巴氯芬对慢性吗啡依赖后条件化位置偏好和戒断症状的抑制

Baclofen Inhibited the Morphine-induced Conditioned Placed Preference and Withdrawal Syndromes

摘要: 小鼠连续7天腹腔注射吗啡（40 mg/kg）建立条件化位置偏好模型，连续皮下递增注射吗啡（25、50、75、100、125、150 mg/kg），成瘾后腹腔注射纳络酮（6 mg/kg）诱导戒断症状（跳跃行为）建立戒断模型。腹腔注射GABAB受体激动剂巴氯芬（2 mg/kg）可以有效地抑制吗啡诱导的条件化位置偏好和减轻纳络酮诱导的戒断症状，结果表明GABA系统参与动物成瘾后渴求和戒断过程，激动GABAB受体可以在一定程度上抑制成瘾的心理和生理戒断症状。

Abstract: The mice with a continuous 7-day intraperitoneal injection of morphine was induced the conditioned placed reference (CPP) model and the mice with a continuous 7-day subcutaneous injection of morphine（25, 50, 75, 100, 125, 150 mg/kg）was induced withdrawal model (jump behavior) by naloxone administration(6 mg/kg). The results suggested that the administration of the GABA_B receptor agonist, baclofen, could effectively attenuate the expression of CPP and the nalxone-induced response in the mice. It could be concluded that activating GABA_B receptor can alleviate physical and psychic dependence syndromes to a certian extent .