[1] Adams JS, Hewison M. 2008. Unexpected actions of vitamin D: new perspectives on the regulation of innate and adaptive immunity. Nature Clinical Practice Endocrinology and Metabolism, 4(2): 80−90. doi:  10.1038/ncpendmet0716
[2] Ahmad Y, Sharma NK, Garg I, Ahmad MF, Sharma M, Bhargava K. 2013. An insight into the changes in human plasma proteome on adaptation to hypobaric hypoxia. PLoS One, 8(7): e67548. doi:  10.1371/journal.pone.0067548
[3] Ashburner M, Ball CA, Blake JA, Botstein D, Butler H, Cherry JM, Davis AP, Dolinski K, Dwight SS, Eppig JT, Harris MA, Hill DP, Issel-Tarver L, Kasarskis A, Lewis S, Matese JC, Richardson JE, Ringwald M, Rubin GM, Sherlock G. 2000. Gene Ontology: tool for the unification of biology. Nature Genetics, 25(1): 25−29. doi:  10.1038/75556
[4] Bärtsch P, Swenson ER. 2013. Acute high-altitude illnesses. The New England Journal of Medicine, 368(24): 2294−2302. doi:  10.1056/NEJMcp1214870
[5] Basnyat B, Murdoch DR. 2003. High-altitude illness. The Lancet, 361(9373): 1967−1974. doi:  10.1016/S0140-6736(03)13591-X
[6] Basu M, Pal K, Prasad R, Malhotra AS, Rao KS, Sawhney RC. 1997. Pituitary, gonadal and adrenal hormones after prolonged residence at extreme altitude in man. International Journal of Andrology, 20(3): 153−158. doi:  10.1046/j.1365-2605.1997.00046.x
[7] Benjamini Y, Hochberg Y. 1995. Controlling the false discovery rate: a practical and powerful approach to multiple testing. Journal of the Royal Statistical Society: Series B (Methodological), 57(1): 289−300. doi:  10.1111/j.2517-6161.1995.tb02031.x
[8] Berglund B. 1992. High-altitude training. Sports Medicine, 14(5): 289−303. doi:  10.2165/00007256-199214050-00002
[9] Bergmeier W, Piffath CL, Goerge T, Cifuni SM, Ruggeri ZM, Ware J, Wagner DD. 2006. The role of platelet adhesion receptor GPIbα far exceeds that of its main ligand, von Willebrand factor, in arterial thrombosis. Proceedings of the National Academy of Sciences of the United States of America, 103(45): 16900−16905. doi:  10.1073/pnas.0608207103
[10] Chen J, Leng T, Chen W, Yan M, Yin W, Huang Y, Lin S, Duan D, Lin J, Wu G, Zhang J, Yan G. 2013a. A Synthetic steroid 5α -androst-3β, 5, 6β -triol blocks hypoxia/reoxygenation-induced neuronal injuries via protection of mitochondrial function. Steroids, 78(10): 996−1002. doi:  10.1016/j.steroids.2013.06.004
[11] Chen L, Qiu J-H, Zhang L-L, Luo XD. 2012. Adrenomedullin promotes human endothelial cell proliferation via HIF-1α. Molecular and Cellular Biochemistry, 365(1–2): 263−273.
[12] Chen Y, Zhang J, Ge X, Du J, Deb DK, Li YC. 2013b. Vitamin D receptor inhibits nuclear factor κB activation by interacting with IκB kinase β protein. The Journal of Biological Chemistry, 288(27): 19450−19458. doi:  10.1074/jbc.M113.467670
[13] Chung I, Han G, Seshadri M, Gillard BM, Yu WD, Foster BA, Trump DL, Johnson CS. 2009. Role of vitamin D receptor in the antiproliferative effects of calcitriol in tumor-derived endothelial cells and tumor angiogenesis in vivo. Cancer Research, 69(3): 967−975. doi:  10.1158/0008-5472.CAN-08-2307
[14] Dunlop EA, Tee AR. 2014. mTOR and autophagy: a dynamic relationship governed by nutrients and energy. Seminars in Cell & Developmental Biology, 36(5): 121−129.
