziegler TE, Banjevic M, Garland T, Sapolsky RM. 2003. Are subordinates always stressed? A comparative analysis of rank differences in cortisol levels among primates. Hormones and Behavior, 43(1): 67-82.
    [2]
    Bloch M, Schmidt PJ, Danaceau M, Murphy J, Nieman L, Rubinow DR. 2000. Effects of gonadal steroids in women with a history of postpartum depression. American Journal of Psychiatry, 157(6): 924-930.
    [3]
    Bowlby J. 1962. Attachment and Loss. New York: Basic Books.
    [4]
    Brummelte S, Galea LAM. 2010. Depression during pregnancy and postpartum: contribution of stress and ovarian hormones. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 34(5): 766-776.
    [5]
    Burke HM, Davis MC, Otte C, Mohr DC. 2005. Depression and cortisol responses to psychological stress: a meta-analysis. Psychoneuroendocrinology, 30(9): 846-856.
    [6]
    Canales JZ, Cordas TA, Fiquer JT, Cavalcante AF, Moreno RA. 2010. Posture and body image in individuals with major depressive disorder: a controlled study. Revista Brasileira de Psiquiatria, 32(4): 375-380.
    [7]
    Carroll BJ, Curtis GC, Davies BM, Mendels J, Sugerman AA. 1976. Urinary free cortisol excretion in depression. Psychological Medicine, 6(1): 43-50.
    [8]
    Carroll KA, Maestripieri D. 1998. Infant abuse and neglect in monkeys—A discussion of definitions, epidemiology, etiology, and implications for child maltreatment: reply to Cicchetti (1998) and Mason (1998). Psychological Bulletin, 123(3): 234-237.
    [9]
    Cattet MRL, Christison K, Caulkett NA, Stenhouse GB. 2003. Physiologic responses of grizzly bears to different methods of capture. Journal of Wildlife Diseases, 39(3): 649-654.
    [10]
    Chilton FH, Lee TC, Wilard SL, Ivester P, Sergeant S, Register TC, Shively CA. 2011. Depression and altered serum lipids in cynomolgus monkeys consuming a Western diet. Physiology & Behavior, 104(2): 222-227.
    [11]
    Constable S, Parslow A, Dutton G, Rogers T, Hogg C. 2006. Urinary cortisol sampling: a non invasive technique for examining cortisol-concentrations in the Weddell seal, Leptonychotes weddellii. Zoo Biology, 25(2): 137-144.
    [12]
    Davenport MD, Tiefenbacher S, Lutz CK, Novak MA, Meyer JS. 2006. Analysis of endogenous cortisol concentrations in the hair of rhesus macaques. General and Comparative Endocrinology, 147(3): 255-261.
    [13]
    Douma SL, Husband C, O'Donnell ME, Barwin BN, Woodend AK. 2005. Estrogen-related mood disorders. Advances in Nursing Science, 28(4): 364-375.
    [14]
    England R. 1994. Infant development and management of infant problems in a family setting. Australian Family Physician, 23(10): 1877-1882.
    [15]
    Epperson CN, Ballew J. 2006. Postpartum depression. In: Current Clinical Practice: Psychiatric Disorders in Pregnancy and the Postpartum: Principles and Treatment. Totowa: Humana Press, 41-81.
    [16]
    Feng XL, Wang L, Yang SC, Qin DD, Wang JH, Li CL, Lü LB, Ma YY, Hu XT. 2011. Maternal separation produces lasting changes in cortisol and behavior in rhesus monkeys. Proceedings of the National Academy of Sciences of the United States of America, 108(34): 14312-14317.
    [17]
    Field T. 2010. Postpartum depression effects on early interactions, parenting, and safety practices: a review. Infant Behavior and Development, 33(1): 1-6.
    [18]
    Flores DL, Hendrick VC. 2002. Etiology and treatment of postpartum depression. Current Psychiatry Reports, 4(6): 461-466.
