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Yue Lan, Jiao Wang, Qiao Yang, Ruixiang Tang, Min Zhou, Guanglun Lei, Jing Li, Liang Zhang, Bisong Yue, Zhenxin Fan. Blood transcriptome analysis reveals the gene expression features of breast-feeding period infants in rhesus macaque (Macaca mulatta)[J]. Zoological Research. doi: 10.24272/j.issn.2095-8137.2020.044
Citation: Yue Lan, Jiao Wang, Qiao Yang, Ruixiang Tang, Min Zhou, Guanglun Lei, Jing Li, Liang Zhang, Bisong Yue, Zhenxin Fan. Blood transcriptome analysis reveals the gene expression features of breast-feeding period infants in rhesus macaque (Macaca mulatta)[J]. Zoological Research. doi: 10.24272/j.issn.2095-8137.2020.044

Blood transcriptome analysis reveals the gene expression features of breast-feeding period infants in rhesus macaque (Macaca mulatta)

doi: 10.24272/j.issn.2095-8137.2020.044
Funds:  This work was supported by the National Natural Science Foundation of China (31501871) and Chengdu giant panda breeding research foundation (CPF2017-19).
  • Received Date: 2020-02-29
  • Accepted Date: 2020-05-07
  • Rev Recd Date: 2020-05-07
  • Available Online: 2020-05-13
  • The infants during the breast-feeding period are underwent physiological and developmental remarkable changes. However, little is known about the gene expression features and the sex-specific gene expression of breast-feeding period infants. In this study, we sequenced 32 blood transcriptomes from 16 breast-feeding period infants of rhesus macaque (Macaca mulatta) and their lactating mothers. We identified 218 differentially expressed genes (DEGs) between infants and their mothers, including 91 up-regulated and 127 down-regulated DEGs in the infant group. Functional enrichment analysis with up-regulated DEGs or unique hub genes in infants both were mainly enriched in immune, growth and development. The protein-protein interaction analysis also revealed that genes at the key positions in infants were mainly related to development and immunity. However, we only detected 23 DEGs between female and male infants, including two DEGs located on Chromosome X and 11 DEGs located on Chromosome Y. One of the 23 DEGs was TMF1 regulated nuclear protein 1 (Trnp1), which was highly expressed in the female infants, was crucial to control the tangential and radial expansion of the cerebral cortex in mammals. Our study provides novel insights into the gene expression features of breast-feeding period infants in non-human primate, and also reveals the sex-specific gene expression between these infants.
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    沈阳化工大学材料科学与工程学院 沈阳 110142

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Blood transcriptome analysis reveals the gene expression features of breast-feeding period infants in rhesus macaque (Macaca mulatta)

doi: 10.24272/j.issn.2095-8137.2020.044
Funds:  This work was supported by the National Natural Science Foundation of China (31501871) and Chengdu giant panda breeding research foundation (CPF2017-19).

Abstract: The infants during the breast-feeding period are underwent physiological and developmental remarkable changes. However, little is known about the gene expression features and the sex-specific gene expression of breast-feeding period infants. In this study, we sequenced 32 blood transcriptomes from 16 breast-feeding period infants of rhesus macaque (Macaca mulatta) and their lactating mothers. We identified 218 differentially expressed genes (DEGs) between infants and their mothers, including 91 up-regulated and 127 down-regulated DEGs in the infant group. Functional enrichment analysis with up-regulated DEGs or unique hub genes in infants both were mainly enriched in immune, growth and development. The protein-protein interaction analysis also revealed that genes at the key positions in infants were mainly related to development and immunity. However, we only detected 23 DEGs between female and male infants, including two DEGs located on Chromosome X and 11 DEGs located on Chromosome Y. One of the 23 DEGs was TMF1 regulated nuclear protein 1 (Trnp1), which was highly expressed in the female infants, was crucial to control the tangential and radial expansion of the cerebral cortex in mammals. Our study provides novel insights into the gene expression features of breast-feeding period infants in non-human primate, and also reveals the sex-specific gene expression between these infants.

Yue Lan, Jiao Wang, Qiao Yang, Ruixiang Tang, Min Zhou, Guanglun Lei, Jing Li, Liang Zhang, Bisong Yue, Zhenxin Fan. Blood transcriptome analysis reveals the gene expression features of breast-feeding period infants in rhesus macaque (Macaca mulatta)[J]. Zoological Research. doi: 10.24272/j.issn.2095-8137.2020.044
Citation: Yue Lan, Jiao Wang, Qiao Yang, Ruixiang Tang, Min Zhou, Guanglun Lei, Jing Li, Liang Zhang, Bisong Yue, Zhenxin Fan. Blood transcriptome analysis reveals the gene expression features of breast-feeding period infants in rhesus macaque (Macaca mulatta)[J]. Zoological Research. doi: 10.24272/j.issn.2095-8137.2020.044
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