乙型肝炎病毒树鼩体内慢性感染模型的研究历程和展望

Progress on establishment of tree shrew(Tupaia) chronic infection with HBV in vivo

摘要: 乙型肝炎病毒(HBV)感染是全球和我国的重要健康问题, 建立方便有效的HBV感染动物体内模型是开展HBV相关基础和临床研究的重要前提。该实验室地处乙型肝炎和肝癌高发流行的广西地区, 自建立以来一直以肝癌的病因、发病机制和化学预防作为主要研究方向, 于20世纪80年代初开始树鼩体内感染HBV模型方面的研究并持续至今。该文对此研究历程作一概述, 并重点介绍关于用新生树鼩慢性感染HBV的新进展。

Abstract: Hepatitis B virus (HBV) infection is one of the important health problems worldwide, especially in China. Feasible and effective animal models of HBV infection in vivo are prerequisite for the HBV-related basic and clinical studies. Located in the highly prevalent region of HBV and hepatocellular carcinoma (HCC), the laboratoryof Guangxi Cancer Institute has focused on the cause, pathogenesis and chemoprevention of HCC, and has started the work of establishing tree shrew (Tupaia) models of HBV infection in vivo since the early 1980s. This paper provides an overview of the research process, and highlights the new progress on the chronic infection of tree shrews after inoculated with HBV neonatally in vivo.