    [19]
    Folkman S, Lazarus RS, Dunkel-Schetter C, Delongis A, Gruen RJ. 1986. Dynamics of a stressful encounter: Cognitive appraisal, coping, and encounter outcomes. Journal of Personality and Social Psychology, 50(5): 992-1003.
    [20]
    Friedman SH, Resnick PJ. 2009. Postpartum depression: an update. Women's Health, 5(3): 287-295.
    [21]
    Galea LAM, Wide JK, Barr AM. 2001. Estradiol alleviates depressive-like symptoms in a novel animal model of post-partum depression. Behavioural Brain Research, 122(1): 1-9.
    [22]
    Gard PR, Handley SL, Parsons AD, Waldron G. 1986. A multivariate investigation of postpartum mood disturbance. The British Journal of Psychiatry, 148(5): 567-575.
    [23]
    Ghubash R, Abou-Saleh MT. 1997. Postpartum psychiatric illness in Arab culture: prevalence and psychosocial correlates. The British Journal of Psychiatry, 171(1): 65-68.
    [24]
    Goodman RL, Hodgen GD. 1978. Post partum patterns of circulating FSH, LH, prolactin, estradiol, and progesterone in nonsuckling cynomolgus monkeys. Steroids, 31(5): 731-744.
    [25]
    Goodman SH, Rouse MH, Connell AM, Broth MR, Hall CM, Heyward D. 2011. Maternal depression and child psychopathology: A meta-analytic review. Clinical Child and Family Psychology Review, 14(1): 1-27.
    [26]
    Green AD, Barr AM, Galea LAM. 2009. Role of estradiol withdrawal in ‘anhedonic' sucrose consumption: a model of postpartum depression. Physiology & Behavior, 97(2): 259-265.
    [27]
    Groer MW, Morgan K. 2007. Immune, health and endocrine characteristics of depressed postpartum mothers. Psychoneuroendocrinology, 32(2): 133-139.
    [28]
    Hammen C. 2005. Stress and depression. Annual Review of Clinical Psychology, 1: 293-319.
    [29]
    Harlow HF, Suomi SJ. 1974. Induced depression in monkeys. Behavioral Biology, 12(3): 273-296.
    [30]
    Harris B, Johns S, Fung H, Thomas R, Walker R, Read G, Riad-Fahmy D. 1989. The hormonal environment of post-natal depression. The British Journal of Psychiatry, 154(5): 660-667.
    [31]
    Harris B, Lovett L, Smith J, Read G, Walker R, Newcombe R. 1996. Cardiff puerperal mood and hormone study. III. Postnatal depression at 5 to 6 weeks postpartum, and its hormonal correlates across the peripartum period. The British Journal of Psychiatry, 168(6): 739-744.
    [32]
    Ising M, Kunzel HE, Binder EB, Nickel T, Modell S, Holsboer F. 2005. The combined dexamethasone/CRH test as a potential surrogate marker in depression. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 29(6): 1085-1093.
    [33]
    Jolley SN, Elmore S, Barnard KE, Carr DB. 2007. Dysregulation of the hypothalamic-pituitary-adrenal axis in postpartum depression. Biological Research for Nursing, 8(3): 210-222.
    [34]
    Keay JM, Singh J, Gaunt MC, Kaur T. 2006. Fecal glucocorticoids and their metabolites as indicators of stress in various mammalian species: a literature review. Journal of Zoo and Wildlife Medicine, 37(3): 234-244.
    [35]
    Kalin NH, Shelton SE. 2003. Nonhuman primate models to study anxiety, emotion regulation, and psychopathology. Annals of the New York Academy of Sciences, 1008: 189-200.
    [36]
    Koolhaas JM, Korte SM, De Boer SF, Van Der Vegt BJ, Van Reenen CG, Hopster H, De Jong IC, Ruis MAW, Blokhuis HJ. 1999. Coping styles in animals: current status in behavior and stress-physiology. Neuroscience and Biobehavioral Reviews, 23(7): 925-936.
