Effects of aging on gene expression in the blood of captive Tibetan Macaques (Macaca thibetana) and comparisons with expressions in humans
- Received Date: 2020-04-23
- Accepted Date: 2020-06-18
- Rev Recd Date: 2020-06-17
- Available Online: 2020-06-24
Abstract: Aging is an essential factor affecting metabolic activities and disease resistance. The macaques have been used as a model species for primate evolutionary and biomedical studies. To study the gene expression in the Macaca thibetana (TM) and to clarify its differences to humans, we applied RNA-Seq to determine blood transcriptomes from 24 TMs. A total of 2,523 age-related differentially expressed genes (DEGs) were identified, and two significant age-related gene modules were identified by co-expression analysis. Some age-related pathways, such as the FoxO signaling pathway was significantly enriched by up-regulated DEGs and positively age-related core genes. There were shared 279 common DEGs, including 111 up-regulated, 141 down-regulated and 27 DEGs with different directions between TMs and humans. Our study suggests that aging is a critical factor affecting gene expression in TMs. The findings of the similarity and difference of gene expression profiles between TMs and humans could provide new insights into primate evolution and benefit the biomedical research about TM.
|Citation:||Chaochao Yan, Xinshang Zhang, Liang Zhou, Qiao Yang, Min Zhou, Linwan Zhang, Jinchuan Xing, Zhifeng Yan, Megan Price, Jing Li, Bisong Yue, Zhenxin Fan. Effects of aging on gene expression in the blood of captive Tibetan Macaques (Macaca thibetana) and comparisons with expressions in humans. Zoological Research. doi: 10.24272/j.issn.2095-8137.2020.092|