恒河猕猴吗啡成瘾模型的初步建立
Morphine addiction in non-human primates using rhesus monkeys
-
摘要: 吗啡成瘾的非人灵长类动物恒河猕猴(Macaca mulatta)模型的实验结果表明, 猕猴可建立吗啡条件化位置偏好(conditioned place preference, CPP), 且其与吗啡线索相关的记忆可持续(36.3±1.3)月。该研究可以为药物成瘾研究提供有效的非人灵长类动物行为模型。Abstract: We showed that rhesus monkeys (Macaca mulatta) can develop a morphine dependence. Rhesus monkeys successfully established a conditioned place preference (CPP) induced by morphine treatment and this preference lasted for at least (36.3±1.3) months. This animal model may be useful for research into addiction in humans.