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张明旭, 宋天章, 郑宏毅, 王雪卉, 路莹, 张瀚丹, 李婷, 庞伟, 郑永唐. 2019: 良好的肠道完整性及低微生物易位有助于SIVmac239感染的北平顶猴维持低. 动物学研究, 40(6): 522-531. DOI: 10.24272/j.issn.2095-8137.2019.047
引用本文: 张明旭, 宋天章, 郑宏毅, 王雪卉, 路莹, 张瀚丹, 李婷, 庞伟, 郑永唐. 2019: 良好的肠道完整性及低微生物易位有助于SIVmac239感染的北平顶猴维持低. 动物学研究, 40(6): 522-531. DOI: 10.24272/j.issn.2095-8137.2019.047
Ming-Xu Zhang, Tian-Zhang Song, Hong-Yi Zheng, Xue-Hui Wang, Ying Lu, Han-Dan Zhang, Ting Li, Wei Pang, Yong-Tang Zheng. 2019: Superior intestinal integrity and limited microbial translocation are associated with lower immune activation in SIVmac239-infected northern pig-tailed macaques (Macaca leonina). Zoological Research, 40(6): 522-531. DOI: 10.24272/j.issn.2095-8137.2019.047
Citation: Ming-Xu Zhang, Tian-Zhang Song, Hong-Yi Zheng, Xue-Hui Wang, Ying Lu, Han-Dan Zhang, Ting Li, Wei Pang, Yong-Tang Zheng. 2019: Superior intestinal integrity and limited microbial translocation are associated with lower immune activation in SIVmac239-infected northern pig-tailed macaques (Macaca leonina). Zoological Research, 40(6): 522-531. DOI: 10.24272/j.issn.2095-8137.2019.047

良好的肠道完整性及低微生物易位有助于SIVmac239感染的北平顶猴维持低

Superior intestinal integrity and limited microbial translocation are associated with lower immune activation in SIVmac239-infected northern pig-tailed macaques (Macaca leonina)

  • 摘要: 微生物易位导致HIV及SIV感染后系统性免疫活化是艾滋病发病的重要原因之一。我们发现在SIVmac239感染期间,北平顶猴CD8+ T细胞活化水平显著低于中国恒河猴。另外,其血浆脂多糖结合蛋白及可溶性CD14水平同样低于中国恒河猴。相较于中国恒河猴,北平顶猴的Chiu评分明显更低,这意味着其能维持更好的肠道完整性。无论在SIV感染或未感染的北平顶猴回肠和结肠上皮层均未发现明显的损伤,这一点不同于中国恒河猴。而且,在SIV感染或未感染的北平顶猴回肠和结肠部位均未检测到明显的微生物易位。以上研究结果表明,北平顶猴在SIV感染期间维持良好的肠道完整性及低水平的微生物易位可能是其CD8+ T细胞活化水平更低的重要原因。

     

    Abstract: Microbial translocation is a cause of systemic immune activation in HIV/SIV infection. In the present study, we found a lower CD8+ T cell activation level in Macaca leonina (northern pig-tailed macaques, NPMs) than in Macaca mulatta (Chinese rhesus macaques, ChRMs) during SIVmac239 infection. Furthermore, the levels of plasma LPS-binding protein and soluble CD14 in NPMs were lower than those in ChRMs. Compared with ChRMs, SIV-infected NPMs had lower Chiu scores, representing relatively normal intestinal mucosa. In addition, no obvious damage to the ileum or colon epithelial barrier was observed in either infected or uninfected NPMs, which differed to that found in ChRMs. Furthermore, no significant microbial translocation (Escherichia coli) was detected in the colon or ileum of infected or uninfected NPMs, which again differed to that observed in ChRMs. In conclusion, NPMs retained superior intestinal integrity and limited microbial translocation during SIV infection, which may contribute to their lower immune activation compared with ChRMs.

     

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