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A depression model of social defeat etiology using tree shrews

WANG Jing ZHOU Qi-Xin LÜ Long-Bao XU Lin YANG Yue-Xiong

WANG Jing, ZHOU Qi-Xin, LÜ Long-Bao, XU Lin, YANG Yue-Xiong. A depression model of social defeat etiology using tree shrews. Zoological Research, 2012, 33(1): 92-98. doi: 10.3724/SP.J.1141.2012.01092
Citation: WANG Jing, ZHOU Qi-Xin, LÜ Long-Bao, XU Lin, YANG Yue-Xiong. A depression model of social defeat etiology using tree shrews. Zoological Research, 2012, 33(1): 92-98. doi: 10.3724/SP.J.1141.2012.01092

社会竞争失败病因学的抑郁症树鼩模型

doi: 10.3724/SP.J.1141.2012.01092
基金项目: 国家自然科学基金(81171294); 中科院知识创新工程重要方向项目(KSCX2-EW-R-12, KSCX2-EW-J-23)
详细信息
  • 中图分类号: Q175; Q133

A depression model of social defeat etiology using tree shrews

  • 摘要: 抑郁症是一种常见精神疾病, 主要表现为持续两周以上的情绪低落。世界卫生组织预测在2030 年抑郁症的疾病负担将高居所有疾病、伤残总负担的榜首。抑郁症面临三大难题:1)发病机理不完全清楚, 因而缺乏有效的预测预防途径和生物学诊断; 2)现有单胺类抗抑郁症药物起效慢, 也可能导致患者自杀风险增加; 3)缺乏副作用小的非单胺类快速起效抗抑郁症药物。针对这三大难题, 长期以来, 应用抑郁症啮齿类模型的众多研究并未取得实质性进展, 至少部分因素归咎于啮齿类与人类大脑功能的极大种属差异。树鼩是灵长类近亲, 具有更接近于人类的大脑功能。本文针对抑郁症发病机理假说、临床表象和抗抑郁症药物疗效等内容, 综述了社会竞争失败病因学的抑郁症树鼩模型可能会具有更好的疾病同源性、表象一致性和药物预见性。这一被长期忽视的抑郁症树鼩模型尽管还需要进一步完善, 但对其进一步深入研究可能为解决抑郁症的三大难题提供了一条新途径。
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A depression model of social defeat etiology using tree shrews

doi: 10.3724/SP.J.1141.2012.01092
    基金项目:  国家自然科学基金(81171294); 中科院知识创新工程重要方向项目(KSCX2-EW-R-12, KSCX2-EW-J-23)
  • 中图分类号: Q175; Q133

摘要: 抑郁症是一种常见精神疾病, 主要表现为持续两周以上的情绪低落。世界卫生组织预测在2030 年抑郁症的疾病负担将高居所有疾病、伤残总负担的榜首。抑郁症面临三大难题:1)发病机理不完全清楚, 因而缺乏有效的预测预防途径和生物学诊断; 2)现有单胺类抗抑郁症药物起效慢, 也可能导致患者自杀风险增加; 3)缺乏副作用小的非单胺类快速起效抗抑郁症药物。针对这三大难题, 长期以来, 应用抑郁症啮齿类模型的众多研究并未取得实质性进展, 至少部分因素归咎于啮齿类与人类大脑功能的极大种属差异。树鼩是灵长类近亲, 具有更接近于人类的大脑功能。本文针对抑郁症发病机理假说、临床表象和抗抑郁症药物疗效等内容, 综述了社会竞争失败病因学的抑郁症树鼩模型可能会具有更好的疾病同源性、表象一致性和药物预见性。这一被长期忽视的抑郁症树鼩模型尽管还需要进一步完善, 但对其进一步深入研究可能为解决抑郁症的三大难题提供了一条新途径。

English Abstract

王静, 周启心, 吕龙宝, 徐林, 杨跃雄. 社会竞争失败病因学的抑郁症树鼩模型[J]. 动物学研究, 2012, 33(1): 92-98. doi: 10.3724/SP.J.1141.2012.01092
引用本文: 王静, 周启心, 吕龙宝, 徐林, 杨跃雄. 社会竞争失败病因学的抑郁症树鼩模型[J]. 动物学研究, 2012, 33(1): 92-98. doi: 10.3724/SP.J.1141.2012.01092
WANG Jing, ZHOU Qi-Xin, LÜ Long-Bao, XU Lin, YANG Yue-Xiong. A depression model of social defeat etiology using tree shrews. Zoological Research, 2012, 33(1): 92-98. doi: 10.3724/SP.J.1141.2012.01092
Citation: WANG Jing, ZHOU Qi-Xin, LÜ Long-Bao, XU Lin, YANG Yue-Xiong. A depression model of social defeat etiology using tree shrews. Zoological Research, 2012, 33(1): 92-98. doi: 10.3724/SP.J.1141.2012.01092
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