[15] Eyries M, Siegfried G, Ciumas M, Montagne K, Agrapart M, Lebrin F, Soubrier F. 2008. Hypoxia-induced apelin expression regulates endothelial cell proliferation and regenerative angiogenesis. Circulation Research, 103(4): 432−440. doi:  10.1161/CIRCRESAHA.108.179333
[16] Gemmati D, Vigliano M, Burini F, Mari R, El Mohsein HH, Parmeggiani F, Serino ML. 2016. Coagulation factor XIIIA (F13A1): novel perspectives in treatment and pharmacogenetics. Current Pharmaceutical Design, 22(11): 1449−1459. doi:  10.2174/1381612822666151210122954
[17] Giffard RG, Xu L, Zhao H, Carrico W, Ouyang Y, Qiao Y, Sapolsky R, Steinberg G, Hu B, Yenari MA. 2004. Chaperones, protein aggregation, and brain protection from hypoxic/ischemic injury. Journal of Experimental Biology, 207(18): 3213−3220. doi:  10.1242/jeb.01034
[18] Guo P, Luo H, Fan Y, Luo Y, Zhou Q. 2013. Establishment and evaluation of an experimental animal model of high altitude cerebral edema. Neuroscience Letters, 547: 82−86. doi:  10.1016/j.neulet.2013.05.008
[19] Hackett PH, Roach RC. 2004. High altitude cerebral edema. High Altitude Medicine & Biology, 5(2): 136−146.
[20] Han S, Xu W, Wang Z, Qi X, Wang Y, Ni Y, Shen H, Hu Q, Han W. 2016. Crosstalk between the HIF-1 and Toll-like receptor/nuclear factor- κB pathways in the oral squamous cell carcinoma microenvironment. Oncotarget, 7(25): 37773−37789.
[21] Hasegawa T, Yoshida S, Sugeno N, Kobayashi J, Aoki M. 2018. DnaJ/Hsp40 family and Parkinson’ s disease. Frontiers in Neuroscience, 11: 743. doi:  10.3389/fnins.2017.00743
[22] Hatfield KJ, Bedringsaas SL, Ryningen A, Gjertsen BT, Bruserud O. 2010. Hypoxia increases HIF-1α expression and constitutive cytokine release by primary human acute myeloid leukaemia cells. European Cytokine Network, 21(3): 154−164.
[23] Hu H, Zhou Y, Leng T, Liu A, Wang Y, You X, Chen J, Tang L, Chen W, Qiu P, Yin W, Huang Y, Zhang J, Wang L, Sang H, Yan G. 2014. The major cholesterol metabolite cholestane-3β, 5α, 6β -triol functions as an endogenous neuroprotectant. Journal of Neuroscience, 34(34): 11426−11438. doi:  10.1523/JNEUROSCI.0344-14.2014
[24] Huang X, Zhou Y, Zhao T, Han X, Qiao M, Ding X, Li D, Wu L, Wu K, Zhu LL, Fan M. 2015. A method for establishing the high-altitude cerebral edema (HACE) model by acute hypobaric hypoxia in adult mice. Journal of Neuroscience Methods, 245: 178−181. doi:  10.1016/j.jneumeth.2015.02.004
[25] Ikegame Y, Yamashita K, Hayashi S, Yoshimura S, Nakashima S, Iwama T. 2010. Neutrophil elastase inhibitor prevents ischemic brain damage via reduction of vasogenic edema. Hypertension Research, 33(7): 703−707. doi:  10.1038/hr.2010.58
[26] Imray C, Wright A, Subudhi A, Roach R. 2010. Acute mountain sickness: pathophysiology, prevention, and treatment. Progress in Cardiovascular Diseases, 52(6): 467−484. doi:  10.1016/j.pcad.2010.02.003
[27] Jain K, Suryakumar G, Ganju L, Singh SB. 2014. Differential hypoxic tolerance is mediated by activation of heat shock response and nitric oxide pathway. Cell Stress Chaperones, 19(6): 801−812. doi:  10.1007/s12192-014-0504-9
