Founding of Object Recognition Learning Paradigm in KM Mice and Its Application in Detecting Memory Impaired Properties of Compounds

The aim of the present study was to found the object recognition learning paradigm in KM mice and evaluate the potential usefulness of the object recognition learning paradigm in safety pharmacology. The time dependent decay of object recognition memory was characterized in KM mice. Memory retention was tested 4 h or 1 h after training in KM mice. The impairment of scopolamine on the object recognition memory was assessed in KM mice. Results show that the object recognition task can easily be performed and scopolamine impairs the object recognition memory in KM mice. The object recognition task in KM mice, which is simple, rapid, and reliable, should be of great use in safety pharmacology to detect amnesic properties of new compounds.