Volume 32 Issue 6
Nov.  2011
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MAO Yu, YANG Shang-Chuan, LIU Chang, MA Yuan-Ye, HU Xin-Tian. Effects of propranolol on acquisition and retrieval of morphine- induced conditioned place preference memories in ICR mice. Zoological Research, 2011, 32(6): 670-674. doi: 10.3724/SP.J.1141.2011.06670
Citation: MAO Yu, YANG Shang-Chuan, LIU Chang, MA Yuan-Ye, HU Xin-Tian. Effects of propranolol on acquisition and retrieval of morphine- induced conditioned place preference memories in ICR mice. Zoological Research, 2011, 32(6): 670-674. doi: 10.3724/SP.J.1141.2011.06670

Effects of propranolol on acquisition and retrieval of morphine- induced conditioned place preference memories in ICR mice

doi: 10.3724/SP.J.1141.2011.06670
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  • Author Bio:

    MAO Yu,YANG Shang-Chuan

    MAO Yu,YANG Shang-Chuan

  • Corresponding author: MA Yuan-Ye,HU Xin-Tian
  • Received Date: 2011-05-03
  • Rev Recd Date: 2011-10-31
  • Publish Date: 2011-12-22
  • To interfere with the drug-cue memory processes of addicts such as reconsolidation by the administration of the β-adrenergic receptor (β-AR) of norepinephrine (NE) antagonist propranolol (PRO) has become a potential therapy in the future to decrease or inhibit relapse. However, the relationship between PRO and the acquisition or retrieval of morphine-cue memory is not clear.This study examined the effects of PRO on the acquisition and retrieval of memories in morphine-induced conditioned place preference (CPP) mice model. We found that during memory acquisition period, PRO had no effects on the expression and extinction of morphine-CPP, which suggests that the β-AR was irrelevant to the CPP memory acqusition. However, during memoery retrival period, although PRO did not affect the expression of CPP, but it delayed the occurrence of CPP extinction, which indicates that PRO has an inhibit effect on CPP memery extinction, and β-AR plays an important role in modulating the extinction of morphine-CPP. Our study further improved the relationship between drug addiction and β-AR, and proposed a new theory to help developing potential therapy to cure addiction and other neuropsychiatric disorders.
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