树鼩作为丙型肝炎动物模型的HCV受体研究进展
Progress in studies on HCV receptor of Tupaia as a potential hepatitis C animal model
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摘要: 丙型肝炎病毒(hepatitis C virus, HCV)全球流行、危害严重, 合适的小动物模型的缺乏严重阻碍了药物和疫苗的研发。该文介绍丙型肝炎危害与病毒复制特点, 以HCV入胞受体为重点, 通过比较现有丙型肝炎动物模型, 从分子水平探讨树鼩作为丙型肝炎动物模型的可能性。Abstract: Hepatitis C virus is a prevalent and globally distributed human pathogen that seriously harmful to public health. However, the development of therapy and vaccine was impeded by the lack of suit small animal models. Herein, we introduce the characters of HCV replication. Taken the HCV cellular receptors as the viewpoint, the potentiality of tupaia as hepatitis C animal model is discussed at the molecular level by comparing of present animal model.