Volume 11 Issue 4
Jul.  1990
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HE Li-feng, XIAO Chang-hua, DONG Fu-ming, YANG Lian-xi. Studies on The Thrombin-Like Principles of Agkistrodon acutus Venom Ⅲ.Studies on Hemostatic Effect of Hemocoagulase. Zoological Research, 1990, 11(4): 331-335.
Citation: HE Li-feng, XIAO Chang-hua, DONG Fu-ming, YANG Lian-xi. Studies on The Thrombin-Like Principles of Agkistrodon acutus Venom Ⅲ.Studies on Hemostatic Effect of Hemocoagulase. Zoological Research, 1990, 11(4): 331-335.

Studies on The Thrombin-Like Principles of Agkistrodon acutus Venom Ⅲ.Studies on Hemostatic Effect of Hemocoagulase

  • Received Date: 1900-01-01
  • Rev Recd Date: 1900-01-01
  • Publish Date: 1990-11-22
  • Thrombin-like enzymes (TLE[3],TLE[4]) had been isolated and purified from the venom of Agkistrodon acutus.With 2-3 NIH units/kg in vivo the result showed that the blood coagulation time of rabbits was shortened in 1/3-1/2.In vivo eyperiments (2NIH or 3NIH/kg) after 1 hr TLE began to show effect,after 2-4 hr the effect was most strong,after 12 hr there was no effect.The properties of TLE is similar to hemocoagulase from venom Bathrope jararaca.The experiments showed that TLE 3 and 4 of A.acutus can used as hemostatic agents.
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Studies on The Thrombin-Like Principles of Agkistrodon acutus Venom Ⅲ.Studies on Hemostatic Effect of Hemocoagulase

Abstract: Thrombin-like enzymes (TLE[3],TLE[4]) had been isolated and purified from the venom of Agkistrodon acutus.With 2-3 NIH units/kg in vivo the result showed that the blood coagulation time of rabbits was shortened in 1/3-1/2.In vivo eyperiments (2NIH or 3NIH/kg) after 1 hr TLE began to show effect,after 2-4 hr the effect was most strong,after 12 hr there was no effect.The properties of TLE is similar to hemocoagulase from venom Bathrope jararaca.The experiments showed that TLE 3 and 4 of A.acutus can used as hemostatic agents.

HE Li-feng, XIAO Chang-hua, DONG Fu-ming, YANG Lian-xi. Studies on The Thrombin-Like Principles of Agkistrodon acutus Venom Ⅲ.Studies on Hemostatic Effect of Hemocoagulase. Zoological Research, 1990, 11(4): 331-335.
Citation: HE Li-feng, XIAO Chang-hua, DONG Fu-ming, YANG Lian-xi. Studies on The Thrombin-Like Principles of Agkistrodon acutus Venom Ⅲ.Studies on Hemostatic Effect of Hemocoagulase. Zoological Research, 1990, 11(4): 331-335.

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