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Chaochao Yan, Xinshang Zhang, Liang Zhou, Qiao Yang, Min Zhou, Linwan Zhang, Jinchuan Xing, Zhifeng Yan, Megan Price, Jing Li, Bisong Yue, Zhenxin Fan. Effects of aging on gene expression in the blood of captive Tibetan Macaques (Macaca thibetana) and comparisons with expressions in humans. Zoological Research. doi: 10.24272/j.issn.2095-8137.2020.092
Citation: Chaochao Yan, Xinshang Zhang, Liang Zhou, Qiao Yang, Min Zhou, Linwan Zhang, Jinchuan Xing, Zhifeng Yan, Megan Price, Jing Li, Bisong Yue, Zhenxin Fan. Effects of aging on gene expression in the blood of captive Tibetan Macaques (Macaca thibetana) and comparisons with expressions in humans. Zoological Research. doi: 10.24272/j.issn.2095-8137.2020.092

Effects of aging on gene expression in the blood of captive Tibetan Macaques (Macaca thibetana) and comparisons with expressions in humans

doi: 10.24272/j.issn.2095-8137.2020.092
Funds:  This work was supported by the National Natural Science Foundation of China 31501871 (Z. Fan), Department of Science and Technology of Sichuan Province 2019JDZH0029 (X. Zhang), Department of Science and Technology of Sichuan Province 2020JDZH0026 (X. Zhang) and Academy of Medical Sciences & Sichuan Provincial People’s Hospital 2017QN06 (X. Zhang).
  • Received Date: 2020-04-23
  • Accepted Date: 2020-06-18
  • Rev Recd Date: 2020-06-17
  • Available Online: 2020-06-24
  • Aging is an essential factor affecting metabolic activities and disease resistance. The macaques have been used as a model species for primate evolutionary and biomedical studies. To study the gene expression in the Macaca thibetana (TM) and to clarify its differences to humans, we applied RNA-Seq to determine blood transcriptomes from 24 TMs. A total of 2,523 age-related differentially expressed genes (DEGs) were identified, and two significant age-related gene modules were identified by co-expression analysis. Some age-related pathways, such as the FoxO signaling pathway was significantly enriched by up-regulated DEGs and positively age-related core genes. There were shared 279 common DEGs, including 111 up-regulated, 141 down-regulated and 27 DEGs with different directions between TMs and humans. Our study suggests that aging is a critical factor affecting gene expression in TMs. The findings of the similarity and difference of gene expression profiles between TMs and humans could provide new insights into primate evolution and benefit the biomedical research about TM.
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    沈阳化工大学材料科学与工程学院 沈阳 110142

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Effects of aging on gene expression in the blood of captive Tibetan Macaques (Macaca thibetana) and comparisons with expressions in humans

doi: 10.24272/j.issn.2095-8137.2020.092
Funds:  This work was supported by the National Natural Science Foundation of China 31501871 (Z. Fan), Department of Science and Technology of Sichuan Province 2019JDZH0029 (X. Zhang), Department of Science and Technology of Sichuan Province 2020JDZH0026 (X. Zhang) and Academy of Medical Sciences & Sichuan Provincial People’s Hospital 2017QN06 (X. Zhang).

Abstract: Aging is an essential factor affecting metabolic activities and disease resistance. The macaques have been used as a model species for primate evolutionary and biomedical studies. To study the gene expression in the Macaca thibetana (TM) and to clarify its differences to humans, we applied RNA-Seq to determine blood transcriptomes from 24 TMs. A total of 2,523 age-related differentially expressed genes (DEGs) were identified, and two significant age-related gene modules were identified by co-expression analysis. Some age-related pathways, such as the FoxO signaling pathway was significantly enriched by up-regulated DEGs and positively age-related core genes. There were shared 279 common DEGs, including 111 up-regulated, 141 down-regulated and 27 DEGs with different directions between TMs and humans. Our study suggests that aging is a critical factor affecting gene expression in TMs. The findings of the similarity and difference of gene expression profiles between TMs and humans could provide new insights into primate evolution and benefit the biomedical research about TM.

Chaochao Yan, Xinshang Zhang, Liang Zhou, Qiao Yang, Min Zhou, Linwan Zhang, Jinchuan Xing, Zhifeng Yan, Megan Price, Jing Li, Bisong Yue, Zhenxin Fan. Effects of aging on gene expression in the blood of captive Tibetan Macaques (Macaca thibetana) and comparisons with expressions in humans. Zoological Research. doi: 10.24272/j.issn.2095-8137.2020.092
Citation: Chaochao Yan, Xinshang Zhang, Liang Zhou, Qiao Yang, Min Zhou, Linwan Zhang, Jinchuan Xing, Zhifeng Yan, Megan Price, Jing Li, Bisong Yue, Zhenxin Fan. Effects of aging on gene expression in the blood of captive Tibetan Macaques (Macaca thibetana) and comparisons with expressions in humans. Zoological Research. doi: 10.24272/j.issn.2095-8137.2020.092
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