[28] Jung YJ, Isaacs JS, Lee S, Trepel J, Neckers L. 2003. IL-1β mediated up-regulation of HIF-1α via an NFkB/COX-2 pathway identifies HIF-1 as a critical link between inflammation and oncogenesis. The FASEB Journal, 17(14): 2115−2117. doi:  10.1096/fj.03-0329fje
[29] Kanehisa M, Goto S. 2000. KEGG: kyoto encyclopedia of genes and genomes. Nucleic Acids Research, 28(1): 27−30. doi:  10.1093/nar/28.1.27
[30] Kato S. 2000. The function of vitamin D receptor in vitamin D action. The Journal Biochemistry, 127(5): 717−722. doi:  10.1093/oxfordjournals.jbchem.a022662
[31] Kilkenny C, Browne WJ, Cuthill IC, Emerson M, Altman DG. 2010. Improving bioscience research reporting: the ARRIVE guidelines for reporting animal research. PLoS Biology, 8(6): e1000412. doi:  10.1371/journal.pbio.1000412
[32] Kim D, Langmead B, Salzberg SL. 2015. HISAT: a fast spliced aligner with low memory requirements. Nature Methods, 12(4): 357−360. doi:  10.1038/nmeth.3317
[33] Kimmel HL, Thim L, Kuhar MJ. 2002. Activity of various CART peptides in changing locomotor activity in the rat. Neuropeptides, 36(1): 9−12. doi:  10.1054/npep.2002.0884
[34] Kito G, Nishimura A, Susumu T, Nagata R, Kuge Y, Yokota C, Minematsu K. 2001. Experimental thromboembolic stroke in cynomolgus monkey. Journal Neuroscience Methods, 105(1): 45−53. doi:  10.1016/S0165-0270(00)00351-4
[35] Lambert PD, Couceyro PR, Mcgirr KM, Dall Vechia SE, Smith Y, Kuhar MJ. 1998. CART peptides in the central control of feeding and interactions with neuropeptide Y. Synapse, 29(4): 293−298. doi:  10.1002/(SICI)1098-2396(199808)29:4<293::AID-SYN1>3.0.CO;2-0
[36] Langfelder P, Horvath S. 2008. WGCNA: an R package for weighted correlation network analysis. BMC Bioinformatics, 9(1): 559. doi:  10.1186/1471-2105-9-559
[37] Leek JT, Scharpf RB, Bravo HC, Simcha D, Langmead B, Johnson WE, Geman D, Baggerly K, Irizarry RA. 2010. Tackling the widespread and critical impact of batch effects in high-throughput data. Nature Reviews Genetics, 11(10): 733−739. doi:  10.1038/nrg2825
[38] Lissa V-A, Bruno M, Suzana H-H. 2013. Different scaling of white matter volume, cortical connectivity, and gyrification across rodent and primate brains. Frontiers in Neuroanatomy, 7(3).
[39] Liu YW, Li S, Dai SS. 2018. Neutrophils in traumatic brain injury (TBI): friend or foe?. Journal of Neuroinflammation, 15(1): 146. doi:  10.1186/s12974-018-1173-x
[40] Love MI, Huber W, Anders S. 2014. Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biology, 15(12): 550. doi:  10.1186/s13059-014-0550-8
[41] Martin D, Windsor J. 2008. From mountain to bedside: understanding the clinical relevance of human acclimatisation to high-altitude hypoxia. Postgraduate Medical Journal, 84(998): 622−627. doi:  10.1136/pgmj.2008.068296
[42] Minta A, Kao JP, Tsien RY. 1989. Fluorescent indicators for cytosolic calcium based on rhodamine and fluorescein chromophores. The Journal of Biological Chemistry, 264(14): 8171−8178.
