CONG Ying-zi, YU Shi-guang. 1994. Regulation of Surface IgD Expression on Murine B Cells. Zoological Research, 15(3): 81-86.
Citation: CONG Ying-zi, YU Shi-guang. 1994. Regulation of Surface IgD Expression on Murine B Cells. Zoological Research, 15(3): 81-86.

Regulation of Surface IgD Expression on Murine B Cells

  • The expression of surface IgD on murine splenic B cells and the regulation of sIgD expression by different stimuli were studied in this paper.The results demonstrated that splenic B cells form two major populations.The high-density small splenic B cells have the phenotype of sIgDhigh and sIgDlow B cells fall into low-density large population.Activation of resting B cells with LPS and anti-IgM induces differences in the level of IgD.Stimulation of resting B cells with LPS decreases the level of sIgD,but sIgD remains high after anti-IgM stimulation.Additional stimulation of Ril-6 following anti-IgM stimulation can lead to decrease the level of sIgD.Taking those together,we conclude that the expression of sIgD goes down following B cell activation.
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