    [37]
    Liu CH, Tronick E. 2013. Rates and predictors of postpartum depression by race and ethnicity: Results from the 2004 to 2007 New York City PRAMS survey (Pregnancy Risk Assessment Monitoring System). Maternal and Child Health Journal, 17(9): 1599-1610.
    [38]
    Maestripieri D, Carroll KA. 2000. Causes and consequences of infant abuse and neglect in monkeys. Aggression and Violent Behavior, 5(3): 245-254.
    [39]
    McClure DJ. 1966. The diurnal variation of plasma cortisol levels in depression. Journal of Psychosomatic Research, 10(2): 189-195.
    [40]
    Michopoulos V, Higgins M, Toufexis D, Wilson ME. 2012. Social subordination produces distinct stress-related phenotypes in female rhesus monkeys. Psychoneuroendocrinology, 37(7): 1071-1085.
    [41]
    Millspaugh JJ, Washburn BE, Milanick MA, Beringer J, Hansen LP, Meyer TM. 2002. Non-invasive techniques for stress assessment in white-tailed deer. Wildlife Society Bulletin, 30(3): 899-907.
    [42]
    Nakamichi M. 2003. Age-related differences in social grooming among adult female Japanese monkeys (Macaca fuscata). Primates, 44(3): 239-246.
    [43]
    Nakamichi M, Cho F, Minami T. 1990. Mother-infant interactions of wild-born, individually-caged cynomolgus monkeys (Macaca fascicularis) during the first 14 weeks of infant life. Primates, 31(2): 213-224.
    [44]
    Nierop A, Bratsikas A, Zimmermann R, Ehlert U. 2006. Are stress-induced cortisol changes during pregnancy associated with postpartum depressive symptoms. Psychosomatic Medicine, 68(6): 931-937.
    [45]
    O'Hara MW. 1987. Post-partum ""blues,"" depression, and psychosis: A review. Journal of Psychosomatic Obstetrics and Gynecology, 7(3): 205-227.
    [46]
    O'Hara MW, Swain AM. 1996. Rates and risk of postpartum depression: a meta-analysis. International Review of Psychiatry, 8(1): 37-54.
    [47]
    O'Hara MW, McCabe JE. 2013. Postpartum depression: current status and future directions. Annual Review of Clinical Psychology, 9: 379-407.
    [48]
    Okano T, Nomura J. 1992. Endocrine study of the maternity blues. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 16(6): 921-932.
    [49]
    Osterlund MK. 2010. Underlying mechanisms mediating the antidepressant effects of estrogens. Biochimica et Biophysica Acta, 1800(10): 1136-1144.
    [50]
    Parker KJ, Schatzberg AF, Lyons DM. 2003. Neuroendocrine aspects of hypercortisolism in major depression. Hormones and Behavior, 43(1): 60-66.
    [51]
    Pryce CR, Dettling AC, Spengler M, Schnell CR, Feldon J. 2004. Deprivation of parenting disrupts development of homeostatic and reward systems in marmoset monkey offspring. Biological Psychiatry, 56(2): 72-79.
    [52]
    Russell E, Koren G, Rieder M, Van Uum S. 2012. Hair cortisol as a biological marker of chronic stress: Current status, future directions and unanswered questions. Psychoneuroendocrinology, 37(5): 589-601.
    [53]
    Sapolsky RM. 2005. The influence of social hierarchy on primate health. Science, 308(5722): 648-652.
    [54]
    Schüle C. 2007. Neuroendocrinological mechanisms of actions of antidepressant drugs. Journal of Neuroendocrinology, 19(3): 213-226.
    [55]
    Shively CA. 1998. Social subordination stress, behavior, and central monoaminergic function in female cynomolgus monkeys. Biological Psychiatry, 44(9): 882-891.
    [56]
    Shively CA, Laber-Laird K, Anton RF. 1997. Behavior and physiology of social stress and depression in female cynomolgus monkeys. Biological Psychiatry, 41(8): 871-882.
