• 中文核心期刊要目总览
  • 中国科技核心期刊
  • 中国科学引文数据库(CSCD)
  • 中国科技论文与引文数据库(CSTPCD)
  • 中国学术期刊文摘数据库(CSAD)
  • 中国学术期刊(网络版)(CNKI)
  • 中文科技期刊数据库
  • 万方数据知识服务平台
  • 中国超星期刊域出版平台
  • 国家科技学术期刊开放平台
  • 荷兰文摘与引文数据库(SCOPUS)
  • 日本科学技术振兴机构数据库(JST)
夏厚军, 陈策实. 2011: 非人灵长类肿瘤模型研究进展(英文). 动物学研究, 32(1): 70-80. DOI: 10.3724/SP.J.1141.2011.01070
引用本文: 夏厚军, 陈策实. 2011: 非人灵长类肿瘤模型研究进展(英文). 动物学研究, 32(1): 70-80. DOI: 10.3724/SP.J.1141.2011.01070
XIA Hou-Jun, CHEN Ce-Shi. 2011: Progress of non-human primate animal models of cancers. Zoological Research, 32(1): 70-80. DOI: 10.3724/SP.J.1141.2011.01070
Citation: XIA Hou-Jun, CHEN Ce-Shi. 2011: Progress of non-human primate animal models of cancers. Zoological Research, 32(1): 70-80. DOI: 10.3724/SP.J.1141.2011.01070

非人灵长类肿瘤模型研究进展(英文)

Progress of non-human primate animal models of cancers

  • 摘要: 癌症是人类第二大致死的疾病。将体外细胞模型获得的癌症研究结果向临床转化过程中, 动物活体实验是必不可少的一个环节。现在的肿瘤活体实验绝大部分采用啮齿类实验动物如小鼠和大鼠, 这是因为它们具有个体小、繁殖迅速、遗传背景清楚、转基因技术成熟等优势。但是啮齿类和人的亲缘关系比较远, 许多从啮齿类动物模型获得的研究结果不能在人体重现。非人灵长类动物在遗传进化、免疫、生理和代谢等诸多方面与人类高度近似, 理论上更加适合癌症研究。本文对现有的非人灵长类肿瘤研究做一综述, 主要集中介绍用化学和生物致癌剂在不同的非人灵长类动物诱导肿瘤的研究, 为将来用非人灵长类动物研究人类癌症奠定基础。

     

    Abstract: Cancer is the second leading disease causing human death. Pre-clinical in vivo studies are essential for translating in vitro laboratory research results into the clinic. Rodents, including the mouse and rat, have been widely used for pre-clinical studies due to their small size, clear genetic backgrounds, rapid propagation, and mature transgenic technologies. However, because rodents are evolutionarily distinct from humans, many pre-clinical research results using rodent models cannot be reproduced in the clinic. Non-human primates (NHPs) may be better animal models than rodents for human cancer research because NHPs and humans share greater similarity in regards to their genetic evolution, immune system, physiology and metabolism. This article reviews the latest progress of cancer research in NHPs by focusing on the carcinogenesis of different NHPs induced by chemical and biological carcinogens. Finally, future research directions for the use of NHPs in cancer research are discussed.

     

/

返回文章
返回