[43] Moriya Y, Itoh M, Okuda S, Yoshizawa AC, Kanehisa M. 2007. KAAS: an automatic genome annotation and pathway reconstruction server. Nucleic Acids Research, 35(suppl_2): W182−W185.
[44] Nei M, Xu P, Glazko G. 2001. Estimation of divergence times from multiprotein sequences for a few mammalian species and several distantly related organisms. Proceedings of the National Academy of Sciences of the United States of America, 98(5): 2497−2502. doi:  10.1073/pnas.051611498
[45] Palazon A, Goldrath AW, Nizet V, Johnson RS. 2014. HIF transcription factors, inflammation, and immunity. Immunity, 41(4): 518−528. doi:  10.1016/j.immuni.2014.09.008
[46] Qiu XB, Shao YM, Miao S, Wang L. 2006. The diversity of the DnaJ/Hsp40 family, the crucial partners for Hsp70 chaperones. Cellular and Molecular Life Sciences, 63(22): 2560−2570. doi:  10.1007/s00018-006-6192-6
[47] Rabinstein AA. 2006. Treatment of cerebral edema. The Neurologist, 12(2): 59−73. doi:  10.1097/01.nrl.0000186810.62736.f0
[48] Ramakrishnan S, Anand V, Roy S. 2014. Vascular endothelial growth factor signaling in hypoxia and inflammation. Journal of Neuroimmune Pharmacology, 9(2): 142−160. doi:  10.1007/s11481-014-9531-7
[49] Ravenna L, Salvatori L, Russo MA. 2015. HIF3a: the little we know. The FEBS Journal, 283(6): 993−1003.
[50] Robinson MD, Mccarthy DJ, Smyth GK. 2010. edgeR: a Bioconductor package for differential expression analysis of digital gene expression data. Bioinformatics, 26(1): 139−140. doi:  10.1093/bioinformatics/btp616
[51] Rogge G, Jones D, Hubert GW, Lin Y, Kuhar MJ. 2008. CART peptides: regulators of body weight, reward and other functions. Nature Reviews Neuroscience, 9(10): 747−758. doi:  10.1038/nrn2493
[52] Saha D, Patgaonkar M, Shroff A, Ayyar K, Bashir T, Reddy KVR. 2014. Hemoglobin expression in nonerythroid cells: novel or ubiquitous?. International Journal of Inflammation, 2014.
[53] Scannevin RH, Huganir RL. 2000. Postsynaptic organisation and regulation of excitatory synapses. Nature Reviews Neuroscience, 1(2): 133−141. doi:  10.1038/35039075
[54] Schoch HJ, Fischer S, Marti HH. 2002. Hypoxia - induced vascular endothelial growth factor expression causes vascular leakage in the brain. Brain, 125(11): 2549−2557. doi:  10.1093/brain/awf257
[55] Semenza GL. 2009. Regulation of oxygen homeostasis by hypoxia-inducible factor 1. Physiology, 24(2): 97−106. doi:  10.1152/physiol.00045.2008
[56] Simonson TS, Yang Y, Huff CD, Yun H, Qin G, Witherspoon DJ, Bai Z, Lorenzo FR, Xing J, Jorde LB. 2010. Genetic evidence for high-altitude adaptation in Tibet. Science, 329(5987): 72−75. doi:  10.1126/science.1189406
[57] Singh M, Su C. 2013. Progesterone and neuroprotection. Hormones and Behavior, 63(2): 284−290. doi:  10.1016/j.yhbeh.2012.06.003
[58] Soto C, Estrada LD. 2008. Protein misfolding and neurodegeneration. Archives of Neurology & Psychiatry, 65(2): 184−189.
[59] Sparkenbaugh E, Pawlinski R. 2013. Interplay between coagulation and vascular inflammation in sickle cell disease. British Journal of Haematology, 162(1): 3−14. doi:  10.1111/bjh.12336
[60] Stamatovic SM, Dimitrijevic OB, Keep RF, Andjelkovic AV. 2006. Inflammation and brain edema: new insights into the role of chemokines and their receptors. Acta Neurochirurgical Supplementum, 96: 444.
