Volume 32 Issue 3
May  2011
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ZHANG Xiu-Juan, LI Xue-Jia, XIA Ji-Liang, YAN Sun-Xing, JI Fang, ZHANG Yan-Chun. Expression status of diabetes-associated genes in middle and aged cynomolgus monkeys. Zoological Research, 2011, 32(3): 300-306. doi: 10.3724/SP.J.1141.2011.03300
Citation: ZHANG Xiu-Juan, LI Xue-Jia, XIA Ji-Liang, YAN Sun-Xing, JI Fang, ZHANG Yan-Chun. Expression status of diabetes-associated genes in middle and aged cynomolgus monkeys. Zoological Research, 2011, 32(3): 300-306. doi: 10.3724/SP.J.1141.2011.03300

Expression status of diabetes-associated genes in middle and aged cynomolgus monkeys

doi: 10.3724/SP.J.1141.2011.03300
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  • Author Bio:

    ZHANG Xiu-Juan(1979-),E-mail: hallen6424@tom.com

  • Received Date: 2011-02-17
  • Rev Recd Date: 2011-04-19
  • Publish Date: 2011-06-22
  • A total of 138 middle and aged cynomolgus monkeys (Macaca fascicularis) (above 10 years) were classified into three groups based on fasting plasma glucose (FPG) values, specifically low FPG, normal FPG, and high FPG group. Total cholesterol (TCHO), triglycerides (TG), high density lipoprotein cholesterol (HDL-C), and low density lipoprotein cholesterol (LDL-C) were detected in blood by automatic biochemical analyzer. The mRNA expressions of 37 diabetes-associated genes were analyzed with Real-time PCRin monocytes isolated from monkey peripheral blood.No significant correlation between the four serum lipid indictors HDL-C, LDL-C, TCHO, TG and FPG (P>0.05) were found. However, the expressions of ACE, ACLY, PRKCB1, SLC2A4, SNAP23, VAPA, IGF2BP2, and IFNG were significantly enhanced when FPG increased (P<0.05).
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