    [57]
    Shively CA, Williams JK, Laber-Laird K, Anton RF. 2002. Depression and coronary artery atherosclerosis and reactivity in female cynomolgus monkeys. Psychosomatic Medicine, 64(5): 699-706.
    [58]
    Shively CA, Register TC, Friedman DP, Morgan TM, Thompson J, Lanier T. 2005. Social stress-associated depression in adult female cynomolgus monkeys (Macaca fascicularis). Biological Psychology, 69(1): 67-84.
    [59]
    Shively CA, Friedman DP, Gage HD, Bounds MC, Brown-Proctor C, Blair JB, Henderson JA, Smith MA, Buchheimer N. 2006. Behavioral depression and positron emission tomography-determined serotonin 1A receptor binding potential in cynomolgus monkeys. Archives of General Psychiatry, 63(4): 396-403.
    [60]
    Shutt K, MacLarnon A, Heistermann M, Semple S. 2007. Grooming in Barbary macaques: better to give than to receive. Biology Letters, 3(3): 231-233.
    [61]
    Sibley CG, Ahlquist JE. 1987. DNA hybridization evidence of hominoid phylogeny: results from an expanded data set. Journal of Molecular Evolution, 26(1-2): 99-121.
    [62]
    Sit DK, Wisner KL. 2009. Identification of postpartum depression. Clinical Obstetrics and Gynecology, 52(3): 456-468.
    [63]
    Spitz RA, Wolf KA. 1946. Anaclitic depression: An inquiry into the genesis of psychiatric conditions in early childhood. The Psychoanalytic Study of the Child, 2: 313-342.
    [64]
    Stalder T, Steudte S, Alexander N, Miller R, Gao W, Dettenborn L, Kirschbaum C. 2012. Cortisol in hair, body mass index and stress-related measures. Biological Psychology, 90(3): 218-223.
    [65]
    Stoffel EC, Craft RM. 2004. Ovarian hormone withdrawal-induced ""depression"" in female rats. Physiology & Behavior, 83(3): 505-513.
    [66]
    Strome EM, Wheler GHT, Higley JD, Loriaux DL, Suomi SJ, Doudet DJ. 2002. Intracerebroventricular corticotropin-releasing factor increasees limbic glucose metabolism and has social context-dependent behavioral effects in nonhuman primates. Proceedings of the National Academy of Sciences of the United States of America, 99(24): 15749-15754.
    [67]
    Suda S, Segi-Nishida E, Newton SS, Duman RS. 2008. A postpartum model in rat: behavioral and gene expression changes induced by ovarian steroid deprivation. Biological Psychiatry, 64(4): 311-319.
    [68]
    Touma C, Palme R. 2005. Measuring fecal glucocorticoid metabolites in mammals and birds: the importance of validation. Annals of the New York Academy of Sciences, 1046: 54-74.
    [69]
    Tsuchida J, Yoshida T, Sankai T, Yasutomi Y. 2008. Maternal behavior of laboratory-born, individually reared long-tailed macaques (Macaca fascicularis). American Association for Laboratory Animal Science, 47(5): 29-34.
    [70]
    Van Esch E, Cline MJ, Buse E, Wood CE, De Rijk EPCT, Weinbauer GF. 2008. Summary comparison of female reproductive system in human and the cynomolgus monkey (Macaca fascicularis). Toxicologic Pathology, 36: 171S-172S.
    [71]
    Wennig R. 2000. Potential problems with the interpretation of hair analysis results. Forensic Science International, 107(1-3): 5-12.
    [72]
    Whitten PL, Stavisky R, Aureli F, Rusell E. 1998. Response of fecal cortisol to stress in captive chimpanzees (Pan troglodytes). American Journal of Primatology, 44(1): 57-69.
    [73]
    Willard SL, Shively CA. 2012. Modeling depression in adult female cynomolgus monkeys (Macaca fascicularis). American Journal of Primatology, 74(6): 528-542.
    [74]
    Willner P. 1991. Animal models as simulations of depression. Trends in Pharmacological Sciences, 12(4): 131-136.
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