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Qingbo Lu, Jianfei Sun, Quyang Yang, Wenwen Cai, Mengqin Xia, Fangfang Wu, Ning Gu, Zhijun Zhang. Brain magnetic stimulation using iron oxide nanoparticle-mediated selective treatment of the left prelimbic cortex as a novel strategy to rapidly improve depressive-like symptoms in mice[J]. Zoological Research. doi: 10.24272/j.issn.2095-8137.2020.076
Citation: Qingbo Lu, Jianfei Sun, Quyang Yang, Wenwen Cai, Mengqin Xia, Fangfang Wu, Ning Gu, Zhijun Zhang. Brain magnetic stimulation using iron oxide nanoparticle-mediated selective treatment of the left prelimbic cortex as a novel strategy to rapidly improve depressive-like symptoms in mice[J]. Zoological Research. doi: 10.24272/j.issn.2095-8137.2020.076

Brain magnetic stimulation using iron oxide nanoparticle-mediated selective treatment of the left prelimbic cortex as a novel strategy to rapidly improve depressive-like symptoms in mice

doi: 10.24272/j.issn.2095-8137.2020.076
Funds:  This work was supported by grants from the National Natural Science Foundation of China (81830040 to ZJ Zhang), the National Key Projects for Research and Development Program of China (2016YFC1306700 to ZJ Zhang, 2017YFA0104302 to N Gu and 2017YFA0104301 to JF Sun) and Program of Excellent Talents in Medical Science of Jiangsu Province (JCRCA2016006 to ZJ Zhang).
  • Received Date: 2020-04-25
  • Accepted Date: 2020-04-27
  • Available Online: 2020-05-13
  • Magnetic brain stimulation has contributed to the advancement of neuroscience. However, there remain challenges in the power of penetration and precision of magnetic stimulation, especially in small animals. Here, a novel strategy for magnetic brain stimulation in mice was established using a mild magnetic pulsed sequence and injection of superparamagnetic iron oxide (SPIO) nanodrugs to elevate local cortical susceptibility, namely a combined magnetic stimulation system (c-MSS). After imaging SPIO nanoparticles in the left prelimbic (PrL) cortex in mice, we were able to determine their safety and physical characteristics. Depressive-like behavior was established in mice using chronic unpredictable mild stress (CUMS) model. SPIO nanodrugs were delivered precisely to the left PrL cortex using in situ injection. A 0.1T magnetic field (adjustable frequency) was used for magnetic stimulation (5 min/session, two sessions daily). Biomarkers representing therapeutic effects were measured before and after c-MSS intervention. The c-MMS was found to rapidly improve depressive-like symptoms in CUMS mice after stimulation with a 10Hz field for 5 days, combined with increased brain-derived neurotrophic factor (BDNF) and inactivation of hypothalamic-pituitary-adrenal (HPA) axis function, which enhanced neuronal activity due to the SPIO nanoparticles mediated effect. c-MSS was shown to be safe and effective, representing a novel approach in the selective stimulation of arbitrary cortical targets in small animals, playing a bioelectric role in neural circuit regulation, including antidepressant effects for CUMS mice. This expands potential applications of magnetic stimulation and progresses brain research towards clinical application.
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    沈阳化工大学材料科学与工程学院 沈阳 110142

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Brain magnetic stimulation using iron oxide nanoparticle-mediated selective treatment of the left prelimbic cortex as a novel strategy to rapidly improve depressive-like symptoms in mice

doi: 10.24272/j.issn.2095-8137.2020.076
Funds:  This work was supported by grants from the National Natural Science Foundation of China (81830040 to ZJ Zhang), the National Key Projects for Research and Development Program of China (2016YFC1306700 to ZJ Zhang, 2017YFA0104302 to N Gu and 2017YFA0104301 to JF Sun) and Program of Excellent Talents in Medical Science of Jiangsu Province (JCRCA2016006 to ZJ Zhang).

Abstract: Magnetic brain stimulation has contributed to the advancement of neuroscience. However, there remain challenges in the power of penetration and precision of magnetic stimulation, especially in small animals. Here, a novel strategy for magnetic brain stimulation in mice was established using a mild magnetic pulsed sequence and injection of superparamagnetic iron oxide (SPIO) nanodrugs to elevate local cortical susceptibility, namely a combined magnetic stimulation system (c-MSS). After imaging SPIO nanoparticles in the left prelimbic (PrL) cortex in mice, we were able to determine their safety and physical characteristics. Depressive-like behavior was established in mice using chronic unpredictable mild stress (CUMS) model. SPIO nanodrugs were delivered precisely to the left PrL cortex using in situ injection. A 0.1T magnetic field (adjustable frequency) was used for magnetic stimulation (5 min/session, two sessions daily). Biomarkers representing therapeutic effects were measured before and after c-MSS intervention. The c-MMS was found to rapidly improve depressive-like symptoms in CUMS mice after stimulation with a 10Hz field for 5 days, combined with increased brain-derived neurotrophic factor (BDNF) and inactivation of hypothalamic-pituitary-adrenal (HPA) axis function, which enhanced neuronal activity due to the SPIO nanoparticles mediated effect. c-MSS was shown to be safe and effective, representing a novel approach in the selective stimulation of arbitrary cortical targets in small animals, playing a bioelectric role in neural circuit regulation, including antidepressant effects for CUMS mice. This expands potential applications of magnetic stimulation and progresses brain research towards clinical application.

Qingbo Lu, Jianfei Sun, Quyang Yang, Wenwen Cai, Mengqin Xia, Fangfang Wu, Ning Gu, Zhijun Zhang. Brain magnetic stimulation using iron oxide nanoparticle-mediated selective treatment of the left prelimbic cortex as a novel strategy to rapidly improve depressive-like symptoms in mice[J]. Zoological Research. doi: 10.24272/j.issn.2095-8137.2020.076
Citation: Qingbo Lu, Jianfei Sun, Quyang Yang, Wenwen Cai, Mengqin Xia, Fangfang Wu, Ning Gu, Zhijun Zhang. Brain magnetic stimulation using iron oxide nanoparticle-mediated selective treatment of the left prelimbic cortex as a novel strategy to rapidly improve depressive-like symptoms in mice[J]. Zoological Research. doi: 10.24272/j.issn.2095-8137.2020.076
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