Inhibition of DNA Repair Ability of Human Esophageal Cancer Cell and CHO-K1 Cell by Hyperthermia

CHEN Que; ZHOU Qi-lin; JIA Xian-li ZHENG De-cun

CHEN Que, ZHOU Qi-lin, JIA Xian-li ZHENG De-cun. 1984. Inhibition of DNA Repair Ability of Human Esophageal Cancer Cell and CHO-K1 Cell by Hyperthermia. Zoological Research, 5(3): 227-232.

Citation:

CHEN Que, ZHOU Qi-lin, JIA Xian-li ZHENG De-cun. 1984. Inhibition of DNA Repair Ability of Human Esophageal Cancer Cell and CHO-K1 Cell by Hyperthermia. Zoological Research, 5(3): 227-232.

Citation:

CHEN Que, ZHOU Qi-lin, JIA Xian-li ZHENG De-cun. 1984. Inhibition of DNA Repair Ability of Human Esophageal Cancer Cell and CHO-K1 Cell by Hyperthermia. Zoological Research, 5(3): 227-232.

Inhibition of DNA Repair Ability of Human Esophageal Cancer Cell and CHO-K1 Cell by Hyperthermia

Graphical Abstract

Abstract

Abstract

Suspension samples of human esophageal cancer cell strain Eca-109 Were treated,before or after 8,000 rad 60 Co γ-irradiation,with 44° or 42℃ for 30 minutes and then incubated in growth medium at 37℃ for 1.5 hours.The 44° treatment inhibited the DNA rejoining repair completely.The 42℃ treatment inhibited it by about 60%,and the uninhibited portion could be repaired during the 42°treatment after irradiation.The suspension samples of CHO-K1 cell were treated,before UV-irradiation (about 50 J/M2),with 44°or 42℃ for 30 minutes and then incubated in growth medium containing 3H-TdR (1μCi/ml) at 37℃ for 3 hours.The 44°treatment inhibited the DNA excision repair completely.The 42°treatment inhibited it incompletely.