Volume 33 Issue 1
Jan.  2012
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JI Fang, JIN Li-Sha, ZENG Xiao-Ming, ZHANG Xiu-Juan, ZHANG Yan-Chun, SUN Yun-Xiao, GAO Li-Hua, HE Hong, RAO Jun-Hua, LIU Xiao-Ming, PENG Bai-Lu. Comparison of gene expression between naturally occurring and diet-induced T2DM in cynomolgus monkeys. Zoological Research, 2012, 33(1): 79-84. doi: 10.3724/SP.J.1141.2012.01079
Citation: JI Fang, JIN Li-Sha, ZENG Xiao-Ming, ZHANG Xiu-Juan, ZHANG Yan-Chun, SUN Yun-Xiao, GAO Li-Hua, HE Hong, RAO Jun-Hua, LIU Xiao-Ming, PENG Bai-Lu. Comparison of gene expression between naturally occurring and diet-induced T2DM in cynomolgus monkeys. Zoological Research, 2012, 33(1): 79-84. doi: 10.3724/SP.J.1141.2012.01079

Comparison of gene expression between naturally occurring and diet-induced T2DM in cynomolgus monkeys

doi: 10.3724/SP.J.1141.2012.01079
  • Received Date: 2011-09-08
  • Rev Recd Date: 2011-12-22
  • Publish Date: 2012-02-22
  • To explore pathological alteration of T2DM in cynomolgus monkeys, gene expression profiles of peripheral blood leukocytes from spontaneous and diet-induced T2DM models was analyzed using quantitative real-time PCR. Among 36 T2DM associated genes tested, 19 genes (including G6PC, CCR2B, CTLA4) displayed a similar expression pattern in both spontaneous and diet-induced T2DM models and were significantly up-regulated or down-regulated compared to controls. Interestingly, expression abundance of all up-regulated genes in the diet-induced T2DM was stronger, although not significantly, than spontaneous models, indicating diet-induced T2DM in monkeys should be a reliable research model for changes in gene expression. The characteristic gene expression pattern obtained here may be useful for the clinical diagnosis of T2DM.
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Comparison of gene expression between naturally occurring and diet-induced T2DM in cynomolgus monkeys

doi: 10.3724/SP.J.1141.2012.01079

Abstract: To explore pathological alteration of T2DM in cynomolgus monkeys, gene expression profiles of peripheral blood leukocytes from spontaneous and diet-induced T2DM models was analyzed using quantitative real-time PCR. Among 36 T2DM associated genes tested, 19 genes (including G6PC, CCR2B, CTLA4) displayed a similar expression pattern in both spontaneous and diet-induced T2DM models and were significantly up-regulated or down-regulated compared to controls. Interestingly, expression abundance of all up-regulated genes in the diet-induced T2DM was stronger, although not significantly, than spontaneous models, indicating diet-induced T2DM in monkeys should be a reliable research model for changes in gene expression. The characteristic gene expression pattern obtained here may be useful for the clinical diagnosis of T2DM.

JI Fang, JIN Li-Sha, ZENG Xiao-Ming, ZHANG Xiu-Juan, ZHANG Yan-Chun, SUN Yun-Xiao, GAO Li-Hua, HE Hong, RAO Jun-Hua, LIU Xiao-Ming, PENG Bai-Lu. Comparison of gene expression between naturally occurring and diet-induced T2DM in cynomolgus monkeys. Zoological Research, 2012, 33(1): 79-84. doi: 10.3724/SP.J.1141.2012.01079
Citation: JI Fang, JIN Li-Sha, ZENG Xiao-Ming, ZHANG Xiu-Juan, ZHANG Yan-Chun, SUN Yun-Xiao, GAO Li-Hua, HE Hong, RAO Jun-Hua, LIU Xiao-Ming, PENG Bai-Lu. Comparison of gene expression between naturally occurring and diet-induced T2DM in cynomolgus monkeys. Zoological Research, 2012, 33(1): 79-84. doi: 10.3724/SP.J.1141.2012.01079
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