Lei Shi, Bing Su. 2019. A transgenic monkey model for the study of human brain evolution. Zoological Research, 40(3): 236-238. DOI: 10.24272/j.issn.2095-8137.2019.031
Citation: Lei Shi, Bing Su. 2019. A transgenic monkey model for the study of human brain evolution. Zoological Research, 40(3): 236-238. DOI: 10.24272/j.issn.2095-8137.2019.031

A transgenic monkey model for the study of human brain evolution

  • Why humans have large brains with higher cognitive abilities is a question long asked by scientists. However, much remains unknown, especially the underlying genetic mechanisms. With the use of a transgenic monkey model, we showed that human-specific sequence changes of a key brain development gene (primary microcephaly1, MCPH1) could result in detectable molecular and cognitive changes resembling human neoteny, a notable characteristic developed during human evolution.
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