[61] Stein DG. 2008. Progesterone exerts neuroprotective effects after brain injury. Brain Research Reviews, 57(2): 386−397. doi:  10.1016/j.brainresrev.2007.06.012
[62] Trapnell C, Hendrickson DG, Sauvageau M, Goff L, Rinn JL, Pachter L. 2013. Differential analysis of gene regulation at transcript resolution with RNA-seq. Nature Biotechnology, 31(1): 46−53. doi:  10.1038/nbt.2450
[63] Ward Jr JH. 1963. Hierarchical grouping to optimize an objective function. Journal of the American Statistical Association, 58(301): 236−244. doi:  10.1080/01621459.1963.10500845
[64] Wilson MH, Newman S, Imray CH. 2009. The cerebral effects of ascent to high altitudes. The Lancet Neurology, 8(2): 175−191. doi:  10.1016/S1474-4422(09)70014-6
[65] Won S, Sayeed I, Peterson BL, Wali B, Kahn JS, Stein DG. 2015. Vitamin D prevents hypoxia/reoxygenation-induced blood-brain barrier disruption via Vitamin D receptor-mediated NF-kB signaling pathways. PLoS One, 10(3): e0122821. doi:  10.1371/journal.pone.0122821
[66] Wright AD, Beazley MF, Bradwell AR, Chesner IM, Clayton RN, Forster PJ, Hillenbrand P, Imray CH, Society BMRE. 2004. Medroxyprogesterone at high altitude. The effects on blood gases, cerebral regional oxygenation, and acute mountain sickness. Wilderness & Environmental Medicine, 15(1): 25−31.
[67] Wroge CM, Hogins J, Eisenman L, Mennerick S. 2012. Synaptic NMDA receptors mediate hypoxic excitotoxic death. Journal of Neuroscience, 32(19): 6732−6742. doi:  10.1523/JNEUROSCI.6371-11.2012
[68] Yan G, Zhang G, Fang X, Zhang Y, Li C, Ling F, Cooper DN, Li Q, Li Y, Van Gool AJ, Du H, Chen J, Zhang P, Huang Z, Thompson JR, Meng Y, Bai Y, Wang J, Zhuo M, Wang T, Huang Y, Wei L, Li J, Wang Z, Hu H, Yang P, Le L, Stenson PD, Li B, Liu X, Ball EV, An N, Huang Q, Zhang Y, Fan W, Zhang X, Li Y, Wang W, Katze MG, Su B, Nielsen R, Yang H, Wang J, Wang X, Wang J. 2011. Genome sequencing and comparison of two non-human primate animal models, the cynomolgus and Chinese rhesus macaques. Nature Biotechnology, 29(11): 1019−1023. doi:  10.1038/nbt.1992
[69] Yi X, Liang Y, Huerta-Sanchez E, Jin X, Cuo ZXP, Pool JE, Xu X, Jiang H, Vinckenbosch N, Korneliussen TS, Zheng H, Liu T, He W, Li K, Luo R, Nie X, Wu H, Zhao M, Cao H, Zou J, Shan Y, Li S, Yang Q, As an, Ni P, Tian G, Xu J, Liu X, Jiang T, Wu R, Zhou G, Tang M, Qin J, Wang T, Feng S, Li G, Huasang, Luosang J, Wang W, Chen F, Wang Y, Zheng X, Li Z, Bianba Z, Yang G, Wang X, Tang S, Gao G, Chen Y, Luo Z, Gusang L, Cao Z, Zhang Q, Ouyang W, Ren X, Liang H, Zheng H, Huang Y, Li J, Bolund L, Kristiansen K, Li Y, Zhang Y, Zhang X, Li R, Li S, Yang H, Nielsen R, Wang J, Wang J. 2010. Sequencing of 50 human exomes reveals adaptation to high altitude. Science, 329(5987): 75−78. doi:  10.1